Suitability of a US3-inactivated HSV mutant (L1BR1) as an oncolytic virus for pancreatic cancer therapy

Cancer Gene Therapy

Volumn 14, Issue 6, 2007, Pages 533-542

  Kasuya, H ^a,c   Nishiyama, Y ^b   Nomoto, S ^a   Goshima, F ^b   Takeda, S ^a   Watanabe, I ^a   Nomura, N ^a   Shikano, T ^a   Fujii, T ^a   Kanazumi, N ^a   Nakao, A ^a  

^a Department of Surgery II ^*  (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Herpes simplex virus; L1BR1; Oncolytic virus; Pancreatic cancer; US3

Indexed keywords

CISPLATIN; FLUOROURACIL; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE LOCUS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; ONCOLYTIC VIROTHERAPY; PANCREAS CANCER; PRIORITY JOURNAL; ULTRAVIOLET RADIATION; VIRUS INFECTION; VIRUS REPLICATION; VIRUS VIRULENCE;

CISPLATIN; FLUOROURACIL; GENE THERAPY; GENETIC VECTORS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; PANCREATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; SIMPLEXVIRUS; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

HERPESVIRIDAE; MUS; REPLICATION COMPETENT VIRUSES; SIMPLEXVIRUS;

EID: 34249031842     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7701049     Document Type: Article

References (41)

1. O'Brien V. Virus and apoptosis. J Gen Virol 1998; 66: 6939-6945.
2. Teodoro JG, Branton PE. Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5. J Virol 1997; 71: 3620-3627.
3. Teodoro JG, Branton PE. Regulation of apoptosis by viral gene products. J Virol 1997; 71: 1739-1746.
4. Tschopp J, Thome M, Hofmann K, Meinl E. The fight of viruses against apoptosis. Curr Opin Genet Dev 1998; 8: 82-87.
5. Nishiyama Y, Murata T. Anti-apoptotic protein kinase of herpes simplex virus. Trends Microbiol 2002; 10: 105-107.
6. Murata T, Goshima F, Daikoku T, Takakuwa H, Nishiyama Y. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation. Genes Cells 2000; 5: 1017-1027.
7. Leopardi R, Van Sant C, Roizman B. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc Natl Acad Sci USA 1997; 94: 7891-7896.
8. Munger J, Roizman B. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins. Proc Natl Acad Sci USA 2001; 98: 10410-10415.
9. Nishiyama Y, Yamada Y, Kurachi R, Daikoku T. Construction of a US3 lacZ insertion mutant of herpes simplex virus type 2 and characterization of its phenotype in vitro and in vivo. Virology 1992; 190: 256-268.
10. Asano S, Honda T, Goshima F. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice. J Gen Virol 1999; 80: 51-56.
11. Aubert M, Blaho JA. The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells. J Virol 1999; 73: 2803-2813.
12. Galvan V, Roizman B. Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc Natl Acad Sci USA 1998; 95: 3931-3936.
13. Koyama AH, Adachi H. Induction of apoptosis by herpes simplex virus type 1. J Gen Virol 1997; 78: 2909-2912.
14. Jerome KR, Tait JF, Koelle DM, Corey L. Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis. J Virol 1998; 72: 436-441.
15. Galvan V, Bradimarti R, Roizman B. Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death. J Virol 1999; 73: 3219-3226.
16. Leopardi R, Roizman B. The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Proc Natl Acad Sci USA 1996; 93: 9583-9587.
17. Jerome KR, Fox R, Chen Z, Sears AE, Lee H, Corey L. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. J Virol 1999; 73: 8950-8957.
18. Sawada T, Ho JJL, Chung YS. Stimulation of cellular motility by factor(s) released by SW1990 pancreatic cancer cells. Gastroenterology 1993; 104: A334.
19. Aoki K, Yoshida T, Matsumoto N. Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum Gene Ther 1997; 8: 1105-1113.
20. Hosono J, Narita T, Kimura N, Sato M, Nakashio T, Kasai Y. Involvement of adhesion molecules in metastasis of SW1990, human pancreatic cancer cells. J Surg Oncol 1998; 67: 77-84.
21. Rice SA, Lam V, Knipe DM. The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function. J Virol 1993; 67: 1778-1787.
22. Carroll NM, Chiocca EA, Takahashi K, Tanabe KK. Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Ann Surg 1996; 224: 329-330.
23. Asano S, Honda T, Goshima F, Watanabe D, Miyake Y, Sugiura Y. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice. J Gen Virol 1999; 80: 51-56.
24. Koyama AH, Akari H, Adachi A. Induction of apoptosis in Hep-2 cells by infection with herpes simplex virus type 2. Arch Virol 1998; 143: 2435-2441.
25. Antoni BA, Sabbatini P, Rabson AB, White E. Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection. J Virol 1995; 69: 2384-2392.
26. Chinnaiyan AM, Woffendin C, Dixit VM, Nabel GJ. The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication. Nat Med 1997; 3: 333-337.
27. Sandstrom PA, Roberts B, Folks TM, Buttke TM. HIV gene expression enhances T cell susceptibility to hydrogen peroxide-induced apoptosis. AIDS Res Hum Retroviruses 1993; 9: 1107-1113.
28. Clem RJ, Fechheimer M, Miller LK. Protein prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 1991; 29: 1388-1390.
29. Brun A, Rivas C, Esteban M, Escribano JM, Alonso C. African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death. Virology 1996; 225: 227-230.
30. Afonso CL, Neilan JG, Kutish GF, Rock DL. An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death. J Virol 1996; 70: 4858-4863.
31. Gooding LR. Virus proteins that counteract host immune defenses. Cell 1992; 71: 5-7 Review.
32. Sauthoff H, Heitner S, Rom WN, Hay JG. Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector. Hum Gene Ther 2000; 11: 379-388.
33. Boulakia CA, Chen G, Ng FW, Teodoro JG, Branton PE, Nicholson DW. Bcl-2 and adenovirus E1B 19kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly (ADP-ribose) polymerase. Oncogene 1996; 12: 529-535.
34. Rao L, Perez D, White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 1996; 135: 1441-1455.
35. Hu MC, Hsu MT. Adenovirus E1B 19K protein is required for efficient DNA replication in U937 cells. Virology 1997; 227: 295-304.
36. Chiou SK, White E. Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection. Virology 1998; 244: 108-118.
37. Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997; 8: 37-44.
38. Yeung SN, Tufaro F. Replicating herpes simplex virus vectors for cancer gene therapy. Expert Opin Pharmacother 2000; 1: 623-631.
39. Varghese S, Rabkin SD. Oncolytic herpes simplex virus vectors for cancer virotherapy. Cancer Gene Ther 2002; 9: 967-978 Review.
40. Nakao A, Kimata H, Imai T, Kikumori T, Teshigahara O, Nagasaka T. Injection of herpes simplex virus HF10 in recurrent breast cancer. Ann Oncol 2004; 15: 988-989.
41. Takakuwa H, Goshima F, Nozawa N, Yoshikawa T, Kimata H, Nakao A. Oncolytic viral therapy using a spontaneously generated herpes simplex virus type 1 variant for disseminated peritoneal tumor in immunocompetent mice. Arch Virol 2003; 148: 813-825.