메뉴 건너뛰기




Volumn 4, Issue 3, 2007, Pages 355-378

Therapeutic applications of the carbonic anhydrase inhibitors

Author keywords

Anticancer drug; Antiglaucoma agent; Antiobesity agent; Carbonic anhydrase; Enzyme inhibitor; Isozyme; Sulfamate; Sulfamide; Sulfonamide; Tumor progression marker

Indexed keywords

ACETAZOLAMIDE; BENZOLAMIDE; BICARBONATE; BRINZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CELECOXIB; DICLOFENAMIDE; DORZOLAMIDE; ELECTROLYTE; ETHOXZOLAMIDE; INDISULAM; ISOENZYME; METHAZOLAMIDE; PLACEBO; PROTON; SACCHARIN; SULFANILAMIDE; SULFONAMIDE; SULPIRIDE; TOPIRAMATE; UNINDEXED DRUG; VALDECOXIB; ZONISAMIDE;

EID: 34249083904     PISSN: 14750708     EISSN: 1744831X     Source Type: Journal    
DOI: 10.2217/14750708.4.3.355     Document Type: Review
Times cited : (31)

References (120)
  • 2
    • 0034018870 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and their therapeutic potential
    • Supuran CT, Scozzafava A: Carbonic anhydrase inhibitors and their therapeutic potential. Expert Opin. Ther. Pat. 10, 575-600 (2000).
    • (2000) Expert Opin. Ther. Pat , vol.10 , pp. 575-600
    • Supuran, C.T.1    Scozzafava, A.2
  • 3
    • 0036166662 scopus 로고    scopus 로고
    • Applications of carbonic anhydrase inhibitors and activators in therapy
    • Supuran CT, Scozzafava A: Applications of carbonic anhydrase inhibitors and activators in therapy. Expert Opin. Ther. Pat. 12, 217-242 (2002).
    • (2002) Expert Opin. Ther. Pat , vol.12 , pp. 217-242
    • Supuran, C.T.1    Scozzafava, A.2
  • 4
    • 2542592581 scopus 로고    scopus 로고
    • Modulation of carbonic anhydrase activity and its applications in therapy
    • Scozzafava A, Mastrolorenzo A, Supuran CT: Modulation of carbonic anhydrase activity and its applications in therapy. Expert Opin. Ther Pat. 14, 667-702 (2004).
    • (2004) Expert Opin. Ther Pat , vol.14 , pp. 667-702
    • Scozzafava, A.1    Mastrolorenzo, A.2    Supuran, C.T.3
  • 7
    • 16544390541 scopus 로고    scopus 로고
    • Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
    • Pastorekova S, Parkkila S, Pastorek J, Supuran CT: Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J. Enzyme Inhib. Med. Chem. 19, 199-229 (2004).
    • (2004) J. Enzyme Inhib. Med. Chem , vol.19 , pp. 199-229
    • Pastorekova, S.1    Parkkila, S.2    Pastorek, J.3    Supuran, C.T.4
  • 8
    • 0242551296 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors in the treatment and prophylaxis of obesity
    • Supuran CT: Carbonic anhydrase inhibitors in the treatment and prophylaxis of obesity. Expert Opin. Ther Pat. 13, 1545-1550 (2003).
    • (2003) Expert Opin. Ther Pat , vol.13 , pp. 1545-1550
    • Supuran, C.T.1
  • 10
    • 0035971165 scopus 로고    scopus 로고
    • Crystal structure of the "cab"-type β class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum
    • Strop P. Smith KS, Iverson TM, Ferry JG, Rees DC: Crystal structure of the "cab"-type β class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum. J Biol. Chem. 276, 10299-10305 (2001).
    • (2001) J Biol. Chem , vol.276 , pp. 10299-10305
    • Strop, P.1    Smith, K.S.2    Iverson, T.M.3    Ferry, J.G.4    Rees, D.C.5
  • 11
    • 0034599484 scopus 로고    scopus 로고
    • The active site architecture of Pisum sativum β-carbonic anhydrase is a mirror image of that of α-carbonic anhydrases
    • Kimber MS, Pai EF: The active site architecture of Pisum sativum β-carbonic anhydrase is a mirror image of that of α-carbonic anhydrases. EMBO J. 19, 1407-1418 (2000).
    • (2000) EMBO J , vol.19 , pp. 1407-1418
    • Kimber, M.S.1    Pai, E.F.2
  • 12
    • 0034622579 scopus 로고    scopus 로고
    • A closer look at the active site of γ-class carbonic anhydrases: High-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila
    • Iverson TM, Alber BE, Kisker C, Ferry JG, Rees DC: A closer look at the active site of γ-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila. Biochemistry 39, 9222-9231 (2000).
    • (2000) Biochemistry , vol.39 , pp. 9222-9231
    • Iverson, T.M.1    Alber, B.E.2    Kisker, C.3    Ferry, J.G.4    Rees, D.C.5
  • 13
    • 0034633991 scopus 로고    scopus 로고
    • The active site structure of Thalassiosira weissflogii carbonic anhydrase 1
    • Cox EH, McLendon GL, Morel FM et al.: The active site structure of Thalassiosira weissflogii carbonic anhydrase 1. Biochemistry 39, 12128-12130 (2000).
    • (2000) Biochemistry , vol.39 , pp. 12128-12130
    • Cox, E.H.1    McLendon, G.L.2    Morel, F.M.3
  • 14
    • 0034712970 scopus 로고    scopus 로고
    • A biological function for cadmium in marine diatoms
    • Lane TW. Morel FM: A biological function for cadmium in marine diatoms. Proc. Natl Acad. Sci. USA 97, 4627-4631 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4627-4631
    • Lane, T.W.1    Morel, F.M.2
  • 15
    • 0037103151 scopus 로고    scopus 로고
    • The sulfonamide group as an ideal anchor for the design of potent human carbonic anhydrase inhibitors: Role of hydrogen-bonding networks in ligand binding and drug design
    • Abbate F, Supuran CT, Scozzafava A, Orioli P, Stubbs MT, Klebe G: The sulfonamide group as an ideal anchor for the design of potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design. J. Med. Chem. 45, 3583-3587 (2002).
