Structure-Activity-Based Design of a Synthetic Malaria Peptide Eliciting Sporozoite Inhibitory Antibodies in a Virosomal Formulation

Chemistry and Biology

Volumn 14, Issue 5, 2007, Pages 577-587

  Okitsu, Shinji L ^a   Kienzl, Ursula ^b   Moehle, Kerstin ^b   Silvie, Olivier ^c   Peduzzi, Elisabetta ^a   Mueller, Markus S ^a   Sauerwein, Robert W ^d   Matile, Hugues ^e   Zurbriggen, Rinaldo ^f   Mazier, Dominique ^c   Robinson, John A ^b   Pluschke, Gerd ^a  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

^f Pevion Biotech Ltd   (Switzerland)

Author keywords

CHEMBIOL; MICROBES

Indexed keywords

CIRCUMSPOROZOITE PROTEIN, PROTOZOAN; MALARIA VACCINE; MONOCLONAL ANTIBODY; PHOSPHATIDYLETHANOLAMINE; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; UNCLASSIFIED DRUG; VIROSOME;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CROSS REACTION; DRUG DESIGN; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HYBRIDOMA; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; POLYACRYLAMIDE GEL ELECTROPHORESIS; RABBIT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, PROTOZOAN; CHEMISTRY, PHARMACEUTICAL; CROSS REACTIONS; DRUG DESIGN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HYBRIDOMAS; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA VACCINES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLETHANOLAMINES; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTOZOAN PROTEINS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; VIROSOMES;

MUS; ORTHOMYXOVIRIDAE; ORYCTOLAGUS CUNICULUS; PLASMODIUM FALCIPARUM;

EID: 34248598563     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2007.04.008     Document Type: Article

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