Immunological traits have the potential to improve selection of pigs for resistance to clinical and subclinical disease

Animal Science

Volumn 82, Issue 5, 2006, Pages 596-606

  Henryon, M ^a   Heegaard, P M H ^b   Nielsen, J ^b   Berg, P ^a   Juul Madsen, H R ^a  

^a DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Disease resistance; Genetic variation; Heritability; Immunological factors; Pigs; Selection

Indexed keywords

ANIMALIA; SUIDAE;

EID: 34248563027     PISSN: 13577298     EISSN: 1748748X     Source Type: Journal    
DOI: 10.1079/ASC200671     Document Type: Article

References (29)

1. Edfors-Lilja, I., Wattrang, E., Magnusson, U. and Possum, C. 1994. Genetic variation in parameters reflecting immune competence of swine. Veterinary Immunology and Immunopathology 40: 1-16.
2. Enemark, H. L., Bille-Hansen, V., Lind, P., Heegaard, P. M. H., Vigre, H., Agrens, P. and Thamsborg, S. M. 2003. Pathogenicity of Cryptosporidium parvum - evaluation of an animal infection model. Veterinary Parasitology 113: 35-57.
3. Geyer, C. J. 1992. Practical Markov chain Monte Carlo. Statistical Science 7: 473-511.
4. Hammerberg, C. and Schurig, G. G. 1986. Characterization of monoclonal antibodies directed against swine leukocytes. Veterinary Immunology and Immunopathology 11: 107-121.
5. Henryon, M., Berg, P., Jensen, J. and Andersen, S. 2001. Genetic variation for resistance to clinical and subclinical diseases exists in growing pigs. Animal Science 73: 375-387.
6. Henryon, M., Sorensen, P., Heegaard, P. M. H., Nielsen, J., Berg, P. and Juul-Madsen, H. R. 2006. Limited evidence that baseline levels of immunological traits provide useful selection criteria for resistance to clinical and subclinical disease in pigs. Proceedings of the eighth world congress on genetics applied to livestock production In press.
7. Janeway, C. A. Jr., Travers, P., Walport, M. and Shlomchik, M. J. 2001. Immunobiology: the immune system in health and disease, fifth edition. Garland Publishing, New York.
8. Jensen, J., Mantysaari, E., Madsen, P. and Thompson, R. 1997. Residual maximum likelihood estimation of (co)variance components in multivariate mixed linear models using average information. Journal of the Indian Society of Agricultural Statistics 49: 215-236.
9. Jensen, P. T. and Christensen, K. 1981. Genetic studies on the in vitro PHA transformation of porcine lymphocytes. Veterinary Immunology and Immunopathology 2: 133-143.
10. Jorgensen, B. 1992. Group-level effects of breed and sire on diseases, and influence of diseases on performance of pigs in Danish test stations. Preventive Veterinary Medicine 14: 281-292.
11. Juul-Madsen, H. R., Dalgaard, T. S. and Afanassieff, M. 2000. Molecular characterization of major and minor MHC class I and II genes in B21-like haplotypes in chickens. Animal Genetics 31: 252-261.
12. Kaufman, J., Volk, H. and Wallny, H. J. 1995. A 'minimal essential Mhc' and an 'unrecognized Mhc': two extremes in selection for polymorphism. Immunological Reviews 143: 63-88.
13. Kaufmann, J. and Salomonsen, J. 1997. The 'minimal essential MHC' revisited: both peptide-binding and cell surface expression level of MHC molecules are polymorphisms selected by pathogens in chickens. Hereditas 127: 67-73.
14. Korsgaard, I. R., Lund, M. S., Sorensen, D., Gianola, D., Madsen, P. and Jensen, J. 2003. Multivariate Bayesian analysis of Gaussian, right censored Gaussian, ordered categorical and binary traits using Gibbs sampling. Genetics, Selection, Evolution 35: 159-183.
15. Lingaas, F. and Rønningen, K. 1991. Epidemiological and genetic studies in Norwegian pig herds. V. Estimates of heritability and phenotypic correlations of the most common diseases in Norwegian pig production. Acta Veterinaria Scandinavica 32: 115-122.
16. Lundeheim, N. 1979. Genetic analysis of respiratory diseases in pigs. Acta Agricultural Scandinavica A 29: 209-215.
17. Lundeheim, N. 1988. Health disorders and growth performance at a Swedish pig progeny testing station. Acta Agriculture Scandinavica A 38: 77-88.
18. Madsen, P. and Jensen, J. 2005. A user's guide to DMU (version 6, release 4-5). Danish Institute of Agricultural Sciences, Department of Genetics and Biotechnology, Research Center Foulum, Denmark.
19. Mallard, B. A., Wilkie, B. N., Kennedy, B. W., Gibson, J. and Quinton, M. 1998. Immune responsiveness in swine: Eight generations of selection for high and low immune response in Yorkshire pigs. In Proceedings of the sixth world congress on genetics applied to livestock production, vol. 27, pp. 257-264.
20. Mallard, B. A., Wilkie, B. N., Kennedy, B. W. and Quinton, M. 1992. Use of estimated breeding values in a selection index to breed Yorkshire pigs for high and low immune and innate resistance factors. Animal Biotechnology 3: 257-280.
21. Myers, R. H. 1989. Classical and modern regression with applications, second edition. Duxbury Press, Belmont.
22. Rothschild, M. F., Chen, H. L., Christian, L. L., Lie, W. R., Venier, L., Cooper, M., Briggs, C. and Warner, C. M. 1984a. Breed and swine lymphocyte antigen haplotype differences in agglutination titres following vaccination with B. bronchiseptica. Journal of Animal Science 59: 643-649.
23. Rothschild, M. F., Hill, H. T., Christian, L. L. and Warner, C. M. 1984b. Genetic differences in serum neutralization titres of pigs after vaccination with pseudorabies modified live-virus vaccine. American Journal of Veterinary Research 45: 1216-1218.
24. Smith, C., King, J. W. B. and Gilbert, N. 1962b. Genetic parameters of British large white bacon pigs. Animal Production A: 128-143.
25. Straw, B. E., Burgi, E. J., Hilley, H. D. and Leman, A. D. 1983. Pneumonia and atrophic rhinitis in pigs from a test station. Journal of the American Veterinary Medical Association 182: 607-611.
26. Straw, B. E., Leman, A. D. and Robinson, R. A. 1984. Pneumonia and atrophie rhinitis in pigs from a test station - a follow-up study. Journal of the American Veterinary Medical Association 185: 1544-1546.
27. Straw, B. E. and Rothschild, M. F. 1992. Genetic influences on liability to acquired disease. In Diseases of swine, seventh edition (ed. A. D. Leman, B. E. Straw, W. L. Mengeling, S. D. Allaire and D. J. Taylor), pp. 709-717. Iowa State University Press, Ames.
28. Wilkie, B. and Mallard, B. 1999. Selection for high immune response: an alternative approach to animal health maintenance? Veterinary Immunology and Immunopathology 72: 231-235.
29. Wilkie, B. and Mallard, B. 2000. Genetic aspects of health and disease resistance in pigs. In Breeding for disease resistance in farm animals, second edition (ed. F. E. Axford, S. C. Bishop, F. W. Nicholas and J. B. Owen), pp. 379-396. CAB International, Wallingford.