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Volumn , Issue 7, 2007, Pages 1196-1202

Archazolid-7-O-β-D-glucopyranoside - Isolation, structural elucidation and solution conformation of a novel V-ATPase inhibitor from the myxobacterium Cystobacter violaceus

Author keywords

Archazolid; Glycosides; Inhibitors; Natural products; Polyketides

Indexed keywords


EID: 34249007040     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200600912     Document Type: Article
Times cited : (26)

References (23)
  • 7
    • 0000701347 scopus 로고    scopus 로고
    • For a review on cytotoxic secondary metabolites from myxobacteria, see:, Eds, S. Grabley, R. Thierecke, Springer Verlag, Berlin
    • For a review on cytotoxic secondary metabolites from myxobacteria, see: H. Reichenbach, G. Höfle, in: Drug Discovery from Nature (Eds.: S. Grabley, R. Thierecke), Springer Verlag, Berlin, 1999, pp. 149-179.
    • (1999) Drug Discovery from Nature , pp. 149-179
    • Reichenbach, H.1    Höfle, G.2
  • 9
    • 17844369968 scopus 로고    scopus 로고
    • [7]. This subunit forms an oligomer, building up a ring structure of six or more copies, which transports protons across the membrane. In addition, Murata et al. recently described the structure of the ring from a bacterial V-ATPase at 2.1 Å resolution and showed that 10 copies form the c ring. These results make a detailed study on the 3D structure of novel inhibitors, such as the one described here, a rewarding task: T. Murata, I. Yamato, Y. Kakinuma, A. G. Leslie, J. E. Walker, Science 2005, 308, 654-659;
    • [7]. This subunit forms an oligomer, building up a ring structure of six or more copies, which transports protons across the membrane. In addition, Murata et al. recently described the structure of the ring from a bacterial V-ATPase at 2.1 Å resolution and showed that 10 copies form the c ring. These results make a detailed study on the 3D structure of novel inhibitors, such as the one described here, a rewarding task: T. Murata, I. Yamato, Y. Kakinuma, A. G. Leslie, J. E. Walker, Science 2005, 308, 654-659;
  • 14
    • 34250682171 scopus 로고    scopus 로고
    • No chemical analyses of the secondary metabolites of this myxobacterial species have previously been reported
    • No chemical analyses of the secondary metabolites of this myxobacterial species have previously been reported.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.