Pharmacokinetic modeling and simulation of gastrointestinal transit effects on plasma concentrations of drugs from mixed immediate-release and enteric-coated pellet formulations

Pharmaceutical Development and Technology

Volumn 12, Issue 2, 2007, Pages 193-202

  Watanalumlerd, Prapoch ^a   Christensen, J Mark ^b   Ayres, James W ^b  

^a Pharmaceutical Product Development   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Enteric coated; Gastrointestinal transit; Immediate release; Pellet; Pharmacokinetic modeling; Simulation

Indexed keywords

AMPHETAMINE; DEXAMPHETAMINE; MELATONIN;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; ENTERIC COATED TABLET; GASTROINTESTINAL TRANSIT; HUMAN; IMMEDIATE RELEASE FORMULATION; MAXIMUM PLASMA CONCENTRATION; MODEL; MONTE CARLO METHOD; PRIORITY JOURNAL; SIMULATION; STOMACH EMPTYING; SUSTAINED RELEASE FORMULATION;

AMPHETAMINES; CAPSULES; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; FOOD-DRUG INTERACTIONS; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; SOLUBILITY;

EID: 34249008163     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701212750     Document Type: Article

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