    • (2002) J. Med. Chem , vol.45 , pp. 3583-3587
    • Abbate, F.1    Supuran, C.T.2    Scozzafava, A.3    Orioli, P.4    Stubbs, M.T.5    Klebe, G.6
  • 16
    • 0008290905 scopus 로고    scopus 로고
    • Structure of the human carbonic anhydrase (hCA) isoenzyme I Michigan 1 variant in the absence and in the presence of exogenous zinc ions: The first CA binding two zinc ions
    • Ferraroni M. Briganti F, Chegwidden WR et al.: Structure of the human carbonic anhydrase (hCA) isoenzyme I Michigan 1 variant in the absence and in the presence of exogenous zinc ions: the first CA binding two zinc ions. Biochemistry 41, 6237-6244 (2001).
    • (2001) Biochemistry , vol.41 , pp. 6237-6244
    • Ferraroni, M.1    Briganti, F.2    Chegwidden, W.R.3
  • 17
    • 0035802359 scopus 로고    scopus 로고
    • Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II
    • Kim CY, Chandra PP, Jain A, Christianson DW: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J. Am. Chem. Soc. 123, 9620-9627 (2001).
    • (2001) J. Am. Chem. Soc , vol.123 , pp. 9620-9627
    • Kim, C.Y.1    Chandra, P.P.2    Jain, A.3    Christianson, D.W.4
  • 18
    • 0035859892 scopus 로고    scopus 로고
    • Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
    • Whittington DA, Waheed A, Ulmasov B et al.: Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc. Natl Acad. Sci. USA 98, 9545-9550 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9545-9550
    • Whittington, D.A.1    Waheed, A.2    Ulmasov, B.3
  • 19
    • 0030447975 scopus 로고    scopus 로고
    • Crystal structure of the secretory form of membran-associated human carbonic anhydrase IV at 2.8 Å resolution
    • Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW. Crystal structure of the secretory form of membran-associated human carbonic anhydrase IV at 2.8 Å resolution. Proc. Natl Acad. Sci. USA 93, 13589-13594 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 13589-13594
    • Stams, T.1    Nair, S.K.2    Okuyama, T.3    Waheed, A.4    Sly, W.S.5    Christianson, D.W.6
  • 20
    • 0347339541 scopus 로고
    • Crystallographic studies of carbonic anhydrase inhibition
    • Botrè F, Gros G, Storey BT Eds, VCH, Weinheim, Germany
    • Lindahl M, Vidgren J, Eriksson E et al.: Crystallographic studies of carbonic anhydrase inhibition. In: Carbonic Anhydrase. Botrè F, Gros G, Storey BT (Eds). VCH, Weinheim, Germany 111-118 (1991).
    • (1991) Carbonic Anhydrase , pp. 111-118
    • Lindahl, M.1    Vidgren, J.2    Eriksson, E.3
  • 21
    • 33745644458 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
    • Alterio, V, Vitale RM, Monti SM et al.: Carbonic anhydrase inhibitors: x-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX. J. Am. Chem. Soc. 128, 8329-8335 (2006).
    • (2006) J. Am. Chem. Soc , vol.128 , pp. 8329-8335
    • Alterio, V.1    Vitale, R.M.2    Monti, S.M.3
  • 22
    • 17144375722 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and x-ray crystallographic studies
    • De Simone G, Di Fiore A, Menchise V et al.: Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and x-ray crystallographic studies. Bioorg. Med. Chem, Lett. 15, 2315-2320 (2005).
    • (2005) Bioorg. Med. Chem, Lett , vol.15 , pp. 2315-2320
    • De Simone, G.1    Di Fiore, A.2    Menchise, V.3
  • 23
    • 27944498514 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cycloaxygenase II "selective" inhibitor celecoxib
    • Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT: Carbonic anhydrase inhibitors: valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cycloaxygenase II "selective" inhibitor celecoxib. Bioorg. Med. Chem. Lett. 16, 437-442 (2006).
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 437-442
    • Di Fiore, A.1    Pedone, C.2    D'Ambrosio, K.3    Scozzafava, A.4    De Simone, G.5    Supuran, C.T.6
  • 24
    • 24744467784 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of Inhibitors as exemplified by the x-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
    • Menchise V, De Simone G, Alterio, V et al.: Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of Inhibitors as exemplified by the x-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II. J. Med. Chem. 48, 5721-5727 (2005).
    • (2005) J. Med. Chem , vol.48 , pp. 5721-5727
    • Menchise, V.1    De Simone, G.2    Alterio, V.3
  • 26
    • 5144224910 scopus 로고    scopus 로고
    • Development of sulfonamide carbonic anhydrase inhibitors
    • Supuran CT; Scozzafava A, Conway J Eds, CRC Press, Boca Raton, FL, USA
    • Supuran CT, Scozzafava A, Casini A: Development of sulfonamide carbonic anhydrase inhibitors. In: Carbonic Anhydrase: its Inhibitors and Activators. Supuran CT; Scozzafava A, Conway J (Eds). CRC Press, Boca Raton, FL, USA 67-147 (2004).
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 67-147
    • Supuran, C.T.1    Scozzafava, A.2    Casini, A.3
  • 27
    • 33845896020 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and activators and their use in therapy
    • Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors and activators and their use in therapy. Expert Opin. Ther. Pat. 16, 1627-1644, (2006).
    • (2006) Expert Opin. Ther. Pat , vol.16 , pp. 1627-1644
    • Scozzafava, A.1    Mastrolorenzo, A.2    Supuran, C.T.3
  • 28
    • 2442579987 scopus 로고    scopus 로고
    • Carbonic anhydrases: Catalytic and inhibition mechanisms, distribution and physiological roles
    • Supuran CT; Scozzafava A, Conway J Eds, CRC Press, Boca Raton, FL, USA
    • Supuran CT: Carbonic anhydrases: catalytic and inhibition mechanisms, distribution and physiological roles. In: Carbonic Anhydrase: its Inhibitors and Activators. Supuran CT; Scozzafava A, Conway J (Eds). CRC Press, Boca Raton, FL, USA 1-23 (2004).
