Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease

Hepatology

Volumn 45, Issue 5, 2007, Pages 1261-1266

  Castro, Juan ^a   Amigo, Ludwig ^a   Miquel, Juan Francisco ^a   Gälman, Cecilia ^b   Crovari, Fernando ^a   Raddatz, Alejandro ^a   Zanlungo, Silvana ^a   Jajil, Roberto ^a   Rudling, Mats ^b   Nervi, Flavio ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYL 3 METHYL GLUTARYL COA SYNTHASE; 7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; BILE ACID; CD36 ANTIGEN; CHOLEST 4 EN 3 ONE; CHOLESTEROL 7ALPHA MONOOXYGENASE; HYDROXY 3 METHYLGLUTARYL COENZYME A REDUCTASE; LATHOSTEROL; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; OXIDOREDUCTASE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; BILE ACID SYNTHESIS; CHOLELITHIASIS; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID METABOLISM; FLUORESCENCE; HUMAN; LIVER; LIVER BIOPSY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; APOLIPOPROTEINS B; BILE ACIDS AND SALTS; BLOOD GLUCOSE; CARRIER PROTEINS; CHOLESTENONES; CHOLESTEROL; FATTY ACIDS; GALLSTONES; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LIPOPROTEINS, VLDL; LIVER; MIDDLE AGED; TRIGLYCERIDES;

EID: 34248647329     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21616     Document Type: Article

References (48)

