Gate movements in glutamate transporters

ACS Chemical Biology

Volumn 2, Issue 3, 2007, Pages 163-166

  Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYASPARTIC ACID; ASPARTIC ACID; LITHIUM; SODIUM ION; THALLIUM; VESICULAR GLUTAMATE TRANSPORTER 1; GLUTAMATE RECEPTOR; SODIUM CHANNEL;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; ISOTOPE LABELING; MOLECULAR MECHANICS; MOLECULAR MIMICRY; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; STOICHIOMETRY; CHANNEL GATING; CHEMISTRY; METABOLISM; REVIEW;

ARCHAEA; EUKARYOTA;

ION CHANNEL GATING; PROTEIN CONFORMATION; RECEPTORS, GLUTAMATE; SODIUM CHANNELS;

EID: 34248572483     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700040e     Document Type: Article

References (15)

1. Yernool, D., Boudker, O., Jin, Y., and Gouaux, E. (2004) Structure of a glutamate transporter homologue from Pyrococcus horikoshii, Nature 431, 811-818.
2. Boudker, O., Ryan, R. M., Yernool, D., Shimamoto, K., and Gouaux, E. (2007) Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter, Nature 445, 387-393.
3. Zerangue, N., and Kavanaugh, M. P. (1996) Flux coupling in a neuronal glutamate transporter, Nature 383, 634-637.
4. +-dependent glutamate uptake, J. Neurosci. 18, 9620-9628.
5. Kanner, B. I., and Sharon, I. (1978) Active transport of L-glutamate by membrane vesicles isolated from rat brain, Biochemistry 17, 3949-3953.
6. Kanner, B. I., and Bendahan, A. (1982) Binding order of substrates to the sodium and potassium ion coupled L-glutamic acid transporter from rat brain, Biochemistry 21, 6327-6330.
7. Jardetzky, O. (1966) Simple allosteric model for membrane pumps, Nature 211, 969-670.
8. Bendahan, A., Armon, A., Madani, N., Kavanaugh, M. P., and Kanner, B. I. (2000) Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter, J. Biol. Chem. 275, 37436-37442.
9. +/Cl-dependent neurotransmitter transporters, Nature 437, 215-223.
10. Shimamoto, K., Lebrun, B., Yasuda-Kamatani, Y., Sakaitani, M., Shigeri, Y., Yumoto, N., and Nakajima, T. (1998) DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters, Mol. Pharmacol. 53, 195-201.
11. Shlaifer, I., and Kanner, B. I. (2007) Conformationally sensitive reactivity to permeant sulfhydryl reagents of cysteine residues engineered into helical hairpin 1 of the glutamate transporter GLT-1, Mol. Pharmacol. Epub ahead of print Feb 1, DOI 10.1124/ mol.106.032607.
12. Shimamoto, K., Otsubo, Y., Shigeri, Y., Yasuda-Kamatani, Y., Satoh, M., Kaneko, S., and Nakagawa, T. (2007) Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters, Mol. Pharmacol. 71, 294-302.
13. + to the glutamate-free form and cycling of the glutamate transporter EAAC1, J. Biol. Chem. 281, 10263-10272.
14. Rosental, N., Bendahan, A., and Kanner, B. I. (2006) Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter, J. Biol. Chem. 281, 27905-27915.
15. Kavanaugh, M. P., Bendahan, A., Zerangue, N., Zhang, Y., and Kanner, B. I. (1997) Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange, J. Biol. Chem. 272, 1703-1708.