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 1-23
    • Supuran, C.T.1
  • 29
    • 0034719437 scopus 로고    scopus 로고
    • Carbonic anhydrase Inhibitors: Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes
    • Scozzafava A, Briganti F, Ilies MA, Supuran CT: Carbonic anhydrase Inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. J. Med. Chem. 43, 292-300 (2000).
    • (2000) J. Med. Chem , vol.43 , pp. 292-300
    • Scozzafava, A.1    Briganti, F.2    Ilies, M.A.3    Supuran, C.T.4
  • 30
    • 0034658561 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV
    • Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV. Bioorg. Med. Chem. Lett. 10, 1117-1120 (2000).
    • (2000) Bioorg. Med. Chem. Lett , vol.10 , pp. 1117-1120
    • Scozzafava, A.1    Supuran, C.T.2
  • 31
    • 0033405657 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(O-aminoalkylcarboxamido)-1,3,4-thiadiazole2-sulfonamide
    • Barbolu M, Supuran CT, Menabuoni L et al.: Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(O-aminoalkylcarboxamido)-1,3,4-thiadiazole2-sulfonamide. J. Enzyme Inhib. 15, 23-46 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 23-46
    • Barbolu, M.1    Supuran, C.T.2    Menabuoni, L.3
  • 32
    • 0034098541 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: The influence of metal ions upon the pharmacological activity
    • Briganti F, Tilli S, Mincione G, Mincione F, Menabuoni L, Supuran CT: Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: the influence of metal ions upon the pharmacological activity. J. Enzyme Inhib. 15, 185-200 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 185-200
    • Briganti, F.1    Tilli, S.2    Mincione, G.3    Mincione, F.4    Menabuoni, L.5    Supuran, C.T.6
  • 33
    • 0033919901 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes
    • Supuran CT, Scozzafava A, Ilies MA, Briganti F: Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes. J. Enzyme Inhib. 15, 381-401 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 381-401
    • Supuran, C.T.1    Scozzafava, A.2    Ilies, M.A.3    Briganti, F.4
  • 34
    • 0033866735 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions
    • Ilies M, Supuran CT Scozzafava A et al.: Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions. Bioorg Med. Chem. 8, 2145-2455 (2000).
    • (2000) Bioorg Med. Chem , vol.8 , pp. 2145-2455
    • Ilies, M.1    Supuran, C.T.2    Scozzafava, A.3
  • 35
    • 0033812912 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Part 86. A QSAR study on some sulfonamide drugs which lower intra-ocular pressure, using the ACE non-linear statistical method
    • Clare BW, Supuran CT: Carbonic anhydrase inhibitors. Part 86. A QSAR study on some sulfonamide drugs which lower intra-ocular pressure, using the ACE non-linear statistical method. Eur. J. Med. Chem. 35, 859-865 (2000).
    • (2000) Eur. J. Med. Chem , vol.35 , pp. 859-865
    • Clare, B.W.1    Supuran, C.T.2
  • 36
    • 0033900940 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives
    • Scozzafava A, Banciu MD, Popescu A, Supuran CT: Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives. J. Enzyme Inhib. 15, 443-453 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 443-453
    • Scozzafava, A.1    Banciu, M.D.2    Popescu, A.3    Supuran, C.T.4
  • 37
    • 0034676310 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action
    • Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT: Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action. J. Med. Chem. 43, 4542-4551 (2000).
    • (2000) J. Med. Chem , vol.43 , pp. 4542-4551
    • Scozzafava, A.1    Menabuoni, L.2    Mincione, F.3    Briganti, F.4    Mincione, G.5    Supuran, C.T.6
  • 38
    • 0034649604 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects
    • Casini A, Scozzafava A, Mincione F, Menabuoni L, Ilies MA, Supuran CT: Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. J. Med. Chem. 43, 4884-4892 (2000).
    • (2000) J. Med. Chem , vol.43 , pp. 4884-4892
    • Casini, A.1    Scozzafava, A.2    Mincione, F.3    Menabuoni, L.4    Ilies, M.A.5    Supuran, C.T.6
  • 39
    • 0033745406 scopus 로고    scopus 로고
    • Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives
    • Mastrolorenzo A, Scozzafava A, Supuran CT: Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives. J. Enzyme Inhib. 15, 517-531 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 517-531
    • Mastrolorenzo, A.1    Scozzafava, A.2    Supuran, C.T.3
  • 40
    • 0033727609 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates
    • Scozzafava A, Banciu MD, Popescu A, Supuran CT: Carbonic anhydrase inhibitors: synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates. J. Enzyme Inhib. 15, 533-546 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 533-546
    • Scozzafava, A.1    Banciu, M.D.2    Popescu, A.3    Supuran, C.T.4
  • 41
    • 0033746355 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors
    • Supuran CT, Scozzafava A: Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors. J. Enzyme Inhib. 15, 597-610 (2000).
    • (2000) J. Enzyme Inhib , vol.15 , pp. 597-610
    • Supuran, C.T.1    Scozzafava, A.2
  • 42
    • 0033818044 scopus 로고    scopus 로고
    • Supuran CT, Scozzafava A: Carbonic anhydrase inhibitors - Part 94. 1,3,4- thiadiazole-2-sulfonamidederivatives as antitumor agents? Eur. J. Med. Chem. 35, 867-874 (2000).
    • Supuran CT, Scozzafava A: Carbonic anhydrase inhibitors - Part 94. 1,3,4- thiadiazole-2-sulfonamidederivatives as antitumor agents? Eur. J. Med. Chem. 35, 867-874 (2000).
  • 44
    • 0035952224 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis of sulfonamides incorporating DTPA tails and of their zinc complexes with powerful topical antiglaucoma properties
    • Scozzafava A, Menabuoni L, Mincione F, Minclone G, Supuran CT: Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating DTPA tails and of their zinc complexes with powerful topical antiglaucoma properties. Bioorg. Med. Chem. Lett. 11, 575-582 (2001).
