Quinidine in short QT syndrome: An old drug for a new disease

Journal of Cardiovascular Electrophysiology

Volumn 18, Issue 6, 2007, Pages 665-666

  Kaufman, Elizabeth S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLECAINIDE; PINACIDIL; QUINIDINE; SOTALOL;

ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EXPERIMENTAL STUDY; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; ISOLATED HEART; NONHUMAN; NOTE; PRIORITY JOURNAL; SHORT QT SYNDROME;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FLECAINIDE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; QUINIDINE; RABBITS; SOTALOL; TREATMENT OUTCOME;

EID: 34249055555     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2007.00815.x     Document Type: Note

References (16)

1. Gaita F, Giustetto C, Bianchi F, Wolpert C, Schimpf R, Riccardi R, Grossi S, Richiardi E, Borggrefe M : Short QT syndrome - A familial cause of sudden death. Circulation 2003 108 : 965 970.
2. Schimpf R, Wolpert C, Bianchi F, Giustetto C, Gaita F, Bauersfeld U, Borggrefe M : Congenital short QT syndrome and implantable cardioverter defibrillator treatment: Inherent risk for inappropriate shock delivery. J Cardiovasc Electrophysiol 2003 14 : 1273 1277.
3. Milberg P, Tegelkamp R, Osada N, Schimpf R, Wolpert C, Breithardt G, Borggrefe M, Eckardt L : Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome. J Cardiovasc Electrophysiol 2007 18 : 658 664.
4. Gussak I, Brugada P, Brugada J, Wright RS, Kopecky SL, Chaitman BR, Bjerregaard P : Idiopathic short QT interval: A new clinical syndrome? Cardiology 2000 94 : 99 102.
5. Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M, Menendez TM, Brugada J, Pollevick GD, Wolpert C, Burashnikov E, Matsuo K, Wu YS, Guerchicoff A, Bianchi F, Giustetto C, Schimpf R, Brugada P, Antzelevitch C : Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation 2004 109 : 30 35.
6. Bellocq C, van Ginneken AC, Bezzina CR, Alders M, Escande D, Mannens MM, Baro I, Wilde AA : Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation 2004 109 : 2394 2397.
7. Priori SG, Pandit SV, Rivolta I, Berenfeld O, Ronchetti E, Dhamoon A, Napolitano C, Anumonwo J, di Barletta MR, Gudapakkam S, Bosi G, Stramba-Badiale M, Jalife J : A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res 2005 96 : 800 807.
8. Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y, Guerchicoff A, Pfeiffer R, Oliva A, Wollnik B, Gelber P, Bonaros EP Jr., Burashnikov E, Wu Y, Sargent JD, Schickel S, Oberheiden R, Bhatia A, Hsu LF, Haissaguerre M, Schimpf R, Borggrefe M, Wolpert C : Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 2007 115 : 442 449.
9. Viskin S, Zeltser D, Ish-Shalom M, Katz A, Glikson M, Justo D, Tekes-Manova D, Belhassen B : Is idiopathic ventricular fibrillation a short QT syndrome? Comparison of QT intervals of patients with idiopathic ventricular fibrillation and healthy controls. Heart Rhythm 2004 1 : 587 591.
10. Gaita F, Giustetto C, Bianchi F, Schimpf R, Haissaguerre M, Calo L, Brugada R, Antzelevitch C, Borggrefe M, Wolpert C : Short QT syndrome: Pharmacological treatment. J Am Coll Cardiol 2004 43 : 1494 1499.
11. Wolpert C, Schimpf R, Giustetto C, Antzelevitch C, Cordeiro J, Dumaine R, Brugada R, Hong K, Bauersfeld U, Gaita F, Borggrefe M : Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol 2005 16 : 54 58.
12. McPate MJ, Duncan RS, Witchel HJ, Hancox JC : Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome. J Mol Cell Cardiol 2006 41 : 563 566.
13. Hong K, Bjerregaard P, Gussak I, Brugada R : Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. J Cardiovasc Electrophysiol 2005 16 : 394 396.
14. Bjerregaard P, Gussak I : Short QT syndrome. Ann Noninvasive Electrocardiol 2005 10 : 436 440.
15. Lu LX, Zhou W, Zhang X, Cao Q, Yu K, Zhu C : Short QT syndrome: A case report and review of literature. Resuscitation 2006 71 : 115 121.
16. Extramiana F, Antzelevitch C : Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome. Circulation 2004 110 : 3661 3666.