Novel hemoglobin (Hb Grey Lynn) substitution (α91Leu→Phe) affects heme interactions and α1β2 contacts [2]

Clinical Chemistry

Volumn 53, Issue 5, 2007, Pages 990-991

  Brennan, Stephen O ^a,b   Chan, Tim ^a   Sheen, Campbell ^b  

^a CANTERBURY HEALTH LABORATORIES   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; HEMOGLOBIN;

ADULT; BETA THALASSEMIA; BLOOD CELL COUNT; CASE REPORT; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LETTER; SICKLE CELL ANEMIA;

ADULT; CRYSTALLOGRAPHY, X-RAY; FEMALE; HEME; HEMOGLOBINS, ABNORMAL; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN SUBUNITS; THALASSEMIA;

EID: 34248377680     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.084939     Document Type: Letter

References (5)

1. Brennan SO, Mathews JRD. Hb Auckland (α87 His→Asn): A new mutation of the proximal histidine identified by electrospray mass spectrometry. Hemoglobin 1997;21:393-403.
2. Chui DHK, Fucharoen S, Chan V. Haemoglobin H disease: not necessarily a benign disorder. Blood 2003;101:791-800.
3. Gelin BR, Karplus M. Mechanism of tertiary structural change in haemoglobin. Proc Natl Acad Sci U S A 1977;74:801-5.
4. Moo-Penn WF, Johnson MH, Bechtel KC, Jue DL, Therrell BL, Schmidt RM. Hemoglobins Austin and Waco: Two hemoglobins with substitutions in the α1β2 contact region. Arch Biochem Biophys 1977;179:86-94.
5. Brennan SO, Tauro GP, Melrose W, Carrell RW. Haemoglobin Port Phillips α91 (FG3) Leu→Pro. A new unstable haemoglobin. FEBS Lett 1977; 81:115-7.