1. Shaffer EA. Epidemiology and risk factots for gallstone disease: has the paradigm changed in the 21st century? Curr Gastroenterol Rep 2005;7:132-140.
2. Dowling RH. Review: pathogenesis of gallstones. Aliment Pharmacol Ther 2000;14:39-47.
3. Lee SP, Ko CW. Gallstones. In: Yamada T, Alpers DH, Laine L, Owyang C, Powell DW, eds. Textbook of Gastroenterology. Philadelphia: Lippincott, 1999; 2258-2280.
4. Bennion LJ, Grundy SM. Risk factors for the development of cholelithiasis in man. N Engl J Med 1978;299:1161-1167; 1221-1227.
5. Zanlungo S, Rigotti A, Nervi F, Hepatic cholesterol transport from plasma into bile: implications for gallstone disease. Curr Opin Lipidol 2004;15:279-286.
6. Gälman C, Miquel JF, Pérez RM, Einarsson C, Ståhle L, Marshall G, et al. Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians. Gastroenterology 2004;126:741-748.
7. Kang S, Davis RA. Cholesterol and hepatic lipoprotein assembly and sectetion. Biochim Biophys Acta 2000;1529:223-230.
8. Mason TM. The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes. Crit Rev Clin Lab Sci 1998;35:461-487.
9. Farkkila M, Miettinen TA. Lipid metabolism in bile acid malabsorption. Ann Med 1990;22:5-13.
10. Duane WC. Abnormal bile acid absorption in familial hypertriglyceridemia. J Lipid Res 1995;36:96-107.
11. Duane WC, Hartich LA, Bartman AE, Ho SB. Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia. J Lipid Res 2000;41:1384-1389.
12. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, et al. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hyper-cholesterolemic phenotype. J Clin Invest 2002;110:109-117.
13. Buchwald H, Varco RL, Matts, JP, Long JM, Fitch LL, Campbell GS, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. N Engl J Med 1990;323:946-955.
14. Grundy SM, Ahrens EH Jr., Salen G. Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism. J Lab Clin Med 1971;78:94- 121.
15. Einarsson K, Eticsson S, Ewerth S, Reihner E, Rudling M, Stahlberg D, et al. Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism. Eur J Clin Pharmacol 1991;40(Suppl 1):S53-S58.
16. Miller NE, Nestel P J. Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridemia. Lancet 1974;2:929-931.
17. Hitokane H, Nakahara M, Tachibana S, Shimizu M, Sato R. Bile acid teduces the sectetion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factot-4. J Biol Chem 2004;279:45685-45692.
18. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004;113:1408-1418.
19. Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, et al. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 1992;258:999-1001.
20. Gregg RE, Wetterau JR. The molecular basis of abetalipoproteinemia. Cutt Opin Lipidol 1994;5:81-86.
21. Gordon DA. Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprorein B lipoprotein assembly. Curr Opin Lipidol 1997;8:131-137.
22. Shelness GS, Sellers JA. Very-low-density lipoprotein assembly and secretion. Curr Opin Lipidol 2001;12:151-157.
23. Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, Nielsen LB, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 1999;103:1287-1298.
24. Amigo L, Castro J, Miquel JF, Zanlungo S, Young S, Nervi F. Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones. Gastroenterology 2006;131:1870-1878.
25. Tietge UJ, Bakillah A, Maugeais C, Tsukamoto K, Hussain M, Rader DJ. Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprorein B. J Lipid Res 1999;40:2134-2139.
26. Chung BH, Wilkinson T, Geer JC, Segrest JP. Preparative and quantitative isolation of plasma lipoproreins: rapid, single discontinous density gradient ultracenttifugation in a vertical rotor. J Lipid Res 1980:21:284-291.
27. Lund E, Sisfontes L, Reihner E, Bjorkhem I. Determination ofsetum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand J Clin Lab Invest 1989;49:165-171.
28. Pettersson L, Eriksson CG. Reversed-phase high-performance liquid chromatographic determination of 7 alpha-hydroxy-4-cholesten-3-one in human serum. J Chromatogr B Biomed Appi 1994;657:31-36.
29. Carr TP, Andersen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 1993;26:39-42.
30. Zanlungo S, Amigo L, Mendoza H, Miquel JF, Vio C, Click JM, et al. Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice. Gastroenterology 2000;119:1708-1719.
31. Letteron P, Sutton A, Mansouri A, Fromenty B, Pessayre D. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. HEPATOLOGY 2003;38:133-140.
32. Fisher EA, Pan M, Chen X, Wu X, Wang H, Jamil H, et al.The triple threat to nascent apolipoprotein B: evidence for multiple distinct degradative pathways. J Biol Chem 2001;276:27855-27863.
33. Funatsu T, Suzuki K, Goto M, Arai Y, Kakuta H, Tanaka H, et al. Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells. Atherosclerosis 2001;157:107-115.
34. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
35. Sunzel H, Martinssin A, Hood B. The lipid content of the human liver: a comparison between patients with gallstone disease and peptic ulcer disease. Metabolism 1964;13:1469-1474.
36. Einarsson K, Hellstrom K, Kallner M. Gallbladder disease in hyperlipoproteinaemia. Lancet 1975;1:484-487.
37. Attili AF, Capocaccia R, Carulli N, Festi D, Roda E, Barbara L, et al. Factots associated with gallstone disease in the MICOL experience. Multicenter Italian Study on Epidemiology of Cholelithiasis. HEPATOLOGY 1997;26:809-818.
38. Loria P, Lonardo A, Lombardini S, Carulli L, Verrone A, Ganazzi D, et al. Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors. J Gastroenterol Hepatol 2005;20:1176-1184.
39. Muhrbeck O, Wang FH, Bjorkhem I, Axelson M, Einarsson K. Circularing markers for biosynthesis of cholesterol and bile acids are not depressed in asymptomatic gallstone subjects. J Hepatol 1997;27:150-155.
40. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000;6:507-515.
41. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, et al. A regulatory cascade of nuclear receptors FXR, SHP-I, and LRH-I represses bile acid biosynthesis. Mol Cell 2000;6:517-526.
42. Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 2001;276:37735-37738.
43. Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, et al. Identification of a chemical tool for the orphan nuclear receptor FXR. J Med Chem 2000;43:2971-2974
44. Sinai CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744.
45. Gordon DA, Jamil H, Sharp D, Mullaney D, Yao Z, Gregg RE, et al. Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc Natl Acad Sci U S A 1994;91:7628-7632.
46. Cho H, Kang H, Choi S, Ju Y, Lee H, Park H. The possible role of Ca2+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes. Biol Pharm Bull 2005;28:1418-1423.
47. Cho H, Kang H, Ju Y, Lee H, Kim H, Park H. Augmentation of Ca2+-induced microsomal triglyceride transfer protein activity by glucose supply enhances hypertriglyceridemia in vivo. Biol Pharm Bull 2006;29:889-895.
48. Ginsberg HN, Zhang YL, Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 2005;36:232-240.