Amitriptyline to relieve pain in juvenile idiopathic arthritis: A pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials

Journal of Rheumatology

Volumn 34, Issue 5, 2007, Pages 1125-1132

  Huber, Adam M ^a,d   Tomlinson, George A ^b   Koren, Gideon ^b,c   Feldman, Brian M ^b,c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d IWK HEALTH CENTRE   (Canada)

Author keywords

Bayesian statistics; Juvenile idiopathic arthritis; Metaanalysis; Pain

Indexed keywords

AMITRIPTYLINE; PLACEBO;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ANALGESIA; ARTICLE; BAYES THEOREM; BLURRED VISION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIARRHEA; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MALE; NAUSEA; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROBABILITY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SEDATION; SIDE EFFECT; SORE THROAT; STATISTICAL MODEL; TREATMENT DURATION; XEROSTOMIA;

ADOLESCENT; AMITRIPTYLINE; ANALGESICS, NON-NARCOTIC; ARTHRITIS, JUVENILE RHEUMATOID; BAYES THEOREM; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; META-ANALYSIS; PAIN; PAIN MEASUREMENT; PILOT PROJECTS; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 34248642245     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Peterson LS, Mason T, Nelson A, O'Fallon WM, Gabriel SE. Juvenile rheumatoid arthritis in Rochester, Minnesota 1960-1993: Is the epidemiology changing? Arthritis Rheum 1996;39:1385-90.
2. Laaksonen A-L, Laine V. A comparative study of joint pain in adult and juvenile rheumatoid arthritis. Ann Rheum Dis 1961;20:386-7.
3. Scott PJ, Ansell BM, Huskisson EC. Measurement of pain in juvenile chronic polyarthritis. Ann Rheum Dis 1977;36:186-7.
4. Schanberg LE, Anthony KK, Gil KM, Maurin EC. Daily pain and symptoms in children with polyarticular arthritis. Arthritis Rheum 2003;48:1390-7.
5. Lovell DJ, Walco GA. Pain associated with juvenile rheumatoid arthritis. Pediatr Clin North Am 1989;36:1015-27.
6. Sherry DD, Bohnsack J, Salmonson K, Wallace CA, Mellins E. Painless juvenile rheumatoid arthritis. J Pediatr 1990;116:921-3.
7. Varni JW, Thompson KL, Hanson V, Brik R. Chronic musculoskeletal pain and functional status in juvenile rheumatoid arthritis: an empirical model. Pain 1988;32:1-7.
8. Huygen ACJ, Kuis W, Sinnema G. Psychological, behavioral and social adjustment in children and adolescents with juvenile chronic arthritis. Ann Rheum Dis 2000;59:276-82.
9. Billings AG, Moos RH, Miller JJ, Gottlieb J. Psychosocial adaptation in juvenile rheumatic disease: a controlled evaluation. Health Psychol 1987;6:345-59.
10. Doherty E, Yanni G, Conroy RM, Bresnihan B. A comparison of child and parent ratings of disability and pain in juvenile chronic arthritis. J Rheumatol 1993;21:1563-6.
11. Malleson PN, Oen K, Cabral DA, Petty RE, Rosenberg AM, Cheang M. Predictors of pain in children with established juvenile rheumatoid arthritis. Arthritis Rheum 2004;51:222-7.
12. Ilowite NT, Walco GA, Pochaczevsky R. Assessment of pain in patients with juvenile rheumatoid arthritis: relation between pain intensity and degree of joint inflammation. Ann Rheum Dis 1992;51:343-6.
13. Hagglund JH, Schopp LM, Alberts KR, Cassidy JT, Frank RG. Predicting pain among children with juvenile rheumatoid arthritis. Arthritis Care Res 1995;8:36-42.
14. Koh W, Pande I, Samuels A, Jones SD, Calin A. Low dose amitriptyline in ankylosing spondylitis: A short term, double blind, placebo controlled study. J Rheumatol 1997;24:2158-61.
15. Rani PU, Naidu MUR, Prasad VBN, Rao TR, Shobha JC. An evaluation of antidepressants in rheumatic pain conditions. Anesth Analg 1996;83:371-5.
