Translational sciences - Turning drug-like molecules into medicines

Drug News and Perspectives

Volumn 19, Issue 10, 2006, Pages 659-663

  Jeffrey, Phil ^a   Karran, Eric ^a   Palmer, Alan ^a   Stemp, Geoffrey ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DONEPEZIL; GALANTAMINE; MEMANTINE; RIVASTIGMINE;

ALZHEIMER DISEASE; ANXIETY; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; COMPUTER MODEL; CONFERENCE PAPER; DEPRESSION; DRUG EFFECT; DRUG INDUSTRY; DRUG PENETRATION; DRUG RESEARCH; ELECTROCARDIOGRAM; GENE EXPRESSION; HEART ARRHYTHMIA; HUMAN; MEDICAL DECISION MAKING; NONHUMAN; QT PROLONGATION; SCHIZOPHRENIA; ZEBRA FISH;

ANIMALS; DRUG DESIGN; DRUG THERAPY; HUMANS; MODELS, ANIMAL; PHARMACOKINETICS; TOXICOLOGY;

EID: 34249300831     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Olson, H., Betton, G., Robinson, D. et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 2000, 32: 56-67.
2. Valentin, J.P., Hoffmann, P., De Clerck, F., Hammond, T.G. and Hondeghem, L. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. J Pharmacol Toxicol Methods 2004, 49: 171-81.
3. O'Brien, P.J., Irwin, W., Diaz, D, et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol 2006, 80: 580-604. Epub 2006 Apr 6.
4. Polli, J. et al. Progr Red Ref Repl Animal Exp 2000, 271-89.
5. Doran, A., Obach, R.S., Smith, B.J. et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005, 33: 165-74. Epub 2004 Oct 22.