Transvaginal diffusion of synthetic peptides

European Journal of Inflammation

Volumn 5, Issue 1, 2007, Pages 15-20

  Basson, E ^a   Van Der Bijl, P ^a   Van Eyk, A D ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Human vaginal mucosa; Peptides; Permeability

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLGLYCEROL; FLUORESCEIN ISOTHIOCYANATE; MDY 19; MEA 5; MICROBICIDE; PCI; PHOSPHATE BUFFERED SALINE; SURFACTANT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION; DRUG DIFFUSION; DRUG PENETRATION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE TRANSPORT; SPECTROFLUOROMETRY; STEADY STATE; TEMPERATURE DEPENDENCE; TIME; VAGINA MUCOSA;

EID: 34249112257     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727X0700500103     Document Type: Article

References (17)

1. Alexander N.J., E. Baker, M. Kaptein, U. Karck, L. Miller and E. Zampaglione. 2004. Why consider vaginal drug administration? Fertil. Steril. 82(1):1.
2. Justin-Temu M., F. Damian, R. Kinget and G. Van den Mooter. 2004. Intravaginal Gels as Drug Delivery Systems. J. Women's Health 13(7):834.
3. Sanders J.M. and H.B. Mathews. 1990. Vaginal absorption of polyvinyl alcohol in Fischer 344 rats. Hum. Exp. Toxicol. 9:71.
4. Veuillez F., Y.N. Kalia, Y. Jacques, J. Deshusses and P. Buri. 2001. Factors and strategies for improving buccal absorption of peptides. Eur. J. Pharm. Biopharm. 51(2):93.
5. Hancock R.E.W. 2001. Cationic peptides: effectors in innate immunity and novel antimicrobials. The Lancet Infect. Dis. Vol. 1(3):156.
6. Yu J. and Y.W. Chien. 1997. Pulmonary drug delivery: physiologic and mechanistic aspects. Crit. Rev. Ther. Drug Carrier Syst. 14(4):395.
7. Powers J.S. and R.E.W. Hancock. 2003. The relationship between peptide structure and antibacterial activity. Peptides 24.1681.
8. Maggio E.T. 2005. Recent developments in intranasal drug delivery technology are creating new vistas for peptide and protein therapeutics. Drug Delivery Companies Report Spring/Summer 2005 ©PharmaVentures Ltd.
9. Van der Bijl P., I.O.C. Thompson and C.A. Squier. 1997. Comparative permeability of human vaginal and buccal mucosa to water. Eur. J. Oral Sci. 105.571.
10. Van der Bijl P., A.D. Van Eyk and I.O.C. Thompson. 1998. Permeation of 17β-estradiol through human vaginal and buccal mucosa. Oral. Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 85:393.
11. Van der Bijl P., A.D. Van Eyk and I.O.C. 1998. Penetration of human vaginal and buccal mucosa by 4.4- and 12-kDa fluorescein-isothiocyanate-labelled dextrans. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod 85:686.
12. Van der Bijl P. and A.D. Van Eyk. 1999. Penetration of benzo[a]pyrene through human buccal and vaginal mucosa. Oral. Surg. Oral Med. Oral Pathol. Oral Radiol. Endod 8:452.
13. Van Eyk A.D. and P. Van der Bijl. 2004. Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa. Arch. Oral Biol. 49(5):387.
14. Motulsky H. 1995. Intuitive Biostatistics. In: Graphpad Software, Oxford University Press, New York.
15. Garg S., R.A. Anderson, C.J. Chany, D.P. Waller, X.H. Diao, K. Vermani and L.J.D. Zaneveld. 2001. Properties of a new acid-buffering bioadhesive vaginal formulation (ACIDFORM). Contraception 64:67.
16. Stratton P. and N.J. Alexander. 1993. Prevention of sexually transmitted infections: physical and chemical barrier methods. Infect. Dis. Clin. North. Am. 7:841.
17. Fleming D.T. and J.N. Wasserheit. 1999. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm. Inf. 75:3.