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 575-582
    • Scozzafava, A.1    Menabuoni, L.2    Mincione, F.3    Minclone, G.4    Supuran, C.T.5
  • 45
    • 0034952892 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5- norbornene-endo-3-carboxy-2-carboxamido moieties
    • Casini A, Mincione F, Ilies MA, Menabuoni L, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5- norbornene-endo-3-carboxy-2-carboxamido moieties. J. Enzyme Inhib. 16, 113-123 (2001).
    • (2001) J. Enzyme Inhib , vol.16 , pp. 113-123
    • Casini, A.1    Mincione, F.2    Ilies, M.A.3    Menabuoni, L.4    Scozzafava, A.5    Supuran, C.T.6
  • 46
    • 0034964139 scopus 로고    scopus 로고
    • Carbonic anhydrase Inhibitors, interaction of boron derivatives with isozymes I and II: A new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies
    • Chazalette C, Riviere-Baudet M, Scozzafava A, Abbate F, Ben Maarouf Z, Supuran CT: Carbonic anhydrase Inhibitors, interaction of boron derivatives with isozymes I and II: a new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies. J. Enzyme Inhib. 16, 125-133 (2001).
    • (2001) J. Enzyme Inhib , vol.16 , pp. 125-133
    • Chazalette, C.1    Riviere-Baudet, M.2    Scozzafava, A.3    Abbate, F.4    Ben Maarouf, Z.5    Supuran, C.T.6
  • 47
    • 0035833062 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties
    • Mincione F, Starnotti M, Menabuoni L, Scozzafava A, Casini A, Supuran CT: Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Bioorg. Med. Chem. Lett. 11, 1787-1791 (2001).
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 1787-1791
    • Mincione, F.1    Starnotti, M.2    Menabuoni, L.3    Scozzafava, A.4    Casini, A.5    Supuran, C.T.6
  • 48
    • 0035225845 scopus 로고    scopus 로고
    • Orbital symmetry in QSAR: Some Schiff's base inhibitors of carbonic anhydrase
    • Supuran CT, Clare BW: Orbital symmetry in QSAR: some Schiff's base inhibitors of carbonic anhydrase. SAR QSAR Environ. Res. 12, 17-29 (2001).
    • (2001) SAR QSAR Environ. Res , vol.12 , pp. 17-29
    • Supuran, C.T.1    Clare, B.W.2
  • 49
    • 0034609778 scopus 로고    scopus 로고
    • Scozzafava A, Supuran CT: Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J. Med. Chem. 43, 3677-3687 (2000).
    • Scozzafava A, Supuran CT: Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J. Med. Chem. 43, 3677-3687 (2000).
  • 50
    • 0348147633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
    • Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX Bioorg. Med. Chem. Lett. 14, 217-223 (2004).
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 217-223
    • Abbate, F.1    Casini, A.2    Owa, T.3    Scozzafava, A.4    Supuran, C.T.5
  • 51
    • 0344193512 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: SAR and x-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV
    • Casini A, Antel J, Abbate F et al.: Carbonic anhydrase inhibitors: SAR and x-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV. Bioorg. Med. Chem. Lett. 13, 841-845 (2003).
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , pp. 841-845
    • Casini, A.1    Antel, J.2    Abbate, F.3
  • 52
    • 0347360282 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride
    • Abbate F, Coetzee A, Casini A, Ciattini S, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: x-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorg. Med. Chem. Lett. 14, 337-341 (2004).
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 337-341
    • Abbate, F.1    Coetzee, A.2    Casini, A.3    Ciattini, S.4    Scozzafava, A.5    Supuran, C.T.6
  • 53
    • 13444259560 scopus 로고    scopus 로고
    • Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent
    • Lloyd MD, Pederick RL, Natesh R et al.: Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochem. J. 385, 715-720 (2005).
    • (2005) Biochem. J , vol.385 , pp. 715-720
    • Lloyd, M.D.1    Pederick, R.L.2    Natesh, R.3
  • 54
    • 0346252639 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
    • Abbate F, Winum JY, Potter BV et al.: Carbonic anhydrase inhibitors: x-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. Bioorg. Med. Chem. Lett. 14, 231-234 (2004).
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 231-234
    • Abbate, F.1    Winum, J.Y.2    Potter, B.V.3
  • 55
    • 1642540579 scopus 로고    scopus 로고
    • Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
    • Weber A, Casini A, Heine A et al.: Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J. Med. Chem. 47, 550-557 (2004).
    • (2004) J. Med. Chem , vol.47 , pp. 550-557
    • Weber, A.1    Casini, A.2    Heine, A.3
  • 57
    • 0034983595 scopus 로고    scopus 로고
    • Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide
    • Seong GJ, Lee SC, Lee JH, Chu YK, Hong YJ: Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide. Ophthalmologica 215, 188-191 (2001).
    • (2001) Ophthalmologica , vol.215 , pp. 188-191
    • Seong, G.J.1    Lee, S.C.2    Lee, J.H.3    Chu, Y.K.4    Hong, Y.J.5
  • 58
    • 0034489369 scopus 로고    scopus 로고
    • Topical dorzolamide 2%/timolol 0.5%: A review of its use in the treatment of open-angle glaucoma
    • Ormrod D, McClellan K: Topical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of open-angle glaucoma. Drugs Aging 17, 477-496 (2000).
    • (2000) Drugs Aging , vol.17 , pp. 477-496
    • Ormrod, D.1    McClellan, K.2
  • 59
    • 1642581027 scopus 로고    scopus 로고
    • Additive effect of latanoprost to the combination of timolol and dorzolamide
    • Susanna R Jr, Nicolela MT, Oga E: Additive effect of latanoprost to the combination of timolol and dorzolamide. J. Glaucoma 9, 183-186 (2000).
    • (2000) J. Glaucoma , vol.9 , pp. 183-186
    • Susanna Jr, R.1    Nicolela, M.T.2    Oga, E.3
  • 60
    • 0035292268 scopus 로고    scopus 로고
    • Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs
    • Gelatt KN, MacKay EO: Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet. Ophthalmol. 4, 61-67 (2001).
