The spasmogenic and spasmolytic activities of Lavandula stoechas are mediated through muscarinic receptor stimulation and calcium channel blockade

International Journal of Pharmacology

Volumn 3, Issue 1, 2007, Pages 61-67

  Jabeen, Qaiser ^a,b   Aziz, Nauman ^b   Afzal, Zeeshan ^a,c   Gilani, Anwarul Hassan ^b  

^a THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^b AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^c UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Calcium antagonist; Lavandula stoechas; Muscarinic stimulation; Spasmogenic; Spasmolytic

Indexed keywords

ATROPINE; CALCIUM CHANNEL BLOCKING AGENT; LAVANDULA STOECHAS EXTRACT; MUSCARINIC RECEPTOR; PETROLEUM; PLANT EXTRACT; POTASSIUM ION; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CHOLINERGIC STIMULATION; CONCENTRATION RESPONSE; CONSTIPATION; CONTROLLED STUDY; DRUG ISOLATION; FRACTIONATION; GUINEA PIG; ILEUM; IN VITRO STUDY; INTESTINAL SPASM; INTESTINE CONTRACTION; JEJUNUM; LAVENDER; NONHUMAN; RABBIT; SMOOTH MUSCLE RELAXATION; SPASMOLYSIS;

EID: 34248400395     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2007.61.67     Document Type: Article

References (33)

