Retinal toxicity of triamcinolone's vehicle (benzyl alcohol): An electrophysiologic and electron microscopic study

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 245, Issue 6, 2007, Pages 817-824

  Macky, T A ^a   Helmy, Dina ^b   Shazly, Nihal ^c  

^a Cairo University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NONE   (Egypt)

Author keywords

Electroretinogram; Histopathology; Retinal toxicity; Triamcinolone acetonide

Indexed keywords

BENZYL ALCOHOL; SODIUM CHLORIDE; TRIAMCINOLONE ACETONIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG SAFETY; ELECTRORETINOGRAPHY; EXPERIMENTAL STUDY; EYE TOXICITY; FOLLOW UP; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; INTRAOCULAR PRESSURE ABNORMALITY; NONHUMAN; OPHTHALMOSCOPY; OUTCOME ASSESSMENT; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA BIPOLAR GANGLION CELL; RETINA DISEASE; SLIT LAMP; TRANSMISSION ELECTRON MICROSCOPY; VITREOUS BODY;

ANIMALS; BENZYL ALCOHOL; ELECTRORETINOGRAPHY; GLUCOCORTICOIDS; INJECTIONS; INTRAOCULAR PRESSURE; OPHTHALMOSCOPY; PROSPECTIVE STUDIES; RABBITS; RETINA; TRIAMCINOLONE ACETONIDE; VEHICLES; VITREOUS BODY;

EID: 34249281278     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-006-0459-3     Document Type: Article

References (31)

1. Androudi S, Letko E, Meniconi M, Papadaki T, Ahmed M, Foster CS (2005) Safety and efficacy of intravitreal triamcinolone acetonide for uveitic macular edema. Ocul Immunol Inflamm 13:205-212
2. Antcliff RJ, Spalton DJ, Stanford MR, Graham EM, Ffytche TJ, Marshall J (2001) Intravitreal triamcinolone for uveitic cystoid macular edema: An optical coherence tomography study. Ophthalmology 108:765-772
3. Avci R, Kaderli B (2005) Intravitreal triamcinolone injection for chronic diabetic macular edema with severe hard exudates. Graefes Arch Clin Exp Ophthalmol 21:1-8
4. Bakri SJ, Shah A, Falk NS, Beer PM (2005) Intravitreal preservative-free triamcinolone acetonide for the treatment of macular edema. Eye 19:686-688
5. Bonanomi MT, Susanna R Jr (2005) Intravitreal triamcinolone acetonide as adjunctive treatment for neovascular glaucoma. Clinics 60:347-350
6. Boscia F, Furino C, Dammacco R, Ferreri P, Sborgia L, Sborgia C (2005) Intravitreal triamcinolone acetonide in refractory pseudophakic cystoid macular edema: Functional and anatomic results. Eur J Ophthalmol 15:89-95
7. Danis RP, Ciulla TA, Pratt LM, Anliker W (2000) Intravitreal triamcinolone acetonide in exudative age-related macular degeneration. Retina 20:244-250
8. Drury RA, Walllington EB (1980) Carlton's histological techniques, 5th edn. Oxford University Press, London
9. Garcia-Arumi J, Boixadera A, Giralt J, Martinex-Castillo V, Gomez-Ulla F, Corcostegui B, Garcia-Arumi E (2005) Comparison of different techniques for purification of triamcinolone acetonide suspension for intravitreal use. Br J Ophthalmol 89:1112-1114
10. Gibran SK, Cullinane A, Jungkim S, Cleary PE (2006) Intravitreal triamcinolone for diffuse diabetic macular edema. Eye 20:720-724
11. Glauert AM (1965) The fixation and embedding of biological specimens. In: Key DH (ed) Techniques for electron microscopy, 1st edn. Davis, Philadelphia
12. Hayat MA (1989) Basic techniques for transmission electron microscopy, 1st edn. Academic Press, N.Y.
13. Hernaez-Ortega MC, Soto-Pedre E (2004) A simple and rapid method for purification of triamcinolone acetonide suspension for intravitreal injection. Ophthalmic Surg Lasers Imaging 135:350-351
14. Hida T, Chandler D, Arena JE, Machemer R (1986) Experimental and clinical observations of the intraocular toxicity of commercial corticosteroid preparations. Am J Ophthalmol 101:190-195
15. Jonas JB, Hayler JK, Panda-Jonas S (2000) Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreoretinopathy. Br J Ophthalmol 84:1064-1067
16. Jonas JB, Hayler JK, Sofker A, Panda-Jonas S (2001) Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative diabetic retinopathy. Am J Ophthalmol 131:468-471
17. Jonas JB, Hayler JK, Söker A, Panda-Jonas S (2001) Regression of neovascular iris vessels by intravitreal injection of crystalline cortisone. J Glaucoma 10:284-287
18. Jonas JB, Hayler JK, Panda-Jonas S (2001) Intravitreal injection of crystalline cortisone as treatment of pre-phthisical ocular hypotony. Graef Arch Clin Exp Ophthalmol 239:464-465
19. Jonas JB, Kreissig I, Hugger P, Sauder G, Panda-Jonas S, Degenring R (2003) Intravitreal triamcinolone for exudative age related macular degeneration. Br J Ophthalmol 87:462-468
20. Jonas JB, Akkoyun I, Budde WM, Kreissig I, Degenring RF (2004) Intravitreal reinjection of triamcinolone for exudative age-related macular degeneration. Arch Ophthalmol 122:218-222
21. Lee H, Shah GK (2005) Intravitreal triamcinolone as primary treatment of cystoid macular edema secondary to branch retinal vein occlusion. Retina 25:551-555
22. Marmor ME (1979) Retinal detachment from hyperosmotic intravitreal injections. Invest Ophthalmol Vis Sci 18:1237-1244
23. Martinez JA (2003) Intravitreal triamcinolone acetonide for bilateral acquired parafoveal telangiectasis. Arch Ophthalmol 121:1658-1659
24. McCuen BW 2nd, Bessler M, Tano Y, Chandler D, Machemer R (1981) The lack of toxicity of intravitreally administered triamcinolone acetonide. Am J Ophthalmol 91:785-788
25. Ranson NT, Danis RP, Ciulla TA, Pratt L (2002) Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularization after laser treatment in macular degeneration. Br J Ophthalmol 86:527-529
26. Spaide RF, Sorenson J, Maranan L (2005) Photodynamic therapy with verteporfin combined with intravitreal injection of triamcinolone acetonide for choroidal neovascularization. Ophthalmology 112:301-304
27. Sutter FK, Gillies MC (2003) Intravitreal triamcinolone for radiation-induced macular edema. Arch Ophthalmol 121:1491-1493
28. Williamson TH, O'Donnell A (2005) Intravitreal triamcinolone acetonide for cystoid macular edema in non-ischemic central retinal vein occlusion. Am J Ophthalmol 139:860-866
29. Yang CS, Khawly JA, Hainsworth DP, Chen SN, Ashton P, Guo H, Jaffe GJ (1998) An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. Arch Ophthalmol 116:69-77
30. Young S, Larkin G, Branley M, Lightman S (2001) Safety and efficacy of intravitreal triamcinolone for cystoid macular edema in uveitis. Clin Exp Ophthalmol 29:2-6
31. Xuan B, Wang T, Chiou GCY, Dalinger IL, Shkineva TK, Shevelev SA (2002) Effects of C- nitropyrazoles and C- nitroazoles on ocular blood flow and retinal function recovery after ischemic insult. Acta Pharmacol Sin 23:705-712