Vesicular acetylcholine transporter-immunoreactive axon terminals enriched in the pontine nuclei of the mouse

Neuroscience

Volumn 146, Issue 4, 2007, Pages 1869-1878

  Tsutsumi, T ^a   Houtani, T ^a   Toida, K ^b   Kase, M ^a   Yamashita, T ^a   Ishimura, K ^b   Sugimoto, T ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

cholinergic modulation; cholinergic synapse; laterodorsal tegmental nucleus; pedunculopontine tegmental nucleus; pontocerebellar fibers; precerebellar nuclei

Indexed keywords

DIAMINOBENZIDINE; IMMUNOGLOBULIN; POLYCLONAL ANTIBODY; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CUNEATE NUCLEUS; ELECTRON MICROSCOPE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFERIOR OLIVE; LATERAL RETICULAR NUCLEUS; MALE; MOTONEURON; MOUSE; NERVE ENDING; NONHUMAN; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RED NUCLEUS; SOLITARY TRACT NUCLEUS; SYNAPSE VESICLE; THREE DIMENSIONAL IMAGING;

ANIMALS; CHOLINERGIC FIBERS; IMAGING, THREE-DIMENSIONAL; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICROSCOPY, IMMUNOELECTRON; PONS; PRESYNAPTIC TERMINALS; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 34249108327     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.03.019     Document Type: Article

References (37)