    • (2001) Vet. Ophthalmol , vol.4 , pp. 61-67
    • Gelatt, K.N.1    MacKay, E.O.2
  • 61
    • 0034907128 scopus 로고    scopus 로고
    • The International Brinzolamide Adjunctive Study Group: Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension
    • Michaud JE, Friren B; The International Brinzolamide Adjunctive Study Group: Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension. Am. J. Ophthalmol. 132, 235-243 (2001).
    • (2001) Am. J. Ophthalmol , vol.132 , pp. 235-243
    • Michaud, J.E.1    Friren, B.2
  • 62
    • 0033506503 scopus 로고    scopus 로고
    • The role of carbonic anhydrase inhibitors in the management of macular edema
    • Wolfensberger TJ: The role of carbonic anhydrase inhibitors in the management of macular edema. Doc. Ophthalmol. 97, 387-397 (1999).
    • (1999) Doc. Ophthalmol , vol.97 , pp. 387-397
    • Wolfensberger, T.J.1
  • 63
    • 33846991924 scopus 로고    scopus 로고
    • Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
    • Gao BB, Clermont A, Rook S et al.: Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat. Med. 13, 181-188 (2007).
    • (2007) Nat. Med , vol.13 , pp. 181-188
    • Gao, B.B.1    Clermont, A.2    Rook, S.3
  • 64
    • 4544388351 scopus 로고    scopus 로고
    • Cancer-related carbonic anhydrase isozymes and their inhibition
    • Supuran CT, Scozzafava A, Conway J Eds, CRC Press, Boca Raton, FL, USA
    • Pastorekova S, Pastorek J: Cancer-related carbonic anhydrase isozymes and their inhibition. In: Carbonic Anhydrase: its Inhibitors and Activators. Supuran CT, Scozzafava A, Conway J (Eds). CRC Press, Boca Raton, FL, USA 253-280 (2004).
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 253-280
    • Pastorekova, S.1    Pastorek, J.2
  • 65
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • Thiry A, Dogne JM, Masereel B, Supuran CT: Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol. Sci. 27, 566-573 (2006).
    • (2006) Trends Pharmacol. Sci , vol.27 , pp. 566-573
    • Thiry, A.1    Dogne, J.M.2    Masereel, B.3    Supuran, C.T.4
  • 66
    • 8844249356 scopus 로고    scopus 로고
    • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    • Svastova E, Hulikova A, Rafajova M et al.: Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett. 577, 439-445 (2004).
    • (2004) FEBS Lett , vol.577 , pp. 439-445
    • Svastova, E.1    Hulikova, A.2    Rafajova, M.3
  • 67
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • Cecchi A, Hulikova A, Pastorek J et al.: Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J. Med. Chem., 48, 4834-4841 (2005).
    • (2005) J. Med. Chem , vol.48 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3
  • 68
    • 1842628633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX
    • Casey JR, Morgan PE, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J. Med. Chem. 47, 2337-2347 (2004).
    • (2004) J. Med. Chem , vol.47 , pp. 2337-2347
    • Casey, J.R.1    Morgan, P.E.2    Vullo, D.3    Scozzafava, A.4    Mastrolorenzo, A.5    Supuran, C.T.6
  • 69
    • 32844473804 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters
    • Vullo D, Steffansen B, Brodin B, Supuran CT, Scozzafava A, Nielsen CU: Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters. Bioorg. Med. Chem. 14, 2418-2427 (2006).
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 2418-2427
    • Vullo, D.1    Steffansen, B.2    Brodin, B.3    Supuran, C.T.4    Scozzafava, A.5    Nielsen, C.U.6
  • 70
    • 0034009497 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro
    • Parkkila S, Rajaniemi H, Parkkila AK et al.: Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Proc. Natl Acad. Sci. USA 97, 2220-2224 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2220-2224
    • Parkkila, S.1    Rajaniemi, H.2    Parkkila, A.K.3
  • 71
    • 0035164633 scopus 로고    scopus 로고
    • Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours
    • Saarnio J, Parkkila S, Parkkila AK et al.: Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours. J. Hepatol. 35, 643-649 (2001).
    • (2001) J. Hepatol , vol.35 , pp. 643-649
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3
  • 72
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki A, Koukourakis MI, Sivridis E et al.: Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 61, 7992-7998 (2001).
    • (2001) Cancer Res , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3
  • 73
    • 0035881075 scopus 로고    scopus 로고
    • Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
    • Chia SK, Wykoff CC, Watson PH et al.: Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J. Clin. Oncol. 19, 3660-3668 (2001).
    • (2001) J. Clin. Oncol , vol.19 , pp. 3660-3668
    • Chia, S.K.1    Wykoff, C.C.2    Watson, P.H.3
  • 74
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE et al.: Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61, 6394-6399 (2001).
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3
  • 75
    • 0035105565 scopus 로고    scopus 로고
    • Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
    • Wykoff CC, Beasley N, Watson PH et al.: Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. Am. J. Pathol. 158, 1011-1019 (2001).
    • (2001) Am. J. Pathol , vol.158 , pp. 1011-1019
    • Wykoff, C.C.1    Beasley, N.2    Watson, P.H.3
  • 76
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    • Beasley NJ, Wykoff CC, Watson PH et al.: Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Res. 61, 5262-5267 (2001).
    • (2001) Cancer Res , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3
  • 77
    • 0034788480 scopus 로고    scopus 로고
    • Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors
    • Kivela AJ, Saarnio J, Karttunen TJ et al.: Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. Dig. Dis. Sci. 46, 2179-2186 (2001).
    • (2001) Dig. Dis. Sci , vol.46 , pp. 2179-2186
    • Kivela, A.J.1    Saarnio, J.2    Karttunen, T.J.3
  • 78
    • 0033637648 scopus 로고    scopus 로고
    • Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors
    • Parkkila S, Parkkila AK, Saarnio J et al.: Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors. J. Histochem. Cytochem. 48, 1601-1608 (2000).
