메뉴 건너뛰기




Volumn 2, Issue 2, 2007, Pages 111-119

HIV management: New approaches

Author keywords

HIV management; Non nucleoside reverse transcriptase inhibitors (NNRTIs); Nucleoside reverse transcriptase inhibitors (NRTIs); Protease; Protease inhibitors (PIs); Reverse transcriptase

Indexed keywords

2' DEOXY 3' OXA 4' THIOCYTIDINE; 3' FLUOROTHYMIDINE; ABACAVIR; AMDOXOVIR; AVX 754; BETA DEXTRO 2,6 GUANOSINE; CALANOLIDE A; CP 94707; DAPIVIRINE; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; ELVUCITABINE; EMTRICITABINE; ENVELOPE PROTEIN; ETRAVIRINE; GAG PROTEIN; LAMIVUDINE; NEVIRAPINE; POL PROTEIN; PROTEINASE; PROTEINASE INHIBITOR; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 34249317631     PISSN: 15748855     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488507780619031     Document Type: Review
Times cited : (3)

References (88)
  • 1
    • 0020532060 scopus 로고
    • Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)
    • Gallo RC, Sarin PS, Gelmann EP, et al. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 1983; 220: 865-7.
    • (1983) Science , vol.220 , pp. 865-867
    • Gallo, R.C.1    Sarin, P.S.2    Gelmann, E.P.3
  • 2
    • 0020596551 scopus 로고
    • Isolation of a Tlymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • Barre-Sinoussi F, Chermann JC, Rey F, et al. Isolation of a Tlymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 1983; 220: 868-71.
    • (1983) Science , vol.220 , pp. 868-871
    • Barre-Sinoussi, F.1    Chermann, J.C.2    Rey, F.3
  • 3
    • 34249337252 scopus 로고    scopus 로고
    • source www.UNAIDS.org et al.
    • source www.UNAIDS.org et al.
  • 4
    • 0023052240 scopus 로고
    • Isolation of a new human retrovirus from West African patients with AIDS
    • Clavel F, Guetard D, Brun-Vezinet F, et al. Isolation of a new human retrovirus from West African patients with AIDS. Science 1986; 233: 343-6.
    • (1986) Science , vol.233 , pp. 343-346
    • Clavel, F.1    Guetard, D.2    Brun-Vezinet, F.3
  • 5
    • 0034625771 scopus 로고    scopus 로고
    • Timing the ancestor of the HIV-1 pandemic strains
    • Korber B, Muldoon M, Theiler J, et al. Timing the ancestor of the HIV-1 pandemic strains. Science 2000; 288: 1789-96.
    • (2000) Science , vol.288 , pp. 1789-1796
    • Korber, B.1    Muldoon, M.2    Theiler, J.3
  • 7
    • 34249331832 scopus 로고    scopus 로고
    • Nelson, Michael M Cox
    • fourth Edition, New York, Freeman WH and Company
    • David L, Nelson, Michael M Cox. Principles of Biochemistry, fourth Edition, New York, Freeman WH and Company. 2005; 1022-4.
    • (2005) Principles of Biochemistry , pp. 1022-1024
    • David, L.1
  • 8
    • 0032506207 scopus 로고    scopus 로고
    • HIV-1 gag proteins: Diverse functions in the virus life cycle
    • Freed EO. HIV-1 gag proteins: diverse functions in the virus life cycle. Virology 1998; 251: 1-15.
    • (1998) Virology , vol.251 , pp. 1-15
    • Freed, E.O.1
  • 11
    • 0001707601 scopus 로고
    • 3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T59 lymphotropic virus type III/ Lymphadenopathy -associated virus in vitro
    • Mitsuya H, Weinhold KJ, Furman PA, et al. 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T59 lymphotropic virus type III/ Lymphadenopathy -associated virus in vitro. Proc Natl Acad Sci USA 1985; 82: 7096-100.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3
  • 12
    • 1442355578 scopus 로고    scopus 로고
    • HIV drug resistance
    • Clavel F, Hance AJ. HIV drug resistance. N Engl J Med 2004; 350: 1023-35.
    • (2004) N Engl J Med , vol.350 , pp. 1023-1035
    • Clavel, F.1    Hance, A.J.2
  • 13
    • 0036696712 scopus 로고    scopus 로고
    • Targeting HIV: Antiretroviral therapy and development of drug resistance
    • Menéndez-Arias L. Targeting HIV: antiretroviral therapy and development of drug resistance. Trends Pharmacol Sci 2002; 23: 381-88.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 381-388
    • Menéndez-Arias, L.1
  • 14
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
    • Larder BA, Darby G, Richman DD. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 1989; 243: 1731-4.
