Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties

Acta Pharmaceutica

Volumn 57, Issue 2, 2007, Pages 173-184

  Gupta, Venkadari Rammohan ^a   Mutalik, Srinivas ^b   Patel, Madhobhai M ^c   Jani, Girish K ^d  

^a NET Pharmacy College   (India)

^b MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^c Patan Hospital   (India)

^d L M COLLEGE OF PHARMACY   (India)

Author keywords

Celecoxib; Dissolution rate; Micromeritic properties; Solubility; Spherical crystallization

Indexed keywords

ACETONE; CELECOXIB; CHLOROFORM; POVIDONE; SOLVENT; WATER;

ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 34248547929     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-007-0014-8     Document Type: Article

References (20)

1. R. F. Shangraw, Compressed Tablets by Direct Compression, in Pharmaceutical Dosage Forms: Tablets (Eds. H. A. Lieberman, L. Lachman and J. B. Schwartz), Vol. 1, Marcel Dekker, New York 1989, pp. 195-246.
2. P. K. Kulkarni and B. G. Nagavi, Spherical crystallization, Indian J. Pharm. Ed. 36 (2002) 66-71.
3. A. R. Paradkar, A. P. Pawar, K. R. Mahadik and S. S. Kadam, Spherical crystallization: A novel particle design technique, Indian Drugs 31 (1998) 229-233.
4. Martindale The Extra Pharmacopoeia, 32nd ed., The Pharmaceutical Press, London 1999, pp. 2-12.
5. G. V. M. M. Babu, V. G. Shankar, K. H. Sankar, A. Seshasayana, N. K. Kumar and K. V. R. Murthy, Development of dissolution medium for a poorly water soluble drug, celecoxib, Indian J. Pharm. Sci. 6 (2002) 588-590.
6. M. S. Nagarsenker and M. S. Joshi, Celecoxib-cyclodextrin systems: Characterization and evaluation of in vitro and in vivo advantages, Drug Dev. Ind. Pharm. 31 (2005) 169-178.
7. P. H. Pawar, A. P. Pawar, K. R. Mahadik and A. R. Paradkar, Evalution of tableting properties of agglomerates obtained by spherical crystallisation of trimethoprim, Indian J. Pharm. Sci. 60 (1998) 24-28.
8. M. C. Deshpande, K. R. Mahadik, A. P. Pawar and A. R. Paradkar, Evaluation of spherical crystallization as a particle size enlargement technique for aspirin, Indian J. Pharm. Sci. 59 (1997) 32-34.
9. A. Sano and Y. Kawashima, Particle design of tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: improvement of dissolution rate, J. Pharm. Sci. 76 (1987) 471-474.
10. A. Sano, T. Kuriki, Y. Kawashima, H. Takenchi, T. Hino and T. Niwa, Particle design of tolbutamide by the spherical crystallization technique. III. Micromeritic properties and dissolution rate of tolbutamide spherical agglomerates prepared by the quasi-emulsion solvent diffusion method and the solvent change method, Chem. Pharm. Bull. 38 (1990) 733-739.
11. A. R. Paradkar, A. P. Pawar, J. K. Chordiya, V. B. Patil and A. R. Ketkar, Spherical crystallization of celecoxib, Drug Dev. Ind. Pharm. 28 (2002) 1213-1220.
12. th ed., Lippincott Williams and Wilkins, Baltimore 2002, pp. 423-452.
13. nd ed. (Ed. M. E. Aulton), Churchill Livingstone, London 2002, pp. 113-138.
14. Y. Kawashima, M. Okumura and H. Takenaka, Spherical crystallization. Direct spherical agglomeration of salicylic acid crystals during crystallization, Science 216 (1982) 1127-1128.
15. M. K. Chourasia, N. K. Jain, S. Jasin, N. K. Jain and S. K. Jain, Preparation and characterization of agglomerates of flurbiprofen by spherical crystallization technique, Indian J. Pharm. Sci. 3 (2003) 287-290.
16. P. DiMartino, C. Barthelemy, F. Piva, E. Joiris, G. F. Palmieri and S. Martelli, Improved dissolution behavior of fenbufen by spherical crystallization, Drug Dev. Ind. Pharm. 25 (1999) 1073-1081.
17. S. Kawashima, T. Handa, H. Takenchi, M. Okumura, H. Katou and O. Nagai, Crystal modification of phenytoin with polyethylene glycol for improving mechanical strength, dissolution rate and bio-availability by a spherical crystallization technique, Chem. Pharm. Bull. 34 (1986) 3376-3383.
18. A. Kapoor, D. K. Mujumdar and M. R. Yadav, Crystal forms of nimesulide - a sulfonanilide (non-steroidal anti-inflammatory drug), Indian J. Chem. B. 37 (1998) 572-575.
19. S. Mutalik, M. Venkatesh and N. Udupa, Fast analgesic activity from crystallized nimesulide and its solid dispersion, Indian J. Physiol. Pharmacol. 1 (2002) 115-118.
20. S. Mutalik and N. Udupa, Pharmacological evaluation of membrane moderated transdermal system of glipizide, Clin. Exp. Pharmacol. Physiol. 1-2 (2006) 17-26.