    • (2000) J. Histochem. Cytochem , vol.48 , pp. 1601-1608
    • Parkkila, S.1    Parkkila, A.K.2    Saarnio, J.3
  • 79
    • 0034803991 scopus 로고    scopus 로고
    • The efficacy of acetazolamide on visual functions in a patient with choroid metastasis of breast carcinoma
    • Sari R, Camci C, Kutlu R, Totan Y, Sevinc A, Buyukberber S: The efficacy of acetazolamide on visual functions in a patient with choroid metastasis of breast carcinoma. Int. J. Clin. Pract. 55, 488-490 (2001).
    • (2001) Int. J. Clin. Pract , vol.55 , pp. 488-490
    • Sari, R.1    Camci, C.2    Kutlu, R.3    Totan, Y.4    Sevinc, A.5    Buyukberber, S.6
  • 80
    • 0024205594 scopus 로고
    • Effect of the carbonic anhydrase inhibitor acetazolamide on lipid synthesis in the locust
    • Spencer IM, Hargreaves I, Chegwidden WR. Effect of the carbonic anhydrase inhibitor acetazolamide on lipid synthesis in the locust. Biochem. Soc. Trans. 16, 973-974 (1988).
    • (1988) Biochem. Soc. Trans , vol.16 , pp. 973-974
    • Spencer, I.M.1    Hargreaves, I.2    Chegwidden, W.R.3
  • 81
    • 0029905838 scopus 로고    scopus 로고
    • Carbonic anhydrase provides bicarbonate for de novo lipogenesis in the locus
    • Chegwidden WR, Spencer IM. Carbonic anhydrase provides bicarbonate for de novo lipogenesis in the locus. Comp. Biochem. Physiol. 115B, 247-254 (1996).
    • (1996) Comp. Biochem. Physiol , vol.115 B , pp. 247-254
    • Chegwidden, W.R.1    Spencer, I.M.2
  • 82
    • 0034577820 scopus 로고    scopus 로고
    • The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals
    • Chegwidden WR, Edwards Y, Carter N Eds, Birkhäuser Verlag, Basel, Switzerland
    • Chegwidden WR, Dodgson SJ, Spencer IM: The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals. In: The Carbonic Anhydrases - New Horizons. Chegwidden WR, Edwards Y, Carter N (Eds). Birkhäuser Verlag, Basel, Switzerland 343-363 (2000).
    • (2000) The Carbonic Anhydrases - New Horizons , pp. 343-363
    • Chegwidden, W.R.1    Dodgson, S.J.2    Spencer, I.M.3
  • 84
    • 0029933488 scopus 로고    scopus 로고
    • Differentiation-dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes
    • Hazen SA, Waheed A, Sly WS, Lanoue KF, Lynch CJ: Differentiation-dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes. FASEB J. 10, 481-490 (1996).
    • (1996) FASEB J , vol.10 , pp. 481-490
    • Hazen, S.A.1    Waheed, A.2    Sly, W.S.3    Lanoue, K.F.4    Lynch, C.J.5
  • 85
    • 0029035048 scopus 로고
    • The structure and mechanism of action of pyruvate carboxylase
    • Atwood PV: The structure and mechanism of action of pyruvate carboxylase. Int. J. Biochem. Cell Biol. 27, 231-249 (1995).
    • (1995) Int. J. Biochem. Cell Biol , vol.27 , pp. 231-249
    • Atwood, P.V.1
  • 86
    • 0030422424 scopus 로고    scopus 로고
    • Short-term regulation of acetyl CoA carboxylase in tissues of higher animals
    • Alldred JB, Reilly KE: Short-term regulation of acetyl CoA carboxylase in tissues of higher animals. Prog. Lipid Res. 35, 371-385 (1997).
    • (1997) Prog. Lipid Res , vol.35 , pp. 371-385
    • Alldred, J.B.1    Reilly, K.E.2
  • 87
    • 0034572878 scopus 로고    scopus 로고
    • Membrane transport and provision of substrates for carbonic anhydrase in vertebrates
    • Chegwidden WR, Edwards Y, Carter N Eds, Birkhäuser Verlag, Basel, Switzerland
    • Forster RE, Dodgson SJ: Membrane transport and provision of substrates for carbonic anhydrase in vertebrates. In: The Carbonic Anhydrases - New Horizons. Chegwidden WR, Edwards Y, Carter N (Eds). Birkhäuser Verlag, Basel, Switzerland 263-280 (2000).
    • (2000) The Carbonic Anhydrases - New Horizons , pp. 263-280
    • Forster, R.E.1    Dodgson, S.J.2
  • 88
    • 0009125899 scopus 로고    scopus 로고
    • An overview of the distribution and function of carbonic anhydrase isozymes in mammals
    • Chegwidden WR, Edwards Y, Carter N Eds, Birkhäuser Verlag, Basel, Switzerland
    • Parkkila S: An overview of the distribution and function of carbonic anhydrase isozymes in mammals. In: The Carbonic Anhydrases - New Horizons. Chegwidden WR, Edwards Y, Carter N (Eds). Birkhäuser Verlag, Basel, Switzerland 79-94 (2000).
    • (2000) The Carbonic Anhydrases - New Horizons , pp. 79-94
    • Parkkila, S.1
  • 89
    • 1242348311 scopus 로고    scopus 로고
    • Role of carbonic anhydrase and its inhibitors in biological science related to gastroenterology, neurology and nephrology
    • Supuran CT, Scozzafava A, Conway J Eds, CRC Press, Boca Raton, FL, USA
    • Parkkila S, Parkkila AK, Kivelä J: Role of carbonic anhydrase and its inhibitors in biological science related to gastroenterology, neurology and nephrology, In: Carbonic Anhydrase: its Inhibitors and Activators. Supuran CT, Scozzafava A, Conway J (Eds). CRC Press, Boca Raton, FL, USA 283-301 (2004).
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 283-301
    • Parkkila, S.1    Parkkila, A.K.2    Kivelä, J.3
  • 90
    • 0033014606 scopus 로고    scopus 로고
    • Mood stabilization and weight loss with topiramate
    • Gordon A, Price LH: Mood stabilization and weight loss with topiramate. Am. J. Psychiatry 156, 968-969 (1999).