1. Adelstein, R.S. and E. Eisenberg, 1980. Regulation and kinetics of the actin-myosin- ATP interaction. Ann. Rev. Biochem., 49: 921-956.
2. Arunlakhshana, O. and H.O. Schild, 1959. Some quantitative uses of drug antagonists. Br. J. Pharmacol., 14: 48-58.
3. Bashir, S., K.H. Janbaz, Q. Jabeen and A.H. Gilani, 2006. Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers. Phytother. Res., 20: 906-910.
4. Bolton, T.B., 1979. Mechanism of action of transmitters and other substances on smooth muscles. Physiol. Rev., 59: 606-718.
5. Brown, J.H. and P. Taylor, 1996. Muscarinic Receptor Agonists and Antagonists. In: Goodman and Gillman's: The Pharmacological Basis of Therapeutics. 9th Edn., Gilman and A.G., J.G. Hardman, L.E. Limbird, P.B. Molinoff and R.W. Ruddon, McGraw-Hill, New York, pp: 141-159.
6. Brown, J.H. and P. Taylor, 2001. Muscarinic Receptor Agonists and Antagonists. In: Goodman and Gillman's: The Pharmacological Basis of Therapeutics. 9th Edn., Gilman, A.G., J.G. Hardman, L.E. Limbird, P.B. Molinoff and R.W. Ruddon (Eds.), McGraw-Hill, New York, pp: 155-176.
7. Chiu, A.T., D.E. McCall and P. Timmermans, 1986. Pharmacological characteristics of receptor-operated and potential-operated calcium channels in rat aorta. Eur. J. Pharmacol., 127: 1-8.
8. Evans, W.C., 1996. Pharmacognosy. 14th Edn. W.B. Saunders Company Ltd., London.
9. 2+ antagonists. Gen. Pharmacol., 22: 177-181.
10. ++ in myocardium, cardiac pace makers and vascular smooth muscle. Ann. Rev. Pharmacol. Toxicol., 17: 149-166.
11. Gilani, A.H., N. Aziz, M.A. Khan, F. Shaheen, Q. Jabeen, B.S. Siddiqui and J.W. Herzig, 2000. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas. J. Ethnopharmacol., 71: 161-167.
12. Gilani, A.H. and Attau-Rehman, 2005. Trends in ethnopharmacology. J. Ethnopharmacol., 100: 43-49.
13. Gilani, A.H., M.N. Ghayur, P.J. Houghton, Q. Jabeen, S.F. Kazim, M.I. Jumani and S.A. Saeed, 2006. Studies on the hypotensive, cardio-suppressant, vasodilator and antiplatelet activities of betel nut crude cxtract and its constituents. Int. J. Pharmacol., 2: 33-41.
14. Gilani, A.H., S. Bashir, K.H. Janbaz and A.J. Shah, 2005a. Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea. J. Ethnopharmacol., 102: 289-294.
15. Gilani, A.H., A.J. Shah, M.N. Ghayur and K. Majeed, 2005b. Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci., 76: 3089-3105.
16. Hamilton, T.C., S.W. Weir and A.H. Weston, 1986. Comparison of the effect of BRL 34915 and verapamil on electrical and mechanical activity on rat portal vein. Br. J. Pharmacol., 88: 103-111.
17. Izzo, A.A., R. Capasso, F. Senatore, S. Seccia and P. Morrica, 1996. Spasmolytic activity of medicinal plants used for the treatment of disorders involving smooth muscles. Phytother. Res., 10: S107-108.
18. Kokkalou, E., 1988. The constituents of the essential oil from Lavandula stoechas growing wild in Greece. Planta Medica, 54: 58-59.
19. Lis-Balchin, M., S. Hart and S.G. Deans, 1996. Comparison of the pharmacological and antimicrobial action of commercial plant essential oils. J. Herbs Spices Med. Plant, 4: 69-86.
20. Loutzenhiser, R., P. Leyten, K. Saida and C. Van Breeman. 1985. Calcium Compartments and Mobilization During Contraction of Smooth Muscles. In: Calcium and Contractility. Humana, Cliften, New Jersey, pp: 61-92.
21. Manzoor-I-Khuda, M. and M.A. Khan, 1969. Isolation of New Compounds from Lavandula stoechas. In: Hamdard Pharmacopoeia. M. Sajid, Hamdard National Foundation, Karachi, pp: 480-482.
22. Nadkarni, A.K., 1976. Indian Materia Medica Popular Prakshan, Bombay, pp: 381-383, 474-477.
23. Plant, O.H., 1920. The effect of carminative volatile oils on the muscular movements of the intestine. J. Pharm. Exp. Ther., 16: 311-325.
24. Plant, O.H. and G.H. Miller, 1926. Effects of carminative volatile oils on the muscular activity of the stomach and colon. J. Pharm. Exp. Ther., 27: 149-164.
25. Sharif, N.A., S.X. Xu and J.M. Yanni, 1994. Histamine receptor-subtype affinities, selectivities and potencies of emedastine, a novel H1-selective antagonist and other ocularly employed antihistamines. Drug Dev. Res., 33, 448-453.
26. Sharma, S.D., M. K. Bhan, M.K. Kaul and P.L. Dhar, 1983. Morphological and oil content variation in Lavender introduced in Kashmir. Indian Perfum., 27: 28-31.
27. Taqvi, S.I.H., M.T. Aftab, M.N. Ghayur, A.H. Gilani and Z.S. Saify, 2006. Synthesis and pharmacological screening of 1-(2′, b s4′-dimethoxyphenacyl)-4-hydroxy-4-phenylpiperidinium bromide. Int. J. Pharmacol., 2: 146-151.
28. Ulubelen, A., N. Goren and Y. Olcay. 1988. Longipinene derivatives from Lavandula stoechas. Phytochemistry, 27: 3966-3967.
29. Ulubelen, A. and Y. Olcay, 1989. Triterpenoids from Lavandula stoechas. Fitoterapia, 60: 475-476.
30. Usmanghani, K., A. Saeed and M.T. Alam, 1997. Indusyunic Medicine: Traditional Medicine of Herbal, Animal and Mineral Origin in Pakistan. BCC and T. Press, University of Karachi, Karachi, pp: 184-185, 218-219.
31. + interactions in mammalian smooth muscle. Pharmacol. Rev., 30: 167-208.
32. Van-Rossum, J.M., 1963. Cumulative dose-response curves II. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch. Pharmacodyn. Therapie., 143: 299-330.
33. Williamson, E.M., D.T. Okpako and F.J. Evans, 1998. Preparation of Plant Material. In: Pharmacological Methods in Phytotherapy Research. John Wiley and Sons, London, pp: 15-23.