    • (1989) Science , vol.243 , pp. 1731-1734
    • Larder, B.A.1    Darby, G.2    Richman, D.D.3
  • 15
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996; 271: 1582-6.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3
  • 16
    • 3242877615 scopus 로고    scopus 로고
    • Resistance to HIV protease inhibitors: Mechanisms and clinical consequences
    • De Mendoza C, Soriano V. Resistance to HIV protease inhibitors: mechanisms and clinical consequences. Curr Drug Metab 2004; 5: 321-8.
    • (2004) Curr Drug Metab , vol.5 , pp. 321-328
    • De Mendoza, C.1    Soriano, V.2
  • 17
    • 34249305990 scopus 로고    scopus 로고
    • http:/www.iasusa.org/resistance_mutations/index.html.
  • 18
    • 0034639473 scopus 로고    scopus 로고
    • Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy
    • Descamps D, Flandre P, Calvez V. et al. Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. JAMA 2000; 283: 205-11.
    • (2000) JAMA , vol.283 , pp. 205-211
    • Descamps, D.1    Flandre, P.2    Calvez, V.3
  • 19
    • 0034639490 scopus 로고    scopus 로고
    • Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens
    • Havlir DV, Hellmann NS, Petropoulos CJ, et al. Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens. JAMA 2000; 283: 229-34.
    • (2000) JAMA , vol.283 , pp. 229-234
    • Havlir, D.V.1    Hellmann, N.S.2    Petropoulos, C.J.3
  • 20
    • 0033946694 scopus 로고    scopus 로고
    • Absence of zidovudine resistance in antiretroviral-naïve patients following Zidovudine/ Lamivudine/protease inhibitor combination therapy: Virological evaluation of the AVANTI 2 and AVANTI 3 studies
    • Maguire M, Gartland M, Moore S, et al. Absence of zidovudine resistance in antiretroviral-naïve patients following Zidovudine/ Lamivudine/protease inhibitor combination therapy: virological evaluation of the AVANTI 2 and AVANTI 3 studies. AIDS 2000; 14: 1195-201.
    • (2000) AIDS , vol.14 , pp. 1195-1201
    • Maguire, M.1    Gartland, M.2    Moore, S.3
  • 21
    • 0035964694 scopus 로고    scopus 로고
    • Changes in the rate of geno-typic resistance to antiretroviral drugs in Spain
    • Gallego O, Ruiz L, Vallejo A, et al. Changes in the rate of geno-typic resistance to antiretroviral drugs in Spain. AIDS 2001; 15: 1894-96.
    • (2001) AIDS , vol.15 , pp. 1894-1896
    • Gallego, O.1    Ruiz, L.2    Vallejo, A.3
  • 22
    • 0037182766 scopus 로고    scopus 로고
    • Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
    • Walmsley S, Bernstein B, King M, et al. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med 2002; 346: 2039-46.
    • (2002) N Engl J Med , vol.346 , pp. 2039-2046
    • Walmsley, S.1    Bernstein, B.2    King, M.3
  • 23
    • 0038234808 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type I: 2003 recommendations of the International AIDS Society-USA panel
    • Hirsch MS, Brun-Vezinet F, Clotet B, et al. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type I: 2003 recommendations of the International AIDS Society-USA panel. Clin Infect Dis 2003; 37: 113-28.
    • (2003) Clin Infect Dis , vol.37 , pp. 113-128
    • Hirsch, M.S.1    Brun-Vezinet, F.2    Clotet, B.3
  • 24
    • 33646681785 scopus 로고    scopus 로고
    • Clinical validation of atazanavir/ritonavir genotypic resistance score in PI-experienced patients
    • Vora S, Marcelin AG, Gunthard H, et al. Clinical validation of atazanavir/ritonavir genotypic resistance score in PI-experienced patients. Antivir Ther 2005; 10: S9.
    • (2005) Antivir Ther , vol.10
    • Vora, S.1    Marcelin, A.G.2    Gunthard, H.3
  • 25
    • 14744283486 scopus 로고    scopus 로고
    • Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: Mutation patterns and baseline correlates
    • Mo H, King MS, King K, Molla A, Brun S, Kempf DJ. Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates. J Virol 2005; 79: 3329-38.
    • (2005) J Virol , vol.79 , pp. 3329-3338
    • Mo, H.1    King, M.S.2    King, K.3    Molla, A.4    Brun, S.5    Kempf, D.J.6
  • 26
    • 4744349522 scopus 로고    scopus 로고
    • Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen
    • Friend J, Parkin N, Liegler T, Martin JN, Deeks SG. Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen. AIDS 2004; 18: 1965-66.