    • (1999) Am. J. Psychiatry , vol.156 , pp. 968-969
    • Gordon, A.1    Price, L.H.2
  • 91
    • 0034576649 scopus 로고    scopus 로고
    • Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats
    • Picard F, Deshaies Y, Lalonde J, Samson P, Richard D: Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats. Obesity Res. 8, 656-663 (2000).
    • (2000) Obesity Res , vol.8 , pp. 656-663
    • Picard, F.1    Deshaies, Y.2    Lalonde, J.3    Samson, P.4    Richard, D.5
  • 92
    • 1242318777 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides
    • Vullo D, Franchi M, Gallori E, Antel J, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides. J. Med. Cbem. 47, 1272-1279 (2004).
    • (2004) J. Med. Cbem , vol.47 , pp. 1272-1279
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Antel, J.4    Scozzafava, A.5    Supuran, C.T.6
  • 93
    • 28144452672 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors
    • Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J. Med. Chem. 48, 7860-7866 (2005).
    • (2005) J. Med. Chem , vol.48 , pp. 7860-7866
    • Nishimori, I.1    Vullo, D.2    Innocenti, A.3    Scozzafava, A.4    Mastrolorenzo, A.5    Supuran, C.T.6
  • 94
    • 33746805519 scopus 로고    scopus 로고
    • Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents
    • Albaugh VL, Henry CR, Bello NT et al.: Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity 14, 36-51 (2006).
    • (2006) Obesity , vol.14 , pp. 36-51
    • Albaugh, V.L.1    Henry, C.R.2    Bello, N.T.3
  • 95
    • 28844465417 scopus 로고    scopus 로고
    • Management of atypical antipsychotic-induced weight gain in schizophrenic patients with topiramate
    • Lin YH, Liu CY, Hsiao MC: Management of atypical antipsychotic-induced weight gain in schizophrenic patients with topiramate. Psychiatry Clin. Neurosci. 59, 613-615 (2005).
    • (2005) Psychiatry Clin. Neurosci , vol.59 , pp. 613-615
    • Lin, Y.H.1    Liu, C.Y.2    Hsiao, M.C.3
  • 96
    • 29144493109 scopus 로고    scopus 로고
    • Zonisamide: Review of its use in epilepsy therapy
    • Zareba G: Zonisamide: review of its use in epilepsy therapy. Drug Today (Barc.) 41, 589-597 (2005).
    • (2005) Drug Today (Barc.) , vol.41 , pp. 589-597
    • Zareba, G.1
  • 97
    • 14644423907 scopus 로고    scopus 로고
    • Clinical experience with Topiramate to counteract neuroleptic induced weight gain in 10 individuals with autistic spectrum disorders
    • Canitano R: Clinical experience with Topiramate to counteract neuroleptic induced weight gain in 10 individuals with autistic spectrum disorders. Brain Dev. 27, 228-232 (2005).
    • (2005) Brain Dev , vol.27 , pp. 228-232
    • Canitano, R.1
  • 98
    • 0043093909 scopus 로고    scopus 로고
    • Zonisamide effective for weight loss in women
    • Kim CS: Zonisamide effective for weight loss in women. J. Fam. Pract. 52, 600-601 (2003).
    • (2003) J. Fam. Pract , vol.52 , pp. 600-601
    • Kim, C.S.1
  • 99
    • 0038516857 scopus 로고    scopus 로고
    • Zonisamide for weight loss in obese adults: A randomized controlled trial
    • Gadde KM, Franciscy DM, Wagner HR 2nd, Krishnan KR: Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA 289, 1820-1825 (2003).
    • (2003) JAMA , vol.289 , pp. 1820-1825
    • Gadde, K.M.1    Franciscy, D.M.2    Wagner 2nd, H.R.3    Krishnan, K.R.4
  • 100
    • 0033958202 scopus 로고    scopus 로고
    • Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis
    • Tawil R, McDermott MP, Brown R Jr et al.: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann. Neurol. 47, 46-53 (2000).
    • (2000) Ann. Neurol , vol.47 , pp. 46-53
    • Tawil, R.1    McDermott, M.P.2    Brown Jr, R.3
  • 101
    • 0034643902 scopus 로고    scopus 로고
    • Pharmacologic treatment of essential tremor
    • Koller WC, Hristova A, Brin M: Pharmacologic treatment of essential tremor. Neurology 54(Suppl 4), S30-S38 (2000).
    • (2000) Neurology , vol.54 , Issue.SUPPL. 4
    • Koller, W.C.1    Hristova, A.2    Brin, M.3
  • 102
    • 0035852676 scopus 로고    scopus 로고
    • Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain
    • Parkkila S, Parkkila AK, Rajaniemi H et al.: Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. Proc. Natl Acad Sci. USA 98, 1918-1923 (2001).
    • (2001) Proc. Natl Acad Sci. USA , vol.98 , pp. 1918-1923
    • Parkkila, S.1    Parkkila, A.K.2    Rajaniemi, H.3
  • 103
    • 0034932304 scopus 로고    scopus 로고
    • Preferential acetazolamide-induced vasodilation based on vessel size and organ: Confirmation of peripheral vasodilation with use of colored microspheres
    • Taki K, Oogushi K, Hirahara K, Gai X, Nagashima F, Tozuka K: Preferential acetazolamide-induced vasodilation based on vessel size and organ: confirmation of peripheral vasodilation with use of colored microspheres. Angiology 52, 483-488 (2001).
    • (2001) Angiology , vol.52 , pp. 483-488
    • Taki, K.1    Oogushi, K.2    Hirahara, K.3    Gai, X.4    Nagashima, F.5    Tozuka, K.6
  • 104
    • 0034492434 scopus 로고    scopus 로고
    • Zinc deficiency and taste dysfunction; contribution of carbonic anhydrase, a zinc-metalloenzyme, to normal taste sensation
    • Komai M, Goto T, Suzuki H, Takeda T, Furukawa Y: Zinc deficiency and taste dysfunction; contribution of carbonic anhydrase, a zinc-metalloenzyme, to normal taste sensation. Biofactors 12, 65-70 (2000).
