Immunohistochemical demonstration of advanced glycation end products and the effects of advanced glycation end products in ossified ligament tissues in vitro

Spine

Volumn 32, Issue 11, 2007, Pages

  Yokosuka, Kimiaki ^a   Park, Jin Soo ^a   Jimbo, Kotaro ^a   Yoshida, Tatuhiro ^a   Yamada, Kei ^a   Sato, Kimiaki ^a   Takeuchi, Masayoshi ^b   Yamagishi, Sho Ichi ^a   Nagata, Kensei ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

Author keywords

Advanced glycation end product receptor; Advanced glycation end products; Bone morphogenetic protein; Cbfa1; Glucose intolerance; Ossification of posterior longitudinal ligament; Osteocalcin; Yellow ligament

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; MESSENGER RNA; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; TRANSCRIPTION FACTOR RUNX1;

ADULT; AGED; ARTICLE; BIOACCUMULATION; CERVICAL SPINE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIGAMENT CALCINOSIS; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

AGED; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CERVICAL VERTEBRAE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IMMUNOHISTOCHEMISTRY; LIGAMENTS; MALE; MIDDLE AGED; OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT; OSTEOCALCIN; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THORACIC VERTEBRAE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 34248355958     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000263417.17526.35     Document Type: Article

References (15)

1. Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging 1996;9:69-77.
2. DeGroot J. The AGE of the matrix: Chemistry, consequence and cure. Curr Opin Pharmacol 2004;4:301-5.
3. Yamagishi S, Fujimori H, Yonekura H, et al. Advanced glycation endproducts accelerate calcification in microvascular pericytes. Biochem Biophys Res Commun 1999;258:353-7.
4. Kume S, Kato S, Yamagishi S, et al. Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J Bone Miner Res 2005;20:1647-58.
5. Loeser RF, Yammani RR, Carlson CS, et al. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum 2005;52:2376-85.
6. Yokosuka K, Park JS, Jimbo K, et al. Advanced glycation end-products downregulating intervertebral disc cell production of proteoglycans in vitro. J Neurosurg Spine 2006;5:324-9.
7. Jimbo K, Park JS, Yokosuka K, et al. Positive feedback loop of interleukin-1beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro. J Neurosurg Spine 2005;2:589-95.
8. Kanazawa T, Soejima T, Murakami H, et al. An immunohistological study of the integration at the bone-tendon interface after reconstruction of the anterior cruciate ligament in rabbits. J Bone Joint Surg Br 2006;88:682-7.
9. Takeuchi M, Yamagishi S. TAGE (toxic AGEs) hypothesis in various chronic diseases. Med Hypotheses 2004;63:449-52.
10. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-8.
11. Iwasaki K, Furukawa KI, Tanno M, et al. Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 2004;74:448-57.
12. Shingyouchi Y, Nagahama A, Niida M. Ligamentous ossification of the cervical spine in the late middle-aged Japanese men. Its relation to body mass index and glucose metabolism. Spine 1996;21:2474-8.
13. Song J, Mizuno J, Hashizume Y, et al. Immunohistochemistry of symptomatic hypertrophy of the posterior longitudinal ligament with special reference to ligamentous ossification. Spinal Cord 2006;44:576-81.
14. Kon T, Yamazaki M, Tagawa M, et al. Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 1997;60:291-6.
15. Yonemori K, Imamura T, Ishidou Y, et al. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol 1997;150:1335-47.