    • (2004) AIDS , vol.18 , pp. 1965-1966
    • Friend, J.1    Parkin, N.2    Liegler, T.3    Martin, J.N.4    Deeks, S.G.5
  • 27
    • 22244462118 scopus 로고    scopus 로고
    • Structural analysis of an HIV-1 protease 147A mutant resistant to the protease inhibitor lopinavir
    • Kagan RM, Shenderovich MD, Heseltine PN, Ramnarayan K. Structural analysis of an HIV-1 protease 147A mutant resistant to the protease inhibitor lopinavir. Protein Sci 2005; 14: 1870-8.
    • (2005) Protein Sci , vol.14 , pp. 1870-1878
    • Kagan, R.M.1    Shenderovich, M.D.2    Heseltine, P.N.3    Ramnarayan, K.4
  • 28
    • 34249294189 scopus 로고    scopus 로고
    • Boehringer Ingelheim. Aptivus [package insert, Germany: Boehringer Ingelheim. 2005
    • Boehringer Ingelheim. Aptivus [package insert]. Germany: Boehringer Ingelheim. 2005.
  • 29
    • 33745910317 scopus 로고    scopus 로고
    • Impact of Mutations in HR2 of HIV-1 env gp41 on susceptibility to enfuvirtide
    • Stanfield-Oakley SA, Mosier SM, Davison DK, et al. Impact of Mutations in HR2 of HIV-1 env gp41 on susceptibility to enfuvirtide. Antivir Ther 2005; 10: S75.
    • (2005) Antivir Ther , vol.10
    • Stanfield-Oakley, S.A.1    Mosier, S.M.2    Davison, D.K.3
  • 30
    • 0034685037 scopus 로고    scopus 로고
    • Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society-USA panel
    • Carpenter CC, Cooper DA, Fischl MA, et al. Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA panel. JAMA 2000; 283: 381-90.
    • (2000) JAMA , vol.283 , pp. 381-390
    • Carpenter, C.C.1    Cooper, D.A.2    Fischl, M.A.3
  • 31
    • 0033933688 scopus 로고    scopus 로고
    • A randomised, open-label comparison of three highly active antiretroviral therapy regimens including two nucleoside analogues and indinavir for previously untreated HIV-1 infection: The OzCombo 1 study
    • Carr A, Chuah J, Hudson J, et al. A randomised, open-label comparison of three highly active antiretroviral therapy regimens including two nucleoside analogues and indinavir for previously untreated HIV-1 infection: the OzCombo 1 study. AIDS 2000; 14: 1171-80.
    • (2000) AIDS , vol.14 , pp. 1171-1180
    • Carr, A.1    Chuah, J.2    Hudson, J.3
  • 33
    • 0030028805 scopus 로고    scopus 로고
    • Effects of 39-deoxynucleotide 59- triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type-1 reverse transcription of minus- strand strong-stop DNA
    • Arts EJ, Marois JP, Gu Z, Le Grice SFJ, Wainberg MA. Effects of 39-deoxynucleotide 59- triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type-1 reverse transcription of minus- strand strong-stop DNA. J Virol 1996; 70: 712-20.
    • (1996) J Virol , vol.70 , pp. 712-720
    • Arts, E.J.1    Marois, J.P.2    Gu, Z.3    Le Grice, S.F.J.4    Wainberg, M.A.5
  • 34
    • 0026465275 scopus 로고
    • Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 29,39-dideoxyinosine and 29,39-dideoxycytidine
    • Gu Z, Gao Q, Li X, Parniak MA, Wainberg MA. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 29,39-dideoxyinosine and 29,39-dideoxycytidine. J Virol 1992; 66: 7128-35.
