Metabolic flux analysis on arachidonic acid fermentation

Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities

Volumn 21, Issue 2, 2007, Pages 316-321

  Jin, Ming Jie ^a   Huang, He ^a   Zhang, Kun ^a   Yan, Jie ^a   Gao, Zhen ^a  

^a NANJING TECH UNIVERSITY   (China)

Author keywords

Arachidonic acid; Fermentation; Metabolic flux analysis; Mortierella alpina; Synthesis

Indexed keywords

FERMENTATION; FLUXES; GLUCOSE; MATHEMATICAL MODELS; METABOLISM; METABOLITES; SYNTHESIS (CHEMICAL);

ARACHIDONIC ACID; METABOLIC FLUX ANALYSIS; MORTIERELLA ALPINA;

ORGANIC ACIDS;

EID: 34249293004     PISSN: 10039015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. WANG Zhi-ming. The production and application of arachidonic acid [J]. China Food Additives, 2001, (1): 30-33.
2. ZHOU Peng-peng, YU Long-jiang, WU Yuan-xi et al. Fermentation conditions for arachidonic acid production by Mortierella alpina [J]. Industrial Microbiology, 2003, 33(2): 41-45.
3. Sakuradani E, Hirano Y, Kamada N et al. Improvement of arachidonic acid production by mutants with lower n-3 desaturation activity derived from Mortierella alpina 1S-4 [J]. Applied Microbiology and Biotechnology, 2004, 66(3): 243-248.
4. Wynn J P, Ratledge C. Evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of the 18:3 to 20:3 elongase [J]. Microbiology, 2000, 146(9): 2325-2331.
5. GONG Guo-hong, SHANG Yun, GAO Xiang et al. Production of AA oil by microbial fermentation [J]. China Oils, 2002, 27(1): 43-44.
6. Eroshin V K, Dedyukhina E G, Satroutdinov A D et al. Growth-Coupled lipid synthesis in Mortierella alpina LPM 301, a producer of arachidonic acid [J]. Microbiology, 2002, 71(2): 169-172.
7. Bailey J E. Toward a science of metabolic engineering [J]. Science, 1991, 252(5013): 1668-1675.
8. TANG Jun, CAI Shui-hong, YE Qin. Metabolic flux distribution in batch cultivation of Candida krusei for glycerol production [J]. J Chem Eng of Chinese Univ. 2002, 16(1): 58-63.
9. Wynn J P, Hamid A A, Ratledge C et al. Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpina [J]. Microbiology, 2001, 147(10): 2857-2864.
10. Wynn J P, Hamid A A, Ratledge C. The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi [J]. Microbiology, 1999, 145(8): 1911-1917.
11. HUANG He, LI Xue-kun, ZHANG Kun et al. Study on the purification of arachidonic acid by urea inclusion [J]. Chemistry and Bioengineering, 2006, 23(4): 29-31.
12. Kendrick A, Ratledge C. Desaturation of polyunsaturated fatty acids in Mucor circinelloides and the involvement of a novel membrane-bound malic enzyme [J]. Eur J Biochem, 1992, 209(2): 667-673.