1. Aas J.E., Brodal P., Baughman R.W., and Storm-Mathisen J. Projections to the pontine nuclei from choline acetyltransferase-like immunoreactive neurons in the brainstem of the cat. J Comp Neurol 300 (1990) 183-195
2. Adams J.C. Heavy metal intensification of DAB-based HRP reaction product. J Histochem Cytochem 29 (1981) 775
3. Arvidsson U., Riedl M., Elde R., and Meister B. Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J Comp Neurol 378 (1997) 454-467
4. Brodal P., and Bjaalie J.G. Salient anatomic features of the cortico-ponto-cerebellar pathway. Prog Brain Res 114 (1997) 227-249
5. Buckley N.J., Bonner T.I., and Brann M.R. Localization of a family of muscarinic receptor mRNAs in rat brain. J Neurosci 8 (1988) 4646-4652
6. Butcher L.L., and Woolf N.J. Cholinergic neurons and networks revisited. In: Paxinos G. (Ed). The rat nervous system. 3rd edition (2004), Academic Press, San Diego 1257-1268
7. Cortes R., Probst A., and Palacios J.M. Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: brainstem. Neuroscience 12 (1984) 1003-1026
8. Erickson J.D., Varoqui H., Schafer M.K., Modi W., Diebler M.F., Weihe E., Rand J., Eiden L.E., Bonner T.I., and Usdin T.B. Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J Biol Chem 269 (1994) 21929-21932
9. Frey K.A., Ehrenkaufer R.L., and Agranoff B.W. Quantitative in vivo receptor binding. II. Autoradiographic imaging of muscarinic cholinergic receptors. J Neurosci 5 (1985) 2407-2414
10. Garzon M., and Pickel V.M. Dendritic and axonal targeting of the vesicular acetylcholine transporter to membranous cytoplasmic organelles in laterodorsal and pedunculopontine tegmental nuclei. J Comp Neurol 419 (2000) 32-48
11. Gilmor M.L., Nash N.R., Roghani A., Edwards R.H., Yi H., Hersch S.M., and Levey A.I. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci 16 (1996) 2179-2190
12. Gomeza J., Shannon H., Kostenis E., Felder C., Zhang L., Brodkin J., Grinberg A., Sheng H., and Wess J. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 96 (1999) 1692-1697
13. Ichikawa T., Ajiki K., Matsuura J., and Misawa H. Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry. J Chem Neuroanat 13 (1997) 23-39
14. Koch M., Kungel M., and Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp Brain Res 97 (1993) 71-82
15. Lai Y.Y., and Siegel J.M. Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J Neurosci 10 (1990) 2727-2734
16. Levey A.I., Edmunds S.M., Heilman C.J., Desmond T.J., and Frey K.A. Localization of muscarinic m3 receptor protein and M3 receptor binding in rat brain. Neuroscience 63 (1994) 207-221
17. Levey A.I., Kitt C.A., Simonds W.F., Price D.L., and Brann M.R. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11 (1991) 3218-3226
18. Paxinos G., and Franklin K.B.J. The mouse brain in stereotaxic coordinates. 2nd edition (2001), Academic Press, San Diego
19. Perales M., Winer J.A., and Prieto J.J. Focal projections of cat auditory cortex to the pontine nuclei. J Comp Neurol 497 (2006) 959-980
20. Prado V.F., Martins-Silva C., de Castro B.M., Lima R.F., Barros D.M., Amaral E., Ramsey A.J., Sotnikova T.D., Ramirez M.R., Kim H.G., Rossato J.I., Koenen J., Quan H., Cota V.R., Moraes M.F., Gomez M.V., Guatimosim C., Wetsel W.C., Kushmerick C., Pereira G.S., Gainetdinov R.R., Izquierdo I., Caron M.G., and Prado M.A. Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron 51 (2006) 601-612
21. Roghani A., Feldman J., Kohan S.A., Shirzadi A., Gundersen C.B., Brecha N., and Edwards R.H. Molecular cloning of a putative vesicular transporter for acetylcholine. Proc Natl Acad Sci U S A 91 (1994) 10620-10624
22. Roghani A., Shirzadi A., Butcher L.L., and Edwards R.H. Distribution of the vesicular transporter for acetylcholine in the rat central nervous system. Neuroscience 82 (1998) 1195-1212
23. Roghani A., Shirzadi A., Kohan S.A., Edwards R.H., and Butcher L.L. Differential distribution of the putative vesicular transporter for acetylcholine in the rat central nervous system. Brain Res Mol Brain Res 43 (1996) 65-76
24. Rotter A. Cholinergic receptors. In: Bjoerklund A., Hoekfelt T., and Kuhar M.J. (Eds). Handbook of chemical neuroanatomy: Classical transmitters and transmitter receptors in the CNS, part II Vol. 3 (1984), Elsevier, Amsterdam 273-303
25. 3H]propylbenzilylcholine mustard and associated synaptic changes in the hypoglossal and pontine nuclei. Brain Res 180 (1979) 207-224
26. Ruigrok T.J.H. Precerebellar nuclei and red nucleus. In: Paxinos G. (Ed). The rat nervous system. 3rd edition (2004), Academic Press, San Diego 167-204
27. Schafer M.K., Eiden L.E., and Weihe E. Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. I. Central nervous system. Neuroscience 84 (1998) 331-359
28. Schafer M.K., Weihe E., Erickson J.D., and Eiden L.E. Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter. J Mol Neurosci 6 (1995) 225-235
29. Schafer M.K., Weihe E., Varoqui H., Eiden L.E., and Erickson J.D. Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous systems of the rat. J Mol Neurosci 5 (1994) 1-26
30. Spencer Jr. D.G., Horvath E., and Traber J. Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections. Brain Res 380 (1986) 59-68
31. Toida K., Kosaka K., Aika Y., and Kosaka T. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb: IV. Intraglomerular synapses of tyrosine hydroxylase-immunoreactive neurons. Neuroscience 101 (2000) 11-17
32. Usdin T.B., Eiden L.E., Bonner T.I., and Erickson J.D. Molecular biology of the vesicular ACh transporter. Trends Neurosci 18 (1995) 218-224
33. Wamsley J.K., Lewis M.S., Young III W.S., and Kuhar M.J. Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem. J Neurosci 1 (1981) 176-191
34. Weihe E., Tao-Cheng J.H., Schafer M.K., Erickson J.D., and Eiden L.E. Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles. Proc Natl Acad Sci U S A 93 (1996) 3547-3552
35. Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol 44 (2004) 423-450
36. Winn P. How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies. J Neurol Sci 248 (2006) 234-250
37. Woolf N.J., and Butcher L.L. Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum. Brain Res Bull 23 (1989) 519-540