Finasteride, a 5α-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat

Hormones and Behavior

Volumn 51, Issue 5, 2007, Pages 605-610

  Verdi, Javad ^a,b   Ahmadiani, Abolhassan ^b  

^a KASHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

5 Reductase; Analgesia; Dependence; Finasteride; Morphine; Testosterone; Tolerance

Indexed keywords

FINASTERIDE; MORPHINE; NALOXONE; STEROID 5ALPHA REDUCTASE INHIBITOR; ENZYME INHIBITOR; NARCOTIC ANALGESIC AGENT; STEROID 5ALPHA REDUCTASE;

ABSTINENCE; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; MALE; MORPHINE TOLERANCE; NOCICEPTION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TAIL FLICK TEST; WITHDRAWAL SYNDROME; ADDICTION; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; DRUG INTERACTION; DRUG TOLERANCE; ENZYMOLOGY; METABOLISM; PAIN THRESHOLD; PHYSIOLOGY; WISTAR RAT;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DRUG INTERACTIONS; DRUG TOLERANCE; ENZYME INHIBITORS; FINASTERIDE; MALE; MORPHINE; PAIN THRESHOLD; RATS; RATS, WISTAR; SUBSTANCE-RELATED DISORDERS; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 34248657964     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2007.02.008     Document Type: Article

References (42)

