Manufacture of fine spherical granules by an extrusion/spheronization method

International Journal of Pharmaceutics

Volumn 337, Issue 1-2, 2007, Pages 56-62

  Kanbe, Hideyoshi ^a,b   Hayashi, Tetsuo ^a   Onuki, Yoichi ^a   Sonobe, Takashi ^b  

^a SSP CO LTD   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Extrusion pressure; Extrusion spheronization; Fine spherical granules; Low substituted hydroxypropylcellulose (L HPC); Pressure sensor; Swelling property

Indexed keywords

CALCIUM DERIVATIVE; CARMELLOSE CALCIUM; CROSCARMELLOSE SODIUM; DIPHENHYDRAMINE; EXCIPIENT; HYDROXYPROPYLCELLULOSE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG MANUFACTURE; FEASIBILITY STUDY; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; SPHERONIZATION;

CARBOXYMETHYLCELLULOSE; CELLULOSE; DIPHENHYDRAMINE; DRUG COMPOUNDING; EXCIPIENTS; FEASIBILITY STUDIES; PARTICLE SIZE; POWDERS; PRESSURE; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 34248596058     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.12.020     Document Type: Article

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