    • (1992) J Virol , vol.66 , pp. 7128-7135
    • Gu, Z.1    Gao, Q.2    Li, X.3    Parniak, M.A.4    Wainberg, M.A.5
  • 35
    • 0035794282 scopus 로고    scopus 로고
    • Anti-HIV type 1 activity of 3′-fluoro-3′-deoxythymidine for several different multidrug-resistant mutants
    • Kim EY, Vrang L, Oberg B, Merigan TC. Anti-HIV type 1 activity of 3′-fluoro-3′-deoxythymidine for several different multidrug-resistant mutants. AIDS Res Hum Retroviruses 2001; 17: 401-407.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 401-407
    • Kim, E.Y.1    Vrang, L.2    Oberg, B.3    Merigan, T.C.4
  • 36
    • 0026509422 scopus 로고
    • Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 39-fluoro-39-deoxythymidine
    • Kong XB, Zhu QY, Vidal PM, et al. Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 39-fluoro-39-deoxythymidine. Antimicrob Agents Chemother 1992; 36: 808-18.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 808-818
    • Kong, X.B.1    Zhu, Q.Y.2    Vidal, P.M.3
  • 37
    • 0026992106 scopus 로고
    • Three-drug synergistic inhibition of HIV-1 replication in vitro by 39-fluoro-39- deoxythymidine, recombinant soluble CD4 and recombinant interferon-alpha
    • Pan XZ, Qui ZD, Baron PA, et al. Three-drug synergistic inhibition of HIV-1 replication in vitro by 39-fluoro-39- deoxythymidine, recombinant soluble CD4 and recombinant interferon-alpha. AIDS Res Hum Retroviruses 1992; 8: 589-95.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 589-595
    • Pan, X.Z.1    Qui, Z.D.2    Baron, P.A.3
  • 38
    • 0025860146 scopus 로고
    • Antiviral effects of 39 fluorothymidine and 39-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus
    • Lundgren B, Bottiger D, Ljungdahl-Stahle E, et al. Antiviral effects of 39 fluorothymidine and 39-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus. J AIDS 1991; 4: 489-98.
    • (1991) J AIDS , vol.4 , pp. 489-498
    • Lundgren, B.1    Bottiger, D.2    Ljungdahl-Stahle, E.3
  • 39
    • 4243240145 scopus 로고
    • Phase I phamacokinetic evaluation of 39-deoxy-39-fluorothymidine (FLT), a new potent anti HIV nucleoside
    • abstract 2114, Florence, Italy. Rome
    • Barditch-Crovo PA, Kornhauser DM, Petty BG, et al. Phase I phamacokinetic evaluation of 39-deoxy-39-fluorothymidine (FLT), a new potent anti HIV nucleoside [abstract 2114]. VIIth International Conference on AIDS Florence, Italy. Rome 1991; 210.
    • (1991) VIIth International Conference on AIDS , pp. 210
    • Barditch-Crovo, P.A.1    Kornhauser, D.M.2    Petty, B.G.3
  • 40
    • 3042693911 scopus 로고    scopus 로고
    • MIV-310 reduces HIV viral load in patients failing multiple antiretroviral therapy: Results from a 4-week phase II study
    • Katlama C, Ghosn J, Tubiana R, et al. MIV-310 reduces HIV viral load in patients failing multiple antiretroviral therapy: results from a 4-week phase II study. AIDS 2004; 18: 1299-304.
    • (2004) AIDS , vol.18 , pp. 1299-1304
    • Katlama, C.1    Ghosn, J.2    Tubiana, R.3
  • 41
    • 0036232997 scopus 로고    scopus 로고
    • DPC-817: A cytidine nucleoside analog with activity against zidovudineand lamivudine-resistant viral variants
    • Schinazi RF, Mellors JW, Bazmi HZ, et al. DPC-817: a cytidine nucleoside analog with activity against zidovudineand lamivudine-resistant viral variants. Antimicrob Agents Chemother 2002; 46: 1394-401.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1394-1401
    • Schinazi, R.F.1    Mellors, J.W.2    Bazmi, H.Z.3
  • 42
    • 4344566602 scopus 로고    scopus 로고
    • Potent antiviral effect of Reverset™ in HIV-1 infected adults following a single oral dose
    • Stuyver LJ, McBrayer TR, Schürmann D, et al. Potent antiviral effect of Reverset™ in HIV-1 infected adults following a single oral dose. Antivir Ther 2004; 9: 529-36.
    • (2004) Antivir Ther , vol.9 , pp. 529-536
    • Stuyver, L.J.1    McBrayer, T.R.2    Schürmann, D.3
  • 43
    • 0033029686 scopus 로고    scopus 로고
    • Pharmacokinetics of the anti-viral agent -D-2,3- didehydro-2,3-dideoxy-5- fluorocytidine in rhesus monkeys
    • Ma L, Hurwitz SJ, McAtee JJ, et al. Pharmacokinetics of the anti-viral agent -D-2,3- didehydro-2,3-dideoxy-5- fluorocytidine in rhesus monkeys. Antimicrob Agents Chemother 43: 381-4.
    • Antimicrob Agents Chemother , vol.43 , pp. 381-384
    • Ma, L.1    Hurwitz, S.J.2    McAtee, J.J.3
  • 44
    • 0028889357 scopus 로고
    • Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates
    • Blaney SM, Daniel MJ, Harker AJ, Godwin K, Balis FM. Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates. Antimicrob Agents Chemother 1995; 39: 2779-82.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2779-2782
    • Blaney, S.M.1    Daniel, M.J.2    Harker, A.J.3    Godwin, K.4    Balis, F.M.5
  • 45
    • 0025888963 scopus 로고
    • Pharmacokinetic evaluation of drug interactions with zidovudine: Probenecid and zidovudine in monkeys
    • Qian M, Finco TS, Metha M, Viswanathan CT, Gallo J. Pharmacokinetic evaluation of drug interactions with zidovudine: probenecid and zidovudine in monkeys. J Pharm Sci 1991; 80: 1007-11.