1. Abs R., Verhelst J., Maeyaert J., Buyten J.P.V., Opspomer F., Adriaensen H., Verlooy J., Havenbergh T.V., Smet M., and Acker K.V. Endocrine consequences of long-term intrathecal administration of opioid. J. Clin. Endocrinol. Metab. 85 (2000) 2215-2222
2. Ahmadiani, A., Hanafi, A., 1996. Is morphine tolerance exerted via sex steroid? First Federation of Asian-Oceanic Neuroscience Society Congress (October 20-23), Pattaya, Thailand, FOANS congress Abstract A-050, p. 151.
3. Aloisi A.M., Caccarelli I., and Lupo C. Behavioral and hormonal effects of restraint stress and formalin test in male and female rats. Brain Res. Bull. 74 (1998) 57-62
4. Amini H., and Ahmadiani A. Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain. Pharmacol. Biochem. Behav. 74 (2002) 199-204
5. Amini H., and Ahmadiani A. In vivo evidence for an increase in 5alpha-reductase activity in the rat central nervous system following morphine exposure. Int. J. Dev. Neurosci. 975 (2005) 1-6
6. Barraclough C.A., and Sawyer C.H. Inhibition of the release of pituitary ovulating hormone in the rat by morphine. Endocrinology 57 (1985) 329-337
7. Bhargava H.N. Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administration behavior. Pharmacol. Rev. 46 (1994) 293-324
8. Celotti F., Negri-Cesi P., and Poletti A. Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization. Brain Res. Bull. 44 (1997) 365-375
9. Cicero T.J., Wilcox C.E., Bell R.D., and Meyer E.R. Acute reduction in serum testosterone levels by narcotics in the male rat: stereo-specificity, blockade by naloxone and tolerance. J. Pharmacol. Exp. Ther. 198 (1976) 340-346
10. Compagnone N.A., and Mellon S.H. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front. Neuroendocrinol. 21 1 (2000) 1-56
11. D'Amour F.E., and Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72 (1941) 74-79
12. 2+ channel during opioid tolerance and supersensitivity in rats. J. Pharmacol. Exp. Ther. 274 (1995) 1538-1544
13. Diaz A., Ruiz F., Florez J., Pazos A., and Hurle M.A. Mu-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system. J. Pharmacol. Exp. Ther. 274 (1995) 1545-1551
14. Evrard H.C., and Balthazart J. Aromatization of androgens into estrogens reduces behavioral responsiveness to a painful thermal stimulus in male Japanese quail. Horm. Behav. 45 (2004) 181-189
15. Ffrench-Mullen J.M.H., Danks P., and Spence K.T. Neurosteroid modulate calcium currents in hippocampus CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J. Neurosci. 14 (1994) 1963-1977
16. Fillingim R.B., and Ness T.J. Sex-related hormonal influences on pain and analgesic responses. Neurosci. Biobehav. Rev. 24 (2000) 485-501
17. Forman L., Tingle V., Estilow S., and Cater J. The response to analgesia testing is affected by gonadal steroids in the rat. Life Sci. 45 (1989) 447-454
18. Frye C.A., and Seliga A.M. Testosterone increase analgesia, anxiolysis, and cognitive performance of male rats. Cogn. Affect. Behav. Neurosci. 1 (2001) 371-381
19. Frye C.A., Cuevas C.A., and Kanarek R.B. Diet and estrous cycle influence pain sensitivity in rats. Pharmacol. Biochem. Behav. 45 (1993) 255-260
20. Frye C.A., Vankeuren K.R., Rao P.N., and Erskine M.S. Analgesic effects of the neurosteroid 3α-androstanediol. Brain Res. 709 (1996) 1-9
21. Gorin R.E., Crabbe J.C., Tanchuck M.A., Long S.L., and Finn D.A. Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. Alcohol. Clin. Exp. Res. 29 6 (2005) 939-948
22. Hau M., Dominguez O.A., and Evrard H.C. Testosterone reduces responsiveness to nociceptive stimuli in a wild bird. Horm. Behav. 46 (2004) 165-170
23. Herman B.H., Vocci F., and Bridge P. The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiate addiction. Neuropsychopharmacology 13 4 (1995) 269-293
24. Koob G.F., Sanna P.P., and Bloom F.E. Neuroscience of addiction. Neuron 21 3 (1998) 467-476
25. Lane-Ladd S.B., Pineda J., Boundy V.A., Pfeuffer T., Krupinski J., Aghajanian G.K., and Nestler E.J. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17 20 (1997) 7890-7901
26. Matsui D., Sakari M., Sato T., Murayama A., Takada I., Kim M., Takeyama K., and Kato S. Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain. Nucleic Acids Res. 30 (2002) 1387-1393
27. Maurice T., Phan V.L., Urani A., Kamei H., Noda Y., and Nabeshima T. Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities. Jpn. J. Pharmacol. 81 2 (1999) 125-155
28. Nayebi A.R., and Ahmadiani A. Involvement of the spinal serotonergic system in analgesia produced by castration. Pharmacol. Biochem. Behav. 64 (1999) 467-471
29. Nestler E.J., and Aghajanian G.K. Molecular and cellular basis of addiction. Science 278 5335 (1997) 58-63
30. Poletti A., Coscarella A., Negri-Cesi P., Colciago A., Celotti F., and Martini L. 5α-reductase isozymes in the central nervous system. Steroids 63 (1998) 246-251
31. Rajagopal A., Vassilopoulou-Sellin R., Palmer J.L., and Kaur A. Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy. J. Pain Symptom. Manage. 26 (2003) 1055-1061
32. Reddy D.S., and Kulkarni S.K. Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice. Eur. J. Pharmacol. 337 (1997) 19-25
33. Ren X., Noda Y., Mamiya T., Nagai T., and Nabeshima T. A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase. Behav. Brain Res. 152 2 (2004) 243-250
34. Rupprecht R., and Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci. 22 9 (1999) 410-416
35. Schulz S., and Hollt V. Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine-dependent rats in vivo. Eur. J. Neurosci. 10 3 (1998) 1196-1201
36. Spence K.T., Plata-Salaman C.R., and Ffrench-Mullen J.M.H. The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block calcium currents in acutely isolated hippocampal CA1 neurons. Life Sci. 49 (1991) 235-239
37. Suzuki T., Tsuda M., Narita M., Funada M., Mizoguchi H., and Misawa M. Diazepam pretreatment suppresses morphine withdrawal signs in the mouse. Life Sci. 58 4 (1996) 349-357
38. Torres J.M., and Ortega E. Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain. FASEB J. 17 (2003) 1428-1433
39. Uygur M.C., Arik A.I., Altug U., and Erol D. Effects of the 5α-reductase inhibitor finasteride on serum levels of gonadal, adrenal, and hypophyseal hormones study. Steroids 63 (1998) 208-213
40. Vendrell M., Tusell J.M., and Serratosa J. Effect of gamma hexachlorocyclohexane and its isomers on proto-oncogene c-fos expression in brain. Neurotoxicology 13 1 (1992) 301-308
41. Yilmaz B., Konar V., Kutlu S., Canpolat S., Gezen M.R., and Kelestimur H. Influence of chronic morphine exposure on serum, L.H., FSH, testosterone levels, and body and testicular weights in the development male rat. Arch. Androl. 43 (1999) 189-196
42. Zarrindast M.R., and Mousa-Ahmadi E. Effects of GABAergic system on naloxone-induced jumping in morphine-dependent mice. Eur. J. Pharmacol. 381 2-3 (1999) 129-133