Acidosis and impaired blood coagulation: What and how to correct before using recombinant human factor VIIa

Critical Care Medicine

Volumn 35, Issue 6, 2007, Pages 1627-1629

  Dempfle, Carl Erik ^a   Borggrefe, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acidosis; Eptacog alfa (activated); Factor VIIa; Fibrinogen; Platelets

Indexed keywords

BICARBONATE; BLOOD CLOTTING FACTOR; FIBRINOGEN; PLACEBO; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; TROMETAMOL;

ACIDOSIS; BLOOD CLOTTING DISORDER; BLOOD PH; CONCENTRATION (PARAMETERS); DISEASE SEVERITY; EDITORIAL; FIBRINOGEN BLOOD LEVEL; HEMODILUTION; INTENSIVE CARE; MICROCIRCULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SWINE; THROMBOCYTE COUNT;

ACIDOSIS; ANIMALS; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BUFFERS; FACTOR VIIA; FIBRINOGEN; HUMANS; HYDROGEN-ION CONCENTRATION; PLATELET COUNT; RECOMBINANT PROTEINS; SWINE; TROMETHAMINE;

EID: 34249318429     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000266827.47716.6C     Document Type: Editorial

References (19)

1. Cosgriff N, Moore EE, Sauaia A, et al: Predicting life-threatening coagulopathy in the massively transfused trauma patient: Hypothermia and acidoses revisited. J Trauma 1997; 42:857-861
2. Meng ZH, Wolberg AS, Monroe DM III, et al: The effect of temperature and pH on the activity of factor VIIa: Implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003; 55:886-891
3. Engstrom M, Schott U, Romner B, et al: Acidosis impairs the coagulation: A thromboelastographic study. J Trauma 2006; 61: 624-628
4. Engstrom M, Schott U, Nordstrom CH, et al: Increased lactate levels impair the coagulation system - A potential contributing factor to progressive hemorrhage after traumatic brain injury. J Neurosurg Anesthesiol 2006; 18:200-204
5. Martinowitz U, Kenet G, Segal E, et al: Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 2001; 51:431-438
6. Martinowitz U, Kenet G, Lubetski A, et al: Possible role of recombinant activated factor VII (rFVIIa) in the control of hemorrhage associated with massive trauma. Can J Anaesth 2002; 49:S15-S20
7. Boffard KD, Riou B, Warren B, et al: Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: Two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma 2005; 59:8-15
8. Rizoli SB, Nascimento B Jr, Osman F, et al: Recombinant activated coagulation factor VII and bleeding trauma patients. J Trauma 2006; 61:1419-1425
9. Martini WZ, Pusateri AE, Uscilowicz JM, et al: Independent contributions of hypothermia and acidosis to coagulopathy in swine. J Trauma 2005; 58:1002-1009
10. Martini W, Dubick MA, Wade CE, et al: Evaluation of tris- hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med 2007; 35:1568-1574
11. Martini WZ, Dubick MA, Pusateri AE, et al: Does bicarbonate correct coagulation function impaired by acidosis in swine? J Trauma 2006; 61:99-106
12. Martini WZ, Chinkes DL, Sondeen J, et al: Effects of hemorrhage and lactated Ringer's resuscitation on coagulation and fibrinogen metabolism in swine. Shock 2006; 26: 396-401
13. Wiman B, Mellbring G, Ranby M: Plasminogen activator release during venous stasis and exercise as determined by a new specific assay. Clin Chim Acta 1983; 127: 279 -288
14. Wiman B, Chmielewska J, Ranby M: Inactivation of tissue plasminogen activator in plasma: Demonstration of a complex with a new rapid inhibitor. J Biol Chem 1984; 259: 3644-3647
15. Wiman B, Ranby M: Determination of soluble fibrin in plasma by a rapid and quantitative spectrophotometric assay. Thromb Haemost 1986; 55:189-193
16. Ranby M: Studies on the kinetics of plasminogen activation by tissue plasminogen activator. Biochim Biophys Acta 1982; 704: 461-469
17. Holm B, Nilsen DW, Kierulf P, et al: Purification and characterization of 3 fibrinogens with different molecular weights obtained from normal human plasma. Thromb Res 1985; 37:165-176
18. Dempfle CE, Pfitzner SA, Schott D, et al: Fibrinogen heterogeneity in homozygous plasminogen deficiency type I: further evidence that plasmin is not involved in formation of LMW- and LMW′-fibrinogen. Thromb Haemost 1997; 77:879-883
19. Attar S, Boyd D, Layne E, et al: Alterations in coagulation and fibrinolytic mechanisms in acute trauma. J Trauma 1969; 9:939-965