16. Goldenberg DI, Mayskiy M, Mossey C, Ruthazer R, Schmid C. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. Arthritis Rheum 1996;39:1852-9.
17. Carette S, Bell MJ, Reynolds WJ, et al. Comparison of amitriptyline, cyclobenzaprine and placebo in the treatment of fibromyalgia. Arthritis Rheum 1994;37:32-40.
18. Godfrey RG. A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. Arch Intern Med 1996;156:1047-52.
19. Yaron I, Shirazi I, Judovich R, Levartovsky D, Caspi D, Yaron M. Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures. Arthritis Rheum 1999;42:2561-8.
20. Barlow CF. Migraine in the infant and toddler. J Child Neurol 1994;9:92-4.
21. Elser JM, Woody RC. Migraine headache in the infant and young child. Headache 1990;30:366-8.
22. Hyams JS, Hyman PE. Recurrent abdominal pain and the biopsychosocial model of medical practice. J Pediatrics 1998;133:473-8.
23. Romano TJ. Fibromyalgia in children: diagnosis and treatment. WV Med J 1991;87:112-4.
24. Edgington ES. Statistics and single case analysis. Prog Behav Modif 1984;16:83-119.
25. Kazdin AE. Single-case research designs: Methods for clinical and applied settings. New York: Oxford University Press; 1982.
26. Parsonson BS, Baer DM. The analysis and presentation of single-subject data. In: Kratochwill TR, editor. Single-subject research: Strategies for evaluating change. New York: Academic Press; 1978:101-65.
27. Barlow DH, Hersen M. Single case experimental design: Strategies for studying behavioral change. 2nd ed. New York: Pergamon Press; 1984.
28. Bobrovitz CD, Ottenbacher KJ. Comparison of visual inspection and statistical analysis of single-subject data in rehabilitation research. Am J Phys Med Rehabil 1998;77:94-102.
29. Nourbakhsh MR, Ottenbacher KJ. The statistical analysis of single-subject data: A comparative examination. Phys Ther 1994;74:768-76.
30. Guyatt G, Sackett D, Adachi J, et al. A clinician's guide to conducting randomized trials in individual patients. Can Med Assoc J 1988;139:497-503.
31. Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B. Clinical usefulness of amitriptyline in fibromyalgia: The results of 23 N-of-1 randomized controlled trials. J Rheumatol 1991;18:447-51.
32. Zucker DR, Schmid CH, Mcintosh MW, D'Agostino RB, Selker HP, Lau J. Combining single patient (n-of-1) trials to estimate population treatment effects and to evaluate individual patient response to treatment. J Clin Epidemiol 1997;50:401-10.
33. Jensen MB, McFarland CA. Increasing the reliability and validity of pain intensity measurement in chronic pain patients. Pain 1993;55:195-203.
34. Bloom BJ, Alario AJ, Nobile C, Owens JA. The association of sleep disturbance with disease activity and parent-reported pain in children with juvenile rheumatoid arthritis [abstract]. Arthritis Rheum 1998;41 Suppl:S47.
35. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989;46:1121-3.
36. Singh G, Athreya BH, Fries JF, Goldsmith DP. Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum 1994;37:1761-9.
37. Giannini EH, Ruperto N, Ravelli A, Lovell DJ, Felson DT, Martini A. A preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 1997;40:1202-9.
38. Dhanani S, Quenneville J, Perron M, Abdolell M, Feldman BM. Minimal difference in pain associated with change in quality of life in children with rheumatic disease. Arthritis Rheum 2002;47:501-5.
39. Dempster H, Porepa M, Young N, Feldman BM. The clinical meaning of functional outcome scores in children with juvenile arthritis. Arthritis Rheum 2001;44:1768-74.
40. Coxeter P, Schluter P, Eastwood H, Nikles C, Glasziou P. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomized n-of-1 trials. Complement Ther Med 2003;11:215-22.