The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage

Advances in Space Research

Volumn 39, Issue 6, 2007, Pages 1076-1081

  George, K ^a   Cucinotta, F A ^b  

^a WYLE LABORATORIES   (United States)

^b NASA JOHNSON SPACE CENTER   (United States)

Author keywords

Chromsosome damage; High LET; Radiation; Relative biological effect; Shielding

Indexed keywords

ASTROBIOLOGY; BIOACTIVITY; BLOOD; CHROMOSOMES; HEAVY IONS; IRON; POLYETHYLENES; RADIATION; RADIATION SHIELDING;

CHROMOSOME ABERRATIONS; CHROMOSOME EXCHANGES; CHROMSOSOME DAMAGE; RELATIVE BIOLOGICAL EFFECTS;

CELL DEATH;

EID: 34249300816     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2007.01.004     Document Type: Article

References (26)

1. Alpen E.L., Powers-Risius P., Curtis S.B., and DeGuzman R. Tumorigenic potential of high-Z, high-LET charged particle radiations. Radiat. Res. 88 (1993) 132-143
2. Cucinotta F.A., Manuel F., Jones J., Izsard G., Murrey J., Djojonegoro B., and Wear M. Space radiation and cataracts in astronauts. Radiat. Res. 156 (2001) 460-466
3. Cucinotta F.A., Schimmerling W., Wilson J.W., Peterson L.E., Badhwar G.D., Saganti P., and Dicello J.F. Space radiation cancer risks and uncertainties for Mars missions. Radiat. Res. 156 (2001) 682-688
4. Durante M., George K., Gialanella G., Grossi G., La Tessa C., Manti L., Miller J., Pugliese M., Sampoli P., and Cucinotta F.A. Cytogenetic effects of high-energy iron ions: dependence on shielding thickness and material. Radiat. Res. 164 (2005) 571-576
5. Durante M., Snigiryova G., Akaeva E., Bogomazova A., Druzhinin S., Fedorenko B., Greco O., Novitskaya N., Rubanovich A., Shevchenko V., von Recklinghausen U., and Obe G. Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet. Genome Res. 103 (2003) 40-46
6. Durante M., George K., Wu H., and Cucinotta F.A. Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 158 (2002) 581-590
7. Durante M., Furusawa Y., Majima H., Kawata T., and Gotoh E. Association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiat. Res. 151 (1999) 670-676
8. Fedorenko B.S., Druzhinin S., Yudaeva L., Petrov V., Akatov T., Snigiryova G., Novitskaya N., Shevchenko V., and Rubanovich A. Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station. Adv. Space Res. 27 (2001) 355-359
9. Furusawa Y., Fukutsu K., Aoki M., Itsukaichi H., Eguchi-Kasai K., Ohara H., Yatagai F., Kanai T., and Ando A. Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- (20)Ne-ion beams. Radiat. Res. 154 (2000) 485-496
10. George K., Durante M., Wu H., Willingham V., Badhwar G., and Cucinotta F.A. Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res. 156 (2001) 731-738
11. George K., Wu H., Willingham V., and Cucinotta F.A. The effect of space radiation on the induction of chromosome damage. Physica Medica 17 (2001) S222-S225
12. George K., Wu H., Willingham V., Furusawa Y., Kawata T., and Cucinotta F.A. High- and low-LET induced chromosome damage in human lymphocytes; a time course of aberrations in metaphase and interphase. Int. J. Radiat. Biol. 77 (2001) 175-183
13. George K., Willingham V., Wu H., Gridley D., Nelson G., and Cucinotta F.A. Chromosome aberrations in human lymphocytes induced by 250 MeV protons: effects of dose, dose rate and shielding. Adv. Space Res. 30 (2002) 891-899
14. George K., Durante M., Willingham V., Wu H., Yang T.C., and Cucinotta F.A. Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase in human lymphocytes. Radiat. Res. 160 (2003) 425-435
15. Kanai T., Endo M., Minohara S., Miyahara N., Koyama-ito H., Tomura H., Matsufuji N., Futami Y., Fukumura A., Hiraoka T., Furusawa Y., Ando K., Suzufi M., Soga F., and Kawachi K. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44 (1999) 201-210
16. Kawata T., Durante M., Furusawa Y., George K., Takai N., Wu H., and Cucinotta F.A. Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions. Int. J. Radiat. Biol. 77 2 (2001) 165-174
17. Kiefer J., Stoll U., and Schneider E. Mutation induction by heavy ions. Adv. Space Res. 14 (1994) 257-265
18. Lucas J.M., Poggensee M., and Straume T. The persistence of chromosome translocations in a radiation worker accidentally exposed to tritium. Cytogenet. Cell Genet. 60 (1992) 255-256
19. Nasonova E., Ritter S., Gudowska-Nowak E., and Kraft G. High-LET-induced chromosomal damage: time-dependent expression. Physica Medica 17 (2001) 198-201
20. Ritter S., Nasonova E., Gudowska-Nowak E., Scholz M., and Kraft G. High-LET-induced chromosome aberrations in V79 cells analyzed in first and second post-irradiation metaphases. Int. J. Radiat. Biol. 76 (2000) 149-161
21. Scholz M., Ritter S., and Kraft G. Analysis of chromosome damage based on the time course of aberrations. Int. J. Radiat. Biol. 74 (1998) 325-331
22. Wilson J.W., Cucinotta F.A., Kim M., and Schimmerling W. Optimized shielding for space radiation protection. Phys. Med. 17 (2001) S67-S71
23. Wilson J.A., Thibeault S.A., Cucinotta F.A., Shinn J.L., Kim M., Kiefer R., and Badavi F.F. Issues in protection from galactic cosmic rays. Radiat. Environ. Biophys. 34 (1995) 217-222
24. Wu H., Durante M., George K., and Yang T.C. Induction of chromosome aberrations in human cells by charged particles. Radiat. Res. 148 (1997) S102-S107
25. Yang T.C., Craise L.M., Mei M.T., and Tobias C.A. Neoplastic cell transformation by heavy charged particles. Radiat. Res. 104 (1985) S177-S187
26. Zeitlin C., Heilbronn L., and Miller J. Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron. Radiat. Res. 149 (1998) 560-569