    • (1991) J Pharm Sci , vol.80 , pp. 1007-1011
    • Qian, M.1    Finco, T.S.2    Metha, M.3    Viswanathan, C.T.4    Gallo, J.5
  • 46
    • 0034090290 scopus 로고    scopus 로고
    • Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2′-deoxy-3′-oxa4′-thio-5-fluorocytidine
    • Richard N, Salomon H, Rando R, et al. Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2′-deoxy-3′-oxa4′-thio-5-fluorocytidine. Antimicrob Agents Chemother 2000; 44: 1127-31.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1127-1131
    • Richard, N.1    Salomon, H.2    Rando, R.3
  • 47
    • 0032819048 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa4′-thiacytidine
    • De Muys J-M, Gourdeau H, Nguyen-Ba N, et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa4′-thiacytidine. Antimicrob Agents Chemother 1999; 43: 1835-44.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1835-1844
    • De Muys, J.-M.1    Gourdeau, H.2    Nguyen-Ba, N.3
  • 48
    • 17344362757 scopus 로고    scopus 로고
    • Elvucitabine: Potent antiviral activity demonstrated in multi-drug resistant HIV infection
    • Dunkle LM, Gathe JC, Pedevillano DE, et al. Elvucitabine: potent antiviral activity demonstrated in multi-drug resistant HIV infection. Antivir Ther 2003; 8: S5.
    • (2003) Antivir Ther , vol.8
    • Dunkle, L.M.1    Gathe, J.C.2    Pedevillano, D.E.3
  • 49
    • 11244255158 scopus 로고    scopus 로고
    • Pharmacological evaluation of a dual deoxycytidine analogue combination: 3TC and SPD754
    • Abstract A-508, San Francisco, USA
    • Bethell R, Adams J, De Muys J, et al. Pharmacological evaluation of a dual deoxycytidine analogue combination: 3TC and SPD754 [Abstract A-508] 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA 2004.
    • (2004) 11th Conference on Retroviruses and Opportunistic Infections
    • Bethell, R.1    Adams, J.2    De Muys, J.3
  • 50
    • 0035162759 scopus 로고    scopus 로고
    • Mechanism of action of 1-ß-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-ß-D-dioxolane guanosine
    • Furman PA, Jeffrey J, Kiefer LL, et al. Mechanism of action of 1-ß-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-ß-D-dioxolane guanosine. Antimicrob Agents Chemother 2001; 45: 158-65.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 158-165
    • Furman, P.A.1    Jeffrey, J.2    Kiefer, L.L.3
  • 51
    • 0033921632 scopus 로고    scopus 로고
    • In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)ß-D-dioxolane-guanosine and suppress resistance to 3′-azido- 3′-deoxythymidine
    • Bazmi HZ, Hammond JL, Cavalcanti SC, et al. In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)ß-D-dioxolane-guanosine and suppress resistance to 3′-azido- 3′-deoxythymidine. Antimicrob Agents Chemother 2000; 44: 1783-8.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1783-1788
    • Bazmi, H.Z.1    Hammond, J.L.2    Cavalcanti, S.C.3
  • 52
    • 0036156325 scopus 로고    scopus 로고
    • Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients from whom standard nucleoside therapy fails
    • Mewshaw JP, Myrick FT, Wakefield DACS, et al. Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients from whom standard nucleoside therapy fails. J Acquir Immune Defic Syndr 2002; 29: 11-20.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 11-20
    • Mewshaw, J.P.1    Myrick, F.T.2    Wakefield, D.A.C.S.3
  • 53
    • 0032533207 scopus 로고    scopus 로고
    • A 6-basepair insert in the reverse transcriptase gene of human immuno deficiency virus type 1 confers resistance to multiple nucleoside inhibitors
    • Winters MA, Coolley KL, Girard YA, et al. A 6-basepair insert in the reverse transcriptase gene of human immuno deficiency virus type 1 confers resistance to multiple nucleoside inhibitors. J Clin Invest 1998; 102: 1769-75.
    • (1998) J Clin Invest , vol.102 , pp. 1769-1775
    • Winters, M.A.1    Coolley, K.L.2    Girard, Y.A.3
  • 54
    • 0038143190 scopus 로고    scopus 로고
    • Dioxolane guanosine 5′-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase - steady state and pre-steady state kinetic analyses
    • Jeffrey JL, Feng JY, Qi CCR, Anderson KS, Furman PA. Dioxolane guanosine 5′-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase - steady state and pre-steady state kinetic analyses. J Biol Chem 2003; 278: 18971-9.
