Cross-linking of elafin/SKALP to elastic fibers in photodamaged skin: Too much of a good thing?

Journal of Investigative Dermatology

Volumn 127, Issue 6, 2007, Pages 1286-1287

  Schalkwijk, Joost ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ELAFIN; ELASTASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

CROSS LINKING; ELASTIC FIBER; ELASTOSIS; LIGHT DAMAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SKIN DEFECT; SKIN FIBROBLAST; ULTRAVIOLET A RADIATION;

EID: 34248587494     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700691     Document Type: Note

References (11)

1. Hawk JL, Murphy GM, Holden CA (1988) The presence of neutrophils in human cutaneous ultraviolet-B inflammation. Br J Dermatol 118:27-30
2. Kramps JA, te Boekhorst AHT, Fransen JAM, Ginsel LA, Dijkman JH (1989) Antileukoprotease is associated with elastin fibers in the extracellular matrix of the human lung. An immunoelectron microscopic study. Am Rev Respir Dis 140:471-6
3. Lewis KG, Bercovitch L, Dill SW, Robinson-Bostom L (2004) Acquired disorders of elastic tissue. I. Increased elastic tissue and solar elastotic syndromes. J Am Acad Dermatol 51:1-21
4. Molhuizen HO, Alkemade HA, Zeeuwen PL, de Jongh GJ, Wieringa B, Schalkwijk J (1993) SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. J Biol Chem 268:12028-32
5. Muto J, Kuroda K, Wachi H, Hirose S, Tajima S (2007) Accumulation of elafin in actinic elastosis of sun-damaged skin: elafin binds to elastin and prevents elastolytic degradation. J Invest Dermatol 127:1358-66
6. Pfundt R, van Ruissen F, van Vlijmen IMJJ, Alkemade JAC, Zeeuwen PLJM, Jap PK et al. (1996) Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. J Clin Invest 98:1389-99
7. Schalkwijk J, Wiedow O, Hirose S (1999) The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem J 340:569-77
8. Sellheyer K (2003) Pathogenesis of solar elastosis: synthesis or degradation? J Cutan Pathol 30:123-7
9. Starcher B, Conrad M (1995) A role for neutrophil elastase in the progression of solar elastosis. Connect Tissue Res 31:133-40
10. Wiedow O, Schröder J, Gregory H, Young JA, Christophers E (1990) Elafin: an elastase specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. J Biol Chem 265:14791-5
11. Wingens M, Van Bergen BH, Hiemstra PS, Meis JF, Vlijmen-Willems IM, Zeeuwen PL et al. (1998) Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol 111:996-1002