The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop

Acta Crystallographica Section D: Biological Crystallography

Volumn 63, Issue 6, 2007, Pages 665-672

  Biadene, Marianna ^a   Hazemann, Isabelle ^b,f   Cousido, Alexandra ^b   Ginell, Steve ^c   Joachimiak, Andrzej ^c   Sheldrick, George M ^a   Podjarny, Alberto ^b   Schneider, Thomas R ^d,e,g  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^e EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^f INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^g EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Atomic resolution refinement; Diabetes mellitus; Drug design; NADP(H)

Indexed keywords

ALDEHYDE REDUCTASE; ALR2 PROTEIN, HUMAN; CITRIC ACID; LIGAND; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRICITY; ENZYME ACTIVE SITE; GENETICS; HUMAN; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; CATALYTIC DOMAIN; CITRIC ACID; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 34249084888     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444907011997     Document Type: Article

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