    • (2003) J Biol Chem , vol.278 , pp. 18971-18979
    • Jeffrey, J.L.1    Feng, J.Y.2    Qi, C.C.R.3    Anderson, K.S.4    Furman, P.A.5
  • 55
    • 34249288097 scopus 로고    scopus 로고
    • Effects of M184V mutation in multi- dideoxynucleoside analog resistant HTV-1 reverse transcriptase on removal of ß-D-dioxolane- guanine monophosphate from blocked primer
    • Lennerstrand J, Hassani Espili N, Pavlova A, et al. Effects of M184V mutation in multi- dideoxynucleoside analog resistant HTV-1 reverse transcriptase on removal of ß-D-dioxolane- guanine monophosphate from blocked primer. Antivir Ther 2005; 10: S79.
    • (2005) Antivir Ther , vol.10
    • Lennerstrand, J.1    Hassani Espili, N.2    Pavlova, A.3
  • 56
    • 33747788350 scopus 로고    scopus 로고
    • 1-(ß-D-Dioxolane)thymidine (DOT) is a TK-dependent orally bioavailable nucleoside with specific activity against HIV-1 resistant variants
    • Schinazi RF, Asif G, Detorio M, et al. 1-(ß-D-Dioxolane)thymidine (DOT) is a TK-dependent orally bioavailable nucleoside with specific activity against HIV-1 resistant variants. Antivir Ther 2005; 10: S65.
    • (2005) Antivir Ther , vol.10
    • Schinazi, R.F.1    Asif, G.2    Detorio, M.3
  • 57
    • 0036840520 scopus 로고    scopus 로고
    • Stampidine is a potent inhibitor of zidovudine and nucleoside analog reverse transcriptase inhibitor resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations
    • Uckun FM, Pendergrass S, Venkatachalam TK, Qazi S, Richman DD. Stampidine is a potent inhibitor of zidovudine and nucleoside analog reverse transcriptase inhibitor resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations. Antimicrob Agents Chemother 2002; 46: 3613-6.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3613-3616
    • Uckun, F.M.1    Pendergrass, S.2    Venkatachalam, T.K.3    Qazi, S.4    Richman, D.D.5
  • 58
    • 0034744423 scopus 로고    scopus 로고
    • 4′-Ethynyl nucleoside analogs: Potent inhibitors of multi drug-resistant human immunodeficiency virus variants in vitro
    • Kodama EI, Kohgo S, Kitano K, et al. 4′-Ethynyl nucleoside analogs: potent inhibitors of multi drug-resistant human immunodeficiency virus variants in vitro. Antimicrob Agents Chemother 2001; 45: 1539-46.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1539-1546
    • Kodama, E.I.1    Kohgo, S.2    Kitano, K.3
  • 59
    • 0036829992 scopus 로고    scopus 로고
    • The molecular mechanism of multidrug resistance by the Q151M human immuno deficiency virus type 1 reverse transcriptase and its suppression using á-boranophosphate nucleotide analogues
    • Deval J, Selmi B, Boretto J, et al. The molecular mechanism of multidrug resistance by the Q151M human immuno deficiency virus type 1 reverse transcriptase and its suppression using á-boranophosphate nucleotide analogues. J Biol Chem 2002; 277: 42097-104.
    • (2002) J Biol Chem , vol.277 , pp. 42097-42104
    • Deval, J.1    Selmi, B.2    Boretto, J.3
  • 60
    • 19444382473 scopus 로고    scopus 로고
    • Suppression of multi-drug-resistant HIV-1 reverse transcriptase primer unblocking activity by α-phosphate- modified thymidine analogues
    • Matamoros T, Deval J, Guerreiro C, Mulard L, Canard B, Menéndez-Arias L. Suppression of multi-drug-resistant HIV-1 reverse transcriptase primer unblocking activity by α-phosphate- modified thymidine analogues. J Mol Biol 2005; 349: 451-63.
    • (2005) J Mol Biol , vol.349 , pp. 451-463
    • Matamoros, T.1    Deval, J.2    Guerreiro, C.3    Mulard, L.4    Canard, B.5    Menéndez-Arias, L.6
  • 61
    • 9744258219 scopus 로고    scopus 로고
    • Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
    • Das K, Lewi PJ, Hughes SH, Arnold E. Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors. Prog Biophys Mol Biol 2005; 88: 209-31.
