Development of strategies for conditional RNA interference

Journal of Gene Medicine

Volumn 9, Issue 4, 2007, Pages 287-298

  Allen, Danny ^a   Kenna, Paul F ^a   Palfi, Arpad ^a   McMahon, Helena P ^a   Millington Ward, Sophia ^a   O'Reilly, Mary ^a   Humphries, Pete ^a   Farrar, G Jane ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Gene therapy; Polymerase II promoters; Ribozymes; RNA interference

Indexed keywords

DOUBLE STRANDED RNA; ENHANCED GREEN FLUORESCENT PROTEIN; INTERFERON; RIBOZYME; RNA POLYMERASE II; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE CONSTRUCT; GENE TARGETING; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; RNA SEQUENCE; RNA TRANSCRIPTION; TISSUE SPECIFICITY;

ANIMALS; BASE SEQUENCE; CELL LINE; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; MICE, INBRED STRAINS; NUCLEIC ACID CONFORMATION; PROMOTER REGIONS (GENETICS); RNA; RNA INTERFERENCE; RNA POLYMERASE II; RNA, CATALYTIC;

MUS;

EID: 34248550771     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1018     Document Type: Article

References (27)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-811.
2. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411: 494-498.
3. Czauderna F, Fechtner M, Dames S. et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res 2003; 31: 2705-2716.
4. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296: 550-553.
5. Miyagishi M, Taira K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 2002; 20: 497-500.
6. Paul CP, Good PD, Winer I, Engelke DR. Effective expression of small interfering RNA in human cells. Nat Biotechnol 2002; 20: 505-508.
7. Sui G, Soohoo C, Affar el B, et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 2002; 99: 5515-5520.
8. Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A 2002; 99: 6047-6052.
9. Kawasaki H, Taira K. Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res 2003; 31: 700-707.
10. Paddison PJ, Caudy AA, Hannon GJ. Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A 2002; 99: 1443-1448.
11. Xia H, Mao Q, Paulson HL, Davidson BL. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002; 20: 1006-1010.
12. Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003; 21: 635-637.
13. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001; 25: 402-408.
14. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. Green mice' as a source of ubiquitous green cells. FEBS Lett 1997; 407: 313-319.
15. Pouton CW, Seymour LW. Key issues in non-viral gene delivery. Adv Drug Deliv Rev 2001; 46: 187-203.
16. Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002; 32: 107-108.
17. Wu X, Gao H, Pasupathy S, Tan PH, Ooi LL, Hui KM. Systemic administration of naked DNA with targeting specificity to mammalian kidneys. Gene Ther 2005; 12: 477-486.
18. Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999; 274: 305-315.
19. Tiscornia G, Singer O, Ikawa M, Verma IM. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A 2003; 100: 1844-1848.
20. Fritsch L, Martinez LA, Sekhri R, et al. Conditional gene knock-down by CRE-dependent short interfering RNAs. EMBO Rep 2004; 5: 178-182.
21. Tiscornia G, Tergaonkar V, Galimi F, Verma IM. CRE recombinase-inducible RNA interference mediated by lentiviral vectors. Proc Natl Acad Sci U S A 2004; 101: 7347-7351.
22. Ventura A, Meissner A, Dillon CP, et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A 2004; 101: 10380-10385.
23. Coumoul X, Shukla V, Li C, Wang RH, Deng CX. Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 2005; 33: e102.
24. Szulc J, Wiznerowicz M, Sauvain MO, Trono D, Aebischer P. A versatile tool for conditional gene expression and knockdown. Nat Methods 2006; 3: 109-116.
25. Hamdorf M, Muckenfuss H, Tschulena U, et al. An inducible T7 RNA polymerase-dependent plasmid system. Mol Biotechnol 2006; 33: 13-21.
26. Dickins RA, Hemann MT Zilfou JT, et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet. 2005; 37(11): 1289-1295Oct 2.
27. Zeng Y, Cai X, Cullen BR. Use of RNA polymerase II to transcribe artificial microRNAs. Methods Enzymol 2005; 392: 371-380.