Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction

Haemophilia

Volumn 13, Issue 3, 2007, Pages 328-330

  Curry, N S ^a   Misbah, S A ^b   Giangrande, P L F ^a   Keeling, David M ^a  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Haemophilia B; Inhibitors; Tolerance

Indexed keywords

ADRENALIN; BENEFLEX; BLOOD CLOTTING FACTOR 9; CHLORPHENIRAMINE; CYCLOPHOSPHAMIDE; HYDROCORTISONE; IMMUNOGLOBULIN G; OXYGEN; RECOMBINANT BLOOD CLOTTING FACTOR 9; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ANAPHYLAXIS; ARTICLE; CASE REPORT; CHILD; DESENSITIZATION; DISEASE SEVERITY; DRUG DOSE ESCALATION; FLEXION CONTRACTURE; HEMARTHROSIS; HEMOPHILIA B; HUMAN; IMMUNOLOGICAL TOLERANCE; KNEE; MALE; NEPHROTIC SYNDROME; PRIORITY JOURNAL;

ANAPHYLAXIS; ANTIBODIES; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FACTOR IX; HEMOPHILIA B; HUMANS; IMMUNE TOLERANCE; MALE; TREATMENT OUTCOME;

EID: 34248572204     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2007.01463.x     Document Type: Article

References (5)

1. Keeling D, Beavis J, Sukhu K. A simple inhibitor screen is more sensitive than a Bethesda assay in monitoring for the development of inhibitors in haemophilia A and B. Br J Haematol 2005; 128: 885.
2. Ewenstein BM, Takemoto C, Warrier I et al. Nephrotic syndrome as a complication of immune tolerance in hemophilia B (Letter). Blood 1997; 89: 1115-6.
3. Shibata H, Shima M, Misu H, Okimoto Y, Giddings JC, Yoshioka A. Management of haemophilia B inhibitor patients with anaphylactic reactions to FIX concentrates. Haemophilia 2003; 9: 269-71.
4. Barnes C, Rudzki Z, Ekert H. Induction of immune tolerance and suppression of anaphylaxis in a child with haemophilia B by simple plasmapheresis and antigen exposure. Haemophilia 2000; 6: 693-5.
5. Freiburghaus C, Berntrp E, Ekman M, Gunnarsson M, Kjellberg B-M, Nilsson IM. Tolerance induction using the Malmötreatment model 1982-1995. Haemophilia 1999; 5: 32-9.