Pathogenesis of SLE dermatitis - A reflection of the process in SLE nephritis?

Current Rheumatology Reviews

Volumn 3, Issue 2, 2007, Pages 159-165

  Fismen, Silje ^a,b   Petter Rekvig, Ole ^a,b   Synnøve Mortensen, Elin ^a,b  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Apoptosis; Autoantibodies; Dermatitis; Nephritis; Nucleosomes; SLE

Indexed keywords

AUTOANTIBODY; CD59 ANTIGEN; CHEMOKINE; CYCLINE; CYTOKINE; DNA FRAGMENT; DOUBLE STRANDED DNA ANTIBODY; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; HISTONE; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53; RO ANTIBODY;

ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; APOPTOSIS; CHROMATIN; CYTOKINE PRODUCTION; DISCOID LUPUS ERYTHEMATOSUS; DISEASE CLASSIFICATION; DNA CLEAVAGE; DNA DETERMINATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOPATHOLOGY; IN VIVO STUDY; KERATINOCYTE; LUPUS ERYTHEMATOSUS NEPHRITIS; NICK END LABELING; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN TARGETING; RADIATION EXPOSURE; REVIEW; SKIN LUPUS ERYTHEMATOSUS; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET B RADIATION;

EID: 34249037843     PISSN: 15733971     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339707780619412     Document Type: Review

References (78)

