Intravenous ketoprofen as an adjunct to patient-controlled analgesia morphine in adolescents with thoracic surgery: A placebo controlled double-blinded study

European Journal of Pain

Volumn 11, Issue 6, 2007, Pages 694-699

  Rugyte, Danguole ^a   Kokki, Hannu ^b,c  

^a KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adolescent; Child; Ketoprofen; Morphine; Pain; Pectus carinatum; Pectus excavatum; Postoperative; Surgery

Indexed keywords

KETONAL; KETOPROFEN; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; UNCLASSIFIED DRUG;

ADD ON THERAPY; ADOLESCENT; ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD OXYGEN TENSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; FUNNEL CHEST; HUMAN; INJECTION SITE PAIN; MALE; OXYGEN DESATURATION; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; PIGEON THORAX; POSTOPERATIVE PAIN; PRIORITY JOURNAL; SCHOOL CHILD; SIDE EFFECT; THORAX SURGERY; URINE RETENTION; VISUAL ANALOG SCALE; VOMITING;

ADOLESCENT; AGE FACTORS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG SYNERGISM; FUNNEL CHEST; HUMANS; INJECTIONS, INTRAVENOUS; KETOPROFEN; MORPHINE; NARCOTICS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PLACEBO EFFECT; PLACEBOS; SELF ADMINISTRATION; THORACIC SURGICAL PROCEDURES; TREATMENT OUTCOME;

EID: 34249303773     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2006.11.001     Document Type: Article

References (28)

1. Aubrun F., Langeron O., Heitz D., Coriat P., and Riou B. Randomised, placebo-controlled study of the postoperative effects of ketoprofen after spinal fusion surgery. Acta Anaesthesiol Scand 44 (2000) 934-939
2. Bone M.E., and Fell D. A comparison of rectal diclofenac with intramuscular papaveretum or placebo for pain relief following tonsillectomy. Anaesthesia 43 (1988) 277-280
3. Cardwell M., Siviter G., and Smith A. Non-steroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cohrane Database Syst Rev 18 (2005) CDOO3591
4. Doyle E., Harper I., and Morton N.S. Patient-controlled analgesia with low dose background infusions after lower abdominal surgery in children. Br J Anaesth 71 (1993) 818-822
5. Forrest J.B., Camu F., Greer I.A., Kehlet H., Abdalla M., Bonnet F., et al. POINT Investigators. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth 88 (2002) 227-233
6. Gift A.G., Stanik J., Karpenick, Whitmore K., and Bolgiano C.S. Oxygen saturation in postoperative patients at low risk for hypoxemia: is oxygen therapy needed. Anesth Analg 80 (1995) 368-372
7. Gillespie J.A., and Morton N.S. Patient-controlled analgesia for children: a review. Paediatr Anaesth 2 (1992) 51-59
8. Gottschalk A., Cohen S.P., Yang S., and Ochroch E. Preventing and treating pain after thoracic surgery. Anesthesiology 104 (2006) 594-600
9. Hamunen K., and Maunuksela E.L. Ketorolac does not depress ventilation in children. Paediatr Anaesth 6 (1996) 79
10. Hyllested M., Jones S., Pedersen J.L., and Kehlet H. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 88 (2002) 199-214
11. Jimenez-Andrade J.M., Prtiz M.I., Perez-Urizar J., Aguirre-Banuelos P., Granados-Soto V., and Castaneda-Hernandez G. Synergistic effects between codeine and diclofenac after local, spinal and systemic administration. Pharmacol Biochem Behav 76 (2003) 463-471
12. Kokki H., Nikanne E., and Tuovinen K. I.v. intraoperative ketoprofen in small children during adenoidectomy: a dose finding study. Br J Anaesth 81 (1998) 870-874
13. Kokki H., Tuovinen K., and Hendolin H. The effect of intravenous ketoprofen on postoperative epidural sufentanil analgesia in children. Anesth Analg 88 (1999) 1036-1041
14. Kokki H., Tuovinen K., and Hendolin H. Intravenous ketoprofen and epidural sufentanil analgesia in children after combined spinal-epidural anaesthesia. Acta Anaesthesiol Scand 43 (1999) 775-779
15. Kokki H., Karvinen M., and Jekunen A. Pharmacokinetics of a 24-hour ketoprofen infusion in children. Acta Anaesth Scand 46 (2002) 194-198
16. Kokki H., Purhonen S., Teräsvirta M., and Ylönen P. Ketoprofen for add-on pain treatment to paracetamol in children during strabismus surgery. Clin Drug Invest 24 (2004) 237-244
17. Kurth C.D. Postoperative arterial oxygen saturation: what to expect. Anesth Analg 80 (1995) 1-3
18. Lahtinen P., Kokki H., Hendolin H., Hakala T., and Hynynen N. Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Anesth Analg 95 (2002) 813-819
19. McGrath P.A., Seifert C.E., Speechley K.N., Booth J.C., Stitt L., and Gibson M.C. A new analogue scale for assessing children's pain: an initial validation study. Pain 64 (1996) 435-443
20. McQuay H., and Moore A. An evidence-based resource for pain relief (1998), Oxford University Press, Oxford
21. Moren J., Francois T., Blanloeil Y., and Pinaud M. The effects of a nonsteroidal anti-inflammatory drug (ketoprofen) on morphine respiratory depression: a double-blind, randomized study in volunteers. Anesth Analg 5 (1997) 400-405
22. Morton N.S., and O'Brien K. Analgesic efficacy of paracetamol and diclofenac in children receiving PCA morphine. Br J Anaesth 82 (1999) 715-717
23. Nuss D., Kelly Jr. R.E., Croitoru D.P., and Katz M.E. A 10-year review of a minimally invasive technique for the correction of pectus excavatum. J Pediatr Surg 33 (1998) 545-552
24. Rao A.S., Cardosa M., and Inbasegaran K. Morphine-sparing effect of ketoprofen after abdominal surgery. Anaesth Intensive Care 28 (2000) 22-26
25. Silvanto M., Lappi M., and Rosenberg P.H. Comparison of the opioid-sparing efficacy of diclofenac and ketoprofen for 3 days after knee arthroplasty. Acta Anaesthesiol Scand 46 (2002) 322-328
26. Stone J.G., Cozine K.A., and Wald A. Nocturnal oxygenation during patient-controlled analgesia. Anesth Analg 89 (1999) 104-110
27. Tighe K.E., Webb A.M., and Hobbs G.J. Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity. Anesth Analg 88 (1999) 1137-1142
28. Williams A.M., and Crabbe D.C. Pectus deformities of the anterior chest wall. Paediatr Respir Rev 4 (2003) 237-242