    • (2000) Biofactors , vol.12 , pp. 65-70
    • Komai, M.1    Goto, T.2    Suzuki, H.3    Takeda, T.4    Furukawa, Y.5
  • 106
    • 33846458646 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors
    • Nishimori I, Minakuchi T, Onishi S, Vullo D, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. J. Med. Chem. 50, 381-388 (2007).
    • (2007) J. Med. Chem , vol.50 , pp. 381-388
    • Nishimori, I.1    Minakuchi, T.2    Onishi, S.3    Vullo, D.4    Scozzafava, A.5    Supuran, C.T.6
  • 107
    • 0034099354 scopus 로고    scopus 로고
    • Elevated serum levels of antibodies to carbonic anhydrase I and II in patients with chronic pancreatitis
    • Frulloni L, Bovo P, Brunelli S et al.: Elevated serum levels of antibodies to carbonic anhydrase I and II in patients with chronic pancreatitis. Pancreas 20, 382-388 (2000).
    • (2000) Pancreas , vol.20 , pp. 382-388
    • Frulloni, L.1    Bovo, P.2    Brunelli, S.3
  • 108
    • 0029965708 scopus 로고    scopus 로고
    • Acetazolamide in the treatment of seizures
    • Reiss WG, Oles KS: Acetazolamide in the treatment of seizures. Ann. Pharmacother. 30, 514-519 (1996).
    • (1996) Ann. Pharmacother , vol.30 , pp. 514-519
    • Reiss, W.G.1    Oles, K.S.2
  • 109
    • 0036211076 scopus 로고    scopus 로고
    • Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies
    • Katayama F, Miura H, Takanashi S: Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies. Brain Dev. 24, 150-154 (2002).
    • (2002) Brain Dev , vol.24 , pp. 150-154
    • Katayama, F.1    Miura, H.2    Takanashi, S.3
  • 110
    • 1242348311 scopus 로고    scopus 로고
    • Role of carbonic anhydrase and its inhibitors in gastroenterology, neurology and nephrology
    • Supuran CT, Scozzafava A, Conway J Eds, CRC Press, Boca Raton, FL, USA
    • Parkkila S, Parkkila AK, Kivela J: Role of carbonic anhydrase and its inhibitors in gastroenterology, neurology and nephrology. In: Carbonic Anhydrase: its Inhibitors and Activators. Supuran CT, Scozzafava A, Conway J (Eds). CRC Press, Boca Raton, FL, USA 283-301 (2004).
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 283-301
    • Parkkila, S.1    Parkkila, A.K.2    Kivela, J.3
  • 111
    • 7044271164 scopus 로고    scopus 로고
    • Zonisamide: Chemistry, mechanism of action, and pharmacokinetics
    • Leppik IE: Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure 13(Suppl. 1), S5-9 (2004).
    • (2004) Seizure , vol.13 , Issue.SUPPL. 1
    • Leppik, I.E.1
  • 112
    • 0036171793 scopus 로고    scopus 로고
    • Two new actions of topiramate: Inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance
    • Herrero AI, Del Olmo N, Gonzalez-Escalada JR, Solis JM: Two new actions of topiramate: inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance. Neuropharmacology 42, 210-220 (2002).
    • (2002) Neuropharmacology , vol.42 , pp. 210-220
    • Herrero, A.I.1    Del Olmo, N.2    Gonzalez-Escalada, J.R.3    Solis, J.M.4
  • 113
    • 2142808112 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity
    • Ilies MA, Masereel B, Rolin S et al.: Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. Bioorg. Med. Chem. Lett, 12, 2717-2726 (2004).
    • (2004) Bioorg. Med. Chem. Lett , vol.12 , pp. 2717-2726
    • Ilies, M.A.1    Masereel, B.2    Rolin, S.3
  • 115
    • 16244364782 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides
    • Vullo D, Voipio J, Innocenti A et al.: Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 15, 971-976 (2005).
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 971-976
    • Vullo, D.1    Voipio, J.2    Innocenti, A.3
  • 116
    • 0027159771 scopus 로고
    • Intracellular carbonic anhydrase activity and its role in GABA-incluced acidosis in isolated rat hippocampal pyramidal neurones
    • Pasternack M, Voipio, J, Kaila K: Intracellular carbonic anhydrase activity and its role in GABA-incluced acidosis in isolated rat hippocampal pyramidal neurones. Acta Physiol. Scand. 148, 229-231 (1993).
    • (1993) Acta Physiol. Scand , vol.148 , pp. 229-231
    • Pasternack, M.1    Voipio, J.2    Kaila, K.3
  • 117
    • 0036278511 scopus 로고    scopus 로고
    • Effects of antiepileptic drugs on axtracellular pH regulation in the hippocampal CA1 region in vivo
    • Aribi AM, Stringer JL: Effects of antiepileptic drugs on axtracellular pH regulation in the hippocampal CA1 region in vivo. Epilepsy Res. 49, 143-151 (2002).
    • (2002) Epilepsy Res , vol.49 , pp. 143-151
    • Aribi, A.M.1    Stringer, J.L.2
  • 118
    • 3543025081 scopus 로고    scopus 로고
    • Acetazolamide plus low-dose dexamethasone is better than acetazolamide alone to ameliorate symptoms of acute mountain sickness
    • Bernhard WN, Schalik LM, Delaney PA, Bernhard TM, Barnas GM: Acetazolamide plus low-dose dexamethasone is better than acetazolamide alone to ameliorate symptoms of acute mountain sickness. Aviat. Space Environ. Med. 69, 883-886 (1998).
    • (1998) Aviat. Space Environ. Med , vol.69 , pp. 883-886
    • Bernhard, W.N.1    Schalik, L.M.2    Delaney, P.A.3    Bernhard, T.M.4    Barnas, G.M.5
  • 120
    • 0029597403 scopus 로고
    • A trek to the top: A review of acute mountain sickness
    • Porcelli MJ, Gugelchuk GM: A trek to the top: a review of acute mountain sickness. J. Am. Osteopath. Assoc. 95, 718-720 (1995).
    • (1995) J. Am. Osteopath. Assoc , vol.95 , pp. 718-720
    • Porcelli, M.J.1    Gugelchuk, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.