1. Rekvig OP, Kalaaji M, Nossent H. Anti-DNA antibody subpopulations and lupus nephritis. Autoimmun Rev 2004; 3: 1-6.
2. Berden JH, Licht R, van Bruggen MC, Tax WJ. Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr Opin Nephrol Hypertens 1999; 8: 299-306.
3. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001; 7: 1189-1193.
4. Huerta PT, Kowal C, DeGiorgio LA, Volpe BT, Diamond B. Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci USA 2006; 103: 678-683.
5. Grootscholten C, van Bruggen MC, van der Pijl JW, et al. Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. Arthritis Rheum 2003; 48: 1355-1362.
6. van Bruggen MC, Kramers C, Hylkema MN, Smeenk RJ, Berden JH. Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/1 mice. Clin Exp Immunol 1996; 105: 132-139.
7. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277.
8. Kalaaji M, Sturfelt G, Mjelle JE, Nossent H, Rekvig OP. Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. Arthritis Rheum 2006; 54: 914-926.
9. Kalaaji M, Mortensen E, Jorgensen L, Olsen R, Rekvig OP. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells. Am J Pathol 2006; 168: 1779-1792.
10. Kalaaji M, Fenton K, Mortensen ES, et al. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int in press 2007.
11. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
12. Noel LH, Droz D, Rothfield NF. Clinical and serologic significance of cutaneous deposits of immunoglobulins, C3, and C1q in SLE patients with nephritis. Clin Immunol Immunopathol 1978; 10: 381-388.
13. Licht R, Dieker JW, Jacobs CW, Tax WJ, Berden JH. Decreased phagocytosis of apoptotic cells in diseased SLE mice. J Autoimmun 2004; 22: 139-145.
14. Berden JH. Lupus nephritis: consequence of disturbed removal of apoptotic cells? Neth J Med 2003; 61: 233-238.
15. Licht R, van Bruggen MC, Oppers-Walgreen B, Rijke TP, Berden J. Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration. Arthritis Rheum 2001; 44: 1320-1330.
16. Amoura Z, Chabre H, Koutouzov S, et al. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum 1994; 37: 1684-1688.
17. Berden JH. Lupus nephritis. Kidney Int 1997;52:538-558.
18. Mohan C, Adams S, Stanik V, Datta SK. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 1993; 177: 1367-1381.
19. Voll RE, Roth EA, Girkontaite I, et al. Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis Rheum 1997; 40: 2162-2171.
20. Roberts JL, Wyatt RJ, Schwartz MM, Lewis EJ. Differential characteristics of immune-bound antibodies in diffuse proliferative and membranous forms of lupus glomerulonephritis. Clin Immunol Immunopathol 1983; 29: 223-241.
21. Su CF, Chen HH, Yeh JC, Chen SC, Liu CC, Tzen CY. Ultrastructural 'fingerprint' in cryoprecipitates and glomerular deposits: a clinicopathologic analysis of fingerprint deposits. Nephron 2002; 90: 37-42.
22. Winfield JB, Faiferman I, Koffler D. Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis. J Clin Invest 1977; 59: 90-96.
23. Pablos JL, Santiago B, Galindo M, Carreira PE, Ballestin C, Gomez-Reino JJ. Keratinocyte apoptosis and p53 expression in cutaneous lupus and dermatomyositis. J Pathol 1999; 188:63-68.
24. Chung JH, Kwon OS, Eun HC, et al. Apoptosis in the pathogenesis of cutaneous lupus erythematosus. Am J Dermatopathol 1998; 20: 233-241.
25. Casciola-Rosen LA, Anhalt G. Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317-1330.
26. Kuhn A, Herrmann M, Kleber S, et al. Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum 2006; 54: 939-950.
27. Burnham TK, Neblett TR, Fine GG. The application of the fluorescent antibody technique to the investigation of lupus erythematosus and various dermatoses. J Invest Dermatol 1963; 41: 451-456.
28. Cormane RH. "Bound" globulin in the skin of patients with chronic discoid lupus erythematosus and systemic lupus erythematosus. Lancet 1964; 18: 534-535.
29. Gilliam JN, Sontheimer RD. Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 1981; 4: 471-475.
30. Kuhn A, Sonntag M, Richter-Hintz D, et al. Phototesting in lupus erythematosus tumidus - review of 60 patients. Photochem Photobiol 2001; 73: 532-536.
31. Sontheimer RD, Thomas JR, Gilliam JN. Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset. Arch Dermatol 1979; 115: 1409-1415.
32. Sontheimer RD. The lexicon of cutaneous lupus erythematosus - a review and personal perspective on the nomenclature and classification of the cutaneous manifestations of lupus erythematosus. Lupus 1997; 6: 84-95.
33. Lee LA, Roberts CM, Frank MB, McCubbin VR, Reichlin M. The autoantibody response to Ro/SSA in cutaneous lupus erythematosus. Arch Dermatol 1994; 130: 1262-1268.
34. Shapiro M, Sosis AC, Junkins-Hopkins JM, Werth VP. Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: a review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual. Int J Dermatol 2004; 43: 87-94.
35. Jerdan MS, Hood AF, Moore GW, Callen JP. Histopathologic comparison of the subsets of lupus erythematosus. Arch Dermatol 1990; 126: 52-55.
36. Fabre VC, Lear S, Reichlin M, Hodge SJ, Callen JP. Twenty percent of biopsy specimens from sun-exposed skin of normal young adults demonstrate positive immunofluorescence. Arch Dermatol 1991; 127: 1006-1011.
37. Alahlafi A, Wordsworth P, Wojnarowska F. Activation/inactivation of the classical pathway of complement in non-lesional skin of patients with systemic lupus erythematosus. J Cutan Pathol 2005; 32: 537-540.
