Defective retrotranslocation causes loss of anti-bax function in human familial prion protein mutants

Journal of Neuroscience

Volumn 27, Issue 19, 2007, Pages 5081-5091

  Jodoin, Julie ^a,b   Laroche Pierre, Stéphanie ^a,b   Goodyer, Cynthia G ^b   LeBlanc, Andréa C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Bax; Cytosolic PrP; Familial prion protein mutations; Prion protein; Retrotranslocation

Indexed keywords

PRION PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEINASE K;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; HUMAN; HUMAN CELL; MUTATION; NERVE CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASM; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; MUTATION; PRION DISEASES; PRIONS; PROTEIN FOLDING; PROTEIN TRANSPORT; TRANSFECTION;

EID: 34248351522     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0957-07.2007     Document Type: Article

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