    • (2005) Prog Biophys Mol Biol , vol.88 , pp. 209-231
    • Das, K.1    Lewi, P.J.2    Hughes, S.H.3    Arnold, E.4
  • 62
    • 4544265135 scopus 로고    scopus 로고
    • Conformational changes in HIV-1 reverse transcriptase induced by nonnucleosides reverse transcriptase inhibitor binding
    • Sluis-Cremer N, Temiz NA, Bahar I. Conformational changes in HIV-1 reverse transcriptase induced by nonnucleosides reverse transcriptase inhibitor binding. Curr HIV Res 2004; 2: 323-32.
    • (2004) Curr HIV Res , vol.2 , pp. 323-332
    • Sluis-Cremer, N.1    Temiz, N.A.2    Bahar, I.3
  • 63
  • 64
    • 15444380338 scopus 로고    scopus 로고
    • De Corte BL. From 4,5,6,7-tetrahydro-5-methylimidazol [4,5,1 jk] (1,4) benzodiazepine -2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Med Chem 2005; 48: 1689-96.
    • De Corte BL. From 4,5,6,7-tetrahydro-5-methylimidazol [4,5,1 jk] (1,4) benzodiazepine -2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Med Chem 2005; 48: 1689-96.
  • 65
    • 0036782103 scopus 로고    scopus 로고
    • Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase
    • Temiz NA, Bahar I. Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase. Proteins 2002; 49: 61-70.
    • (2002) Proteins , vol.49 , pp. 61-70
    • Temiz, N.A.1    Bahar, I.2
  • 66
    • 0037613579 scopus 로고    scopus 로고
    • Validation of a model for the complex of HIV-1 reverse transcriptase with nonnucleoside inhibitor TMC125
    • Udier-Blagovic M, Tirado-Rives J, Jorgensen WL. Validation of a model for the complex of HIV-1 reverse transcriptase with nonnucleoside inhibitor TMC125. J Am Chem Soc 2003; 125: 6016-7.
    • (2003) J Am Chem Soc , vol.125 , pp. 6016-6017
    • Udier-Blagovic, M.1    Tirado-Rives, J.2    Jorgensen, W.L.3
  • 67
    • 9644291579 scopus 로고    scopus 로고
    • TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1
    • Andries K, Azijn H, Thielemans T, et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother 2004; 48: 4680-6.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4680-4686
    • Andries, K.1    Azijn, H.2    Thielemans, T.3
  • 68
    • 12144287763 scopus 로고    scopus 로고
    • An open-label assessment of TMC125: A new, next -generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
    • Gazzard BG, Pozniak AL, Rosenbaum W, et al. An open-label assessment of TMC125: a new, next -generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance. AIDS 2003; 17: 49-54.
    • (2003) AIDS , vol.17 , pp. 49-54
    • Gazzard, B.G.1    Pozniak, A.L.2    Rosenbaum, W.3
  • 69
    • 20144372481 scopus 로고    scopus 로고
    • In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile <278474, Rilpivirine)
    • Janssen PAJ, Lewi PJ, Arnold E, et al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile <278474, Rilpivirine). J Med Chem 2005; 48:1901-9.
    • (2005) J Med Chem , vol.48 , pp. 1901-1909
    • Janssen, P.A.J.1    Lewi, P.J.2    Arnold, E.3
  • 70
    • 3242657912 scopus 로고    scopus 로고
    • Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
    • Pata JD, Stirtan WG, Goldstein SW, Steitz TA. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proc Natl Acad Sci USA 2004; 101: 10548-53.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10548-10553
    • Pata, J.D.1    Stirtan, W.G.2    Goldstein, S.W.3    Steitz, T.A.4
  • 71
    • 1842756473 scopus 로고    scopus 로고
    • Total Synthesis of (±)-Inophyllum B
    • Gao Q, Wang L, Liang TX. Total Synthesis of (±)-Inophyllum B. Chin Chem Lett 2002; 13(8): 714-6.
    • (2002) Chin Chem Lett , vol.13 , Issue.8 , pp. 714-716
    • Gao, Q.1    Wang, L.2    Liang, T.X.3
  • 73
    • 0027478561 scopus 로고
    • Chow YK. Nature 1993; 361: 650.
    • (1993) Nature , vol.361 , pp. 650
    • Chow, Y.K.1
  • 74
    • 0034623020 scopus 로고    scopus 로고
    • Tipranavir inhibits broadly protease inbibitor-resistant HIV-1 clinical samples
    • Larder BA, Hertogs K, Bloor S, et al. Tipranavir inhibits broadly protease inbibitor-resistant HIV-1 clinical samples. AIDS 2000; 4: 1943-8.
