Impact of progesterone on cytokine-stimulated nuclear factor-kappaB signaling in HeLa cells

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 20, Issue 1, 2007, Pages 23-28

  Vidaeff, Alex C ^a   Ramin, Susan M ^a   Gilstrap III, Larry C ^a   Bishop, Karen D ^a   Alcorn, Joseph L ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Inflammation; Nuclear factor kappaB; Preterm delivery; Progesterone

Indexed keywords

I KAPPA B ALPHA; I KAPPA B ALPHA ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PROGESTERONE; SYNAPTOTAGMIN I; SYNAPTOTAGMIN I ANTIBODY; UNCLASSIFIED DRUG; GESTAGEN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CYTOPLASM; DENSITOMETRY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; KRUSKAL WALLIS TEST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; DRUG EFFECT; METABOLISM; PREMATURITY;

HELA CELLS; HUMANS; INTERLEUKIN-1BETA; NF-KAPPA B; PREMATURE BIRTH; PROGESTERONE; PROGESTINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 34248575129     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.1080/14767050601128019     Document Type: Article

References (27)

1. Allport VC, Pieber D, Slater DM, Newton R, White JO, Bennett PR. Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol Hum Reprod 2001;7:581-586.
2. Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW, Mitchell MD. Cytokines, prostaglandins and parturition - a review. Placenta 2003;24:S33-46.
3. Elliott CL, Allport VC, Loudon JA, Wu GD, Bennett PR. Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells. Mol Hum Reprod 2001;7:787-790.
4. Kelly RW. Pregnancy maintenance and parturition: The role of prostaglandin in manipulating the immune and inflammatory response. Endocr Rev 1994;15:684-706.
5. Ito A, Imada K, Sato T, Kubo T, Matsushima K, Mori Y. Suppression of interleukin 8 production by progesterone in rabbit uterine cervix. Biochem J 1994;301:183-186.
6. Gu Z, Cain L, Werrbach-Perez K, Perez-Polo JR. Differential alterations of NF-kappaB to oxidative stress in primary basal forebrain cultures. Int J Devel Neurosci 2000;18:185-192.
7. Meiss PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, Hauth JC, Miodovnik M, Varner MW, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 2003;348:2379-2385.
8. da Fonseca EB, Bittar RE, Carvalho MH, Zugaib M. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomized placebo-controlled double-blind study. Am J Obstet Gynecol 2003;188:419-424.
9. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: Evolutionary conserved mediators of immune responses. Ann Rev Immunol 1998;16:225-260.
10. Urban MB, Schreck R, Baeuerle PA. NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J 1991;10:1817-1825.
11. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002;109:S81-96.
12. Tran K, Merika M, Thanos D. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 1997;17:5386-5399.
13. Begg AA, Baldwin AS Jr. The IκB proteins: Multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev 1993;7:2064-2070.
14. Alcorn JL, Mendelson CR. Trafficking of surfactant protein A in fetal rabbit lung in organ culture. Am J Physiol 1993;264:L27-35.
15. Kurokouchi K, Kambe F, Kikumori T, Sakai T, Sarkar D, Ishiguro N, Iwata H, Seo H. Effects of glucocorticoids on tumor necrosis factor α-dependent activation of nuclear factor κB and expression of the intercellular adhesion molecule 1 gene expression in osteoblast-like ROS17/2.8 cells. J Bone Miner Res 2000;15:1707-1715.
16. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 1995;270:286-290.
17. Wissink S, van Heerde EC, van der Burg B, van der Saag PT. A dual mechanism mediates repression of NF-κB activity by glucocorticoids. Mol Endocrinol 1998;12:355-363.
18. Mitchell MD, Romero RJ, Avila C, Foster JT, Edwin SS. Prostaglandin production by amnion and decidual cells in response to bacterial products. Prostaglandins Leukot Essent Fatty Acids 1991;42:167-169.
19. Romero R, Parvizi ST, Oyarzun E, Mazor M, Wu YK, Avila C, Athanassiadis AP, Mitchell MD. Amniotic fluid interleukin-1 in spontaneous labor at term. J Reprod Med 1990;35:235-238.
20. Bertelsen M, Sanfridson A. Inflammatory pathway analysis using a high content screening platform. Assay Drug Dev Technol 2005;3:261-271.
21. Bamberger CM, Else T, Bamberger AM, Beil FU, Schulte HM. Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes. J Clin Endocrinol Metab 1999;84:4055-4061.
22. Allport VC, Slater DM, Newton R, Bennett PR. NF-κB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH). Mol Hum Reprod 2000;6:561-565.
23. Pettus EH, Wright DW, Stein DG, Hoffman SW. Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Research 2005;1049:112-119.
24. Kalkhoven E, Wissink S, van der Saag PT, van der Burg B. Negative interaction between the RelA(p65) subunit of NF-κB and the progesterone receptor. J Biol Chem 1996;271:6217-6224.
25. Bergmann MW, Staples KJ, Barnes PJ, Newton R. Nuclear factor-κB does not mediate the inhibitory effects of dexamethasone on granulocyte- macrophage colony-stimulating factor expression. Immunology 2004;111:430-434.
26. Elovitz MA, Mrinalini C. Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation? Am J Obstet Gynecol 2005;193:1149-1155.
27. Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M. Bacterial lipopolysaccharide and IFN-γ induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: Role of NF-κB activation. J Immunol 2001;166:2018-2024.