Systemic alendronate prevents resorption of necrotic bone duringrevascularization. A bone chamber study in rats

BMC Musculoskeletal Disorders

Volumn 3, Issue , 2002, Pages 1-5

  Åstrand, Jörgen ^a   Aspenberg, Per ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVASCULAR NECROSIS; BONE ALLOGRAFT; BONE GRAFT; BONE GROWTH; BONE SCREW; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; MALE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; RAT; REVASCULARIZATION; SYSTEMIC THERAPY; TIBIA;

EID: 34248400391     PISSN: 14712474     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-3-19     Document Type: Article

References (11)

1. Gardeniers JWM: Behaviour of normal, avascular and revascularizing cancellous bone. Nijmegen: Catholic University of Nijmegen; Monography. 1988
2. Parks NL, Engh GA: The Ranawat Award. Histology of nine structural bone grafts used in total knee arthroplasty. Clin Orthop 1997, 17-23
3. Glimcher MJ, Kenzora JE: The biology of osteonecrosis of the human femoral head and its clinical implications. III. Discussion of the etiology and genesis of the pathological sequelae; commments on treatment. Clin Orthop 1979, 273-312
4. Quinn JM, Sabokbar A, Athanasou NA: Cells of the mononuclear phagocyte series differentiate into osteoclastic lacunar bone resorbing cells. J Pathol 1996, 179:106-111
5. Wang JS, Aspenberg P: Basic fibroblast growth factor and bone induction in rats. Acta Orthop Scand 1993, 64:557-561
6. Wang JS, Aspenberg P: Basic fibroblast growth factor promotes bone ingrowth in porous hydroxyapatite. Clin Orthop 1996, 252-260
7. Aspenberg P, Astrand J: Bone Allografts Pretreated with a Bisphosphonate Do Not Resorb. Acta Orthop Scand 2002, 73:20-23
8. Agarwala S, Sule A, Pai BU, Joshi VR: Alendronate in the treatment of avascular necrosis of the hip. Rheumatology (Oxford) 2002, 41:346-347
9. Thoren K, Aspenberg P: Increased bone ingrowth distance into lipid-extracted bank bone at 6 weeks. A titanium chamber study in allogeneic and syngeneic rats. Arch Orthop Trauma Surg 1995, 114:167-171
10. Reinholz GG, Getz B, Pederson L, Sanders ES, Subramaniam M, Ingle JN, Spelsberg TC: Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts. Cancer Res 2000, 60:6001-6007
11. Bobyn D, Hacking A, Tanzer M, Richards C, Harvey E, Little D: Marked enhancment of bone growth into porous implants by zoledronic acid. In: 48th Annual Meeting of the Orthopaedic Research Society 2002, paper 0027