Different clinical manifestations of hyperammonemic encephalopathy

Epilepsy and Behavior

Volumn 10, Issue 4, 2007, Pages 583-587

  Gomceli, Y B ^a   Kutlu, G ^a   Cavdar, L ^a   Sanivar, F ^a   Inan, L E ^a  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Behavior; Encephalopathy; Hyperammonemia; Valproate

Indexed keywords

AMMONIA; CARBAMAZEPINE; CARNITINE; CLONAZEPAM; ETIRACETAM; LAMOTRIGINE; VALPROIC ACID;

ACUTE TOXICITY; ADULT; AMMONIA BLOOD LEVEL; ANTICONVULSANT THERAPY; ARTICLE; ATAXIA; ATONIC SEIZURE; BRAIN DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; COMPLEX PARTIAL SEIZURE; CONFUSION; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; FREQUENCY ANALYSIS; GRAND MAL SEIZURE; HUMAN; HYPERAMMONEMIA; MALE; MONOTHERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; SYMPTOMATOLOGY; TONIC CLONIC SEIZURE;

ADULT; ANTICONVULSANTS; BRAIN DISEASES, METABOLIC; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HUMANS; HYPERAMMONEMIA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; VALPROIC ACID;

EID: 34248664095     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2007.02.013     Document Type: Article

References (20)

1. Löscher W. Valproate: a reappraisal of its pharmacodynamic properties and mechanism of action. Prog Neurobiol 58 (1999) 31-59
2. Vossler D.G., Wilensky A.J., Chawton D.F., et al. Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy. Epilepsia 43 (2002) 154-159
3. Zaret B.S., Beckner R.R., Marini A.M., Wagle W., and Passarelli C. Sodium valproate-induced hyperammonemia without hepatic dysfunction. Neurology 32 (1982) 206-208
4. Hamer H.M., Knake S., Schomborg M.A., and Rosenow F. Valproic acid induced hyperammonemic encephalopathy in the presence of topiramate. Neurology 54 (2000) 230-232
5. Kimmel R.J., Irwin S.A., and Meyer J.M. Valproic acid-associated hyperammonemic encephalopathy: a case report from the psychiatric setting. Int Clin Psychopharmacol 20 (2005) 57-58
6. Verrotti A., Trotta D., Morgese G., and Chiarelli F. Valproate-induced hyperammonemic encephalopathy. Metab Brain Dis 17 (2002) 367-373
7. Isojarvi J.I., Pakorinan A.J., and Myllyla V.V. Thyroid function with antiepileptic drugs. Epilepsia 33 (1992) 142-148
8. Vainionpaa L.K., Mikkonen K., Rattya J., et al. Thyroid function in girls with epilepsy with carbamezepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. Epilepsia 45 (2004) 197-203
9. Stephen L.J., Kwan P., Shapiro P., Dominiczok M., and Brodie M.J. Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy. Epilepsia 22 (2001) 1002-1006
10. Blindauer K.A., Harrington G., Morris G.L., and Ho K.C. Fulminant progression of demyelinating disease after valproate-induced encephalopathy. Neurology 51 (1998) 292-295
11. Noremberg M.D. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin Liver Dis 16 (1996) 245-253
12. Rumbach L., Cremel G., Marescaux C., Warter J.M., and Waksman A. Valproate-induced hyperammonemia of renal origin. Biochem Pharmacol 38 (1989) 3963-3967
13. Mallet L., Babin S., and Morais J.A. Valproic acid induced hyperammonemia and thrombocytopenia in an elderly woman. Ann Pharmacother 38 (2004) 1643-1647
14. Marini A.M., Zaret B.S., and Beckner R.R. Hepatic and renal contributions to valproic acid-induced hyperammonemia. Neurology 38 (1988) 365-371
15. Gidal B.E., Inglese C.M., Meyer J.F., Pitterle M.E., Antonopoulos J., and Rust R.S. Diet and valproate-induced transient hyperammonemia: effect of L-carnitine. Pediatr Neurol 6 (1997) 301-305
16. Matsuda I., Ohtani Y., and Ninomiya N. Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy. J Pediatr 109 (1986) 131-133
17. Laub M.C., Paetzke-Brunner I., and Jaeger G. Serum carnitine during valproic acid therapy. Epilepsia 27 (1986) 559-562
18. Zelnik N., Fridkis I., and Gruener N. Reduced carnitine and antiepileptic drugs: cause relationship or co-existence?. Acta Pediatr 84 (1995) 93-95
19. Bohles H., Sewell A.C., and Wenzel D. The effect of carnitine supplementation in valproate-induced hyperammonemia. Acta Pediatr 85 (1996) 446-449
20. Raskind J., and El-Chaar G. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 34 (2000) 630-638