    • (2000) AIDS , vol.4 , pp. 1943-1948
    • Larder, B.A.1    Hertogs, K.2    Bloor, S.3
  • 75
    • 0034053044 scopus 로고    scopus 로고
    • Susceptibility to PNU-140690 (tipranavir) of human immunodeficiency virus type 1 isolates derived from patients with multidrug resistance to other protease inhibitors
    • Rusconi S, La Seta Catamancio S, Citterio, P, et al. Susceptibility to PNU-140690 (tipranavir) of human immunodeficiency virus type 1 isolates derived from patients with multidrug resistance to other protease inhibitors. Antimicrob Agents Chemother 2000; 44: 1328-32.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1328-1332
    • Rusconi, S.1    La Seta Catamancio, S.2    Citterio, P.3
  • 76
    • 34249310823 scopus 로고    scopus 로고
    • Development of a tipranavir mutation score: Analysis of protease mutations associated with phenotypic drug susceptibility and antiviral response in Phase II clinical trials
    • Kohlbrenner VM, Hall DB, Schapiro J, et al. Development of a tipranavir mutation score: analysis of protease mutations associated with phenotypic drug susceptibility and antiviral response in Phase II clinical trials. Antivir Ther 2004; 9: S143.
    • (2004) Antivir Ther , vol.9
    • Kohlbrenner, V.M.1    Hall, D.B.2    Schapiro, J.3
  • 77
    • 0242392037 scopus 로고    scopus 로고
    • Tipranavir: A novel non-peptidic protease inhibitor for the treatment of HIV infection
    • Mehandru S, Markowitz M. Tipranavir: a novel non-peptidic protease inhibitor for the treatment of HIV infection. Expert Opin Investig Drugs 2003; 12: 1821-8.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 1821-1828
    • Mehandru, S.1    Markowitz, M.2
  • 78
    • 10744226241 scopus 로고    scopus 로고
    • Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro
    • Koh Y, Nakata H, Maeda K, et al. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother 2003; 47: 3123-9.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3123-3129
    • Koh, Y.1    Nakata, H.2    Maeda, K.3
  • 79
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, et al. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother 2005; 49: 2314-21.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3
  • 80
    • 6344231715 scopus 로고    scopus 로고
    • Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
    • King NM, Prabu-Jeyabalan M, Nalivaika EA, et al. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J Virol 2004; 78: 12012-21.
    • (2004) J Virol , vol.78 , pp. 12012-12021
    • King, N.M.1    Prabu-Jeyabalan, M.2    Nalivaika, E.A.3
  • 81
    • 20144382495 scopus 로고    scopus 로고
    • Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
    • Surleraux DLNG, Tahri A, Verschueren WG, et al. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem 2005; 48: 1813-22.
    • (2005) J Med Chem , vol.48 , pp. 1813-1822
    • Surleraux, D.L.N.G.1    Tahri, A.2    Verschueren, W.G.3
  • 82
    • 34249278252 scopus 로고    scopus 로고
    • Peeters M, Van Baelen B, De Meyer S, et al. TMC114/RTV activity in multiple PI-experienced patients: correlation of baseline genotype, phenotype, pharmacokinetics, and IQ with antiviral activity at day 14 [Abstract 5331. 11th Conference on Retroviruses and Opportunistic Infections 2004, San Francisco, USA.
    • Peeters M, Van Baelen B, De Meyer S, et al. TMC114/RTV activity in multiple PI-experienced patients: correlation of baseline genotype, phenotype, pharmacokinetics, and IQ with antiviral activity at day 14 [Abstract 5331. 11th Conference on Retroviruses and Opportunistic Infections 2004, San Francisco, USA.
  • 83
    • 20644450806 scopus 로고    scopus 로고
    • TMC114/ritonavir substitution for protease inbibitor(s) in a non-suppressive antiretroviral regimen: A 14-day proof-of-principle trial
    • Arasteh K, Clumeck N, Pozniak A, et al. TMC114/ritonavir substitution for protease inbibitor(s) in a non-suppressive antiretroviral regimen: a 14-day proof-of-principle trial. AIDS 2005; 19: 943-7.
    • (2005) AIDS , vol.19 , pp. 943-947
    • Arasteh, K.1    Clumeck, N.2    Pozniak, A.3
  • 84
    • 34249324290 scopus 로고    scopus 로고
    • www.clinicaltrial.gov
  • 85
    • 34249315985 scopus 로고    scopus 로고
    • www.pharma.org
  • 86
    • 34249322807 scopus 로고    scopus 로고
    • www.innovation.org
  • 87
    • 34249284617 scopus 로고    scopus 로고
    • www.pparx.org
  • 88
    • 34249332539 scopus 로고    scopus 로고
    • www.buysafedrugs.info


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.