38. Gabrielli A, Corvetta A, Montroni M, Rupoli S, Danieli G. Immune deposits in normal skin of patients with systemic lupus erythematosus: relationship to the serum capacity to solubilize immune complexes. Clin Immunol Immunopathol 1985; 36: 266-274.
39. Dickey WD, Harley JB, Scofield RH. Human autoantibody production in the severe combined immunodeficiency (scid) mouse. Clin Exp Rheumatol 1994; 12: 157-161.
40. Chen X, Wolin SL. The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity. J Mol Med 2004; 82: 232-239.
41. Yoshimasu T, Hiroi A, Ohtani T, Uede K, Furukawa F. Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus. J Dermatol Sci 2002; 29: 35-41.
42. Smith CD, Marino C, Rothfield NF. The clinical utility of the lupus band test. Arthritis Rheum 1984; 27: 382-387.
43. Krysko DV, D'Herde K, Vandenabeele P. Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 2006; 11: 1709-1726.
44. Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241-1250.
45. Gaipl US, Kuhn A, Sheriff A, et al. Clearance of apoptotic cells in human SLE. Curr Dir Autoimmun 2006; 9: 173-187.
46. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980; 68: 251-306.
47. Fadok VA, Bratton DL, Guthrie L, Henson PM. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol 2001; 166: 6847-6854.
48. Devitt A, Parker KG, Ogden CA, et al. Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/-mice. J Cell Biol 2004; 167: 1161-1170.
49. Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RA. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol 2005; 174: 3220-3226.
50. Maruoka Y, Harada H, Mitsuyasu T, et al. Keratinocytes become terminally differentiated in a process involving programmed cell death. Biochem Biophys Res Commun 1997; 238: 886-890.
51. Haake AR, Polakowska RR. Cell death by apoptosis in epidermal biology. J Invest Dermatol 1993; 101: 107-112.
52. Seiberg M, Marthinuss J, Stenn KS. Changes in expression of apoptosis-associated genes in skin mark early catagen. J Invest Dermatol 1995; 104: 78-82.
53. Weedon D. Apoptosis. Adv Dermatol 1990; 5: 243-254.
54. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer S. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991; 88: 6961-6965.
55. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994; 145: 1323-1336.
56. David-Bajar KM, Davis BM. Pathology, immunopathology, and immunohistochemistry in cutaneous lupus erythematosus. Lupus 1997; 6: 145-157.
57. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994; 9: 1799-1805.
58. Hoffman B, Liebermann DA. Molecular controls of apoptosis: differentiation/growth arrest primary response genes, protooncogenes, and tumor suppressor genes as positive & negative modulators. Oncogene 1994; 9: 1807-1812.
59. Selvakumaran M, Lin HK, Miyashita T, et al. Immediate early upregulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene 1994; 9: 1791-1798.
60. Baima B, Sticherling M. Apoptosis in different cutaneous manifestations of lupus erythematosus. Br J Dermatol 2001; 144: 958-966.
61. Itoh N, Tsujimoto Y, Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 1993; 151: 621-627.
62. Young AR. The sunburn cell. Photodermatol 1987; 4: 127-134.
63. Enk CD, Jacob-Hirsch J, Gal H, et al. The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes. Oncogene 2006; 25: 2601-2614.
64. Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 1990; 94: 77-85.
65. Nived O, Johansen PB, Sturfelt G. Standardized ultraviolet-A exposure provokes skin reaction in systemic lupus erythematosus. Lupus 1993; 2: 247-250.
66. van Weelden H, Velthuis PJ, Baart de la Faille H. Light-induced skin lesions in lupus erythematosus: photobiological studies. Arch Dermatol Res 1989; 281: 470-474.
67. Kuhn A, Sonntag M, Richter-Hintz D, et al. Phototesting in lupus erythematosus: a 15-year experience. J Am Acad Dermatol 2001; 45: 86-95.
68. Aragane Y, Kulms D, Metze D, et al. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol 1998; 140: 171-182.
69. Wehrli P, Viard I, Bullani R, Tschopp J, French LE. Death receptors in cutaneous biology and disease. J Invest Dermatol 2000; 115: 141-148.
70. Reefman E, Limburg PC, Kallenberg CG, Bijl M. Do apoptotic cells accumulate in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation? Comment on the article by Kuhn et al. Arthritis Rheum 2066; 54: 3373-3374.
71. Reefman E, Kuiper H, Jonkman W, Limburg PC, Kallenberg CG, Bijl M. Skin sensitivity to UVB irradiation in systemic lupus erythematosus is not related to the level of apoptosis induction in keratinocytes. Rheumatology 2006; 45: 538-544.
72. Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984; 142: 67-77.
73. Negoescu A, Guillermet C, Lorimier P, Brambilla E, Labat-Moleur F. Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomed Pharmacother 1998; 52: 252-258.
74. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 1995; 21: 1465-1468.
75. Labat-Moleur F, Guillermet C, Lorimier P, et al. TUNEL apoptotic cell detection in tissue sections: critical evaluation and improvement. J Histochem. Cytochem 1998; 46: 327-334.
76. Oberhammer F, Wilson JW, Dive C, et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993; 12: 3679-3684.
77. Kerr JF, Wyllie AH, Currie A. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
78. Grishman E, Churg J. Ultrastructure of dermal lesions in systemic lupus erythematosus. Lab Invest 1970; 22: 189-197.