Synthesis of furanosyl α-C-glycosides derived from 4-chloro-4-deoxy-α-d-galactose and their cytotoxic activities

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3454-3457

  Yan, Lin ^a   Dai, Gui Fu ^a   Yang, Jian Li ^a   Liu, Feng Wu ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

4 Chloro 4 deoxy d galactose; Crystal structure; Cytotoxicity; Furanosyl C glycosides

Indexed keywords

3 ACETYL 2 METHYL 5 (2' CHLORO DEXTRO GALACTOTETRITOL 1 YL)FURAN; 4 CHLORO 4 DEOXY ALPHA DEXTRO GALACTOSE; ALKYL GROUP; CARBONYL DERIVATIVE; FURAN DERIVATIVE; GALACTOSE; GLYCOSIDE; UNCLASSIFIED DRUG; ZINC CHLORIDE;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CYCLIZATION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHLORIDES; FUCOSE; FURANS; GLYCOSIDES; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC COMPOUNDS;

EID: 34249289729     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.079     Document Type: Article

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22. 2 (Binder, CB150, Germany). Cell cytotoxicity was assessed by MTT assay. Briefly, cells were plated into 96-well-plate (5000 cells/well). The next day compound at various concentrations diluted in culture medium was added (200 μL/well) to the wells. Forty-eight hours later 20 μL of MTT (Sigma Chemical Co., St. Louis, MO) (0.5 mg/mL MTT in PBS) was added and cells were incubated for a further 4 h. Two hundred microliters of DMSO was added to each culture to dissolve the reduced MTT crystals. The MTT-formazan product dissolved in DMSO was estimated by measuring absorbance at 570 nm with a microplate reader (Biotech, Power Wave, CA). Then the inhibitory percentage of each compound at various concentrations was calculated.