Antidiabetic and hypolipidaemic effects of ethanolic root extract of Setaria megaphylla

International Journal of Pharmacology

Volumn 3, Issue 1, 2007, Pages 91-95

  Okokon, J E ^a   Bassey, A L ^a   Nwidu, L L ^b  

^a NIGER DELTA UNIVERSITY   (Nigeria)

^b UNIVERSITY OF UYO   (Nigeria)

Author keywords

Alloxan; Antidiabetic; Hypolipidaemic; Setaria megaphylla

Indexed keywords

ALCOHOL; ALLOXAN; GLIBENCLAMIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; SETARIA MEGAPHYLLA EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSAGE FORM COMPARISON; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; LD 50; MALE; MEDICINAL PLANT; NONHUMAN; PLANT ROOT; RAT; SETARIA MEGAPHYLLA; SINGLE DRUG DOSE; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 34248341793     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2007.91.95     Document Type: Article

References (32)

1. Balkau, B., M.A. Charles and E. Eschwege, 2000. Discussion epidemiologique des nouveaux criteres du diabete. Mt Endocrinologie, 2: 229-234.
2. Clarkson, C., V.J. Maharaj, N.R. Crouch, O.M. Grace, P. Pillay, M.G. Matsabisa, N. Bhagwandin, P.J. Smith and P.I. Folb, 2004. In vitro antiplasmodial activity of Medicinal Plants native to or naturalised in South Africa. J. Ethnopharm, 92: 177-191.
3. Djrolo, F., H. Houngbe, G. Avode, G.B. Addra, N. Kodjoh, M. Avinadje and B. Monterio, 1998. Le diabete lie a la mal nutrition (Diabete tropical). Med. Afrique Noire., 45: 538-542.
4. Edduoks, M., H. Jouad, M. Maghrani, A. Lemhadri and R. Burcelin, 2003. Inhibition of endogenous glucose productionaccounts for hypoglycaemie effects of Spergularia purpurea in streptozotocin mice. Phytomedicine, 10: 544-599.
5. Evans, W.C., 1987. Textbook of Pharmacognosy. 13th Edn., Bailliere tindall, London, pp: 342-383.
6. Friedewald, W.T., R.T. Levy and D.S. Frederickson, 1972. Estimation of the concentration of low lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin. Chem., 18: 499-502.
7. Harbone, J.B., 1983. Phytochemieal Methods. A Guide to Modern Techniques of Plant Analysis. Chapman and Hall, New York.
8. Hikino, H., M. Kobayashi, T. Suzuki and C. Konno, 1989. Mechanism of hypoglycaemic activity of aconitan. A α glycan from Acanitum carnichdi roots. J. Ethnopharmcol., 25: 295-304.
9. Hu, X., J. Sato, Y. Oshida, M. Xu, G. Bajotto and Y. Sato, 2003. Effect of Goshajinki-Gan (Chinese herbal medicine: Niu-che-sen-Qi-wan) on insulin resistance in streptozotocin induced diabetic rats. Diabetes Res. Clin. Prac., 59: 103-111.
10. Igarasi, K. and M. Ohmuma, 1995. Effect of rhamnetin and quercetin on concentration of cholesterol and lipoperoxidase in the serum and liver and the blood and liver antioxidative enzyme activities of rats. Biosci. Bio. Biochem., 59: 595-601.
11. Ivorra, M.D., M. Pay and S.A. Villar, 1989. A review of natural products and plants as potential antidiabetic agents. J. Ethnopharmacol., 27: 243-275.
12. Kaplan, N.M., 1989. The deadly quarter; upper body weight, glucose intolerance hypertriglyceridemia and hypertension. Acta. Int. Med., 149: 1514-1515.
13. Karawya, M.S. and S.A. Wahab, 1984. Diphenylamine, an antihyperglycaemic agent from onion and tea. J. Nat. Prod., 47: 775-780.
14. Khanna, P. and S.C. Jain, 1981. Hypoglycaemic activity of polypeptide-P from a plant source. J. Nat. Product., 44: 648-655.
15. Krishnakumar, K., K.T. Augustti and P.L. Vijayammal, 2000. Hypolipidaemic effect of Salacia oblonga Wall. Root bark in streptozotocin diabetic rats. Med. Sci., 28: 65-67.
16. Kumar, G.P., P. Arulsevan, D.S. Kumar and S.P. Subramanian, 2006. Antidiabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. J. Health Sci., 52: 283-291.
17. Lowe, J., 1989. The flora of Nigeria Grasses. 2nd Edn., Ibadan University Press. Ibadan, Nigeria.
18. Lorke, D., 1983. A new approach to practical acute toxicity testing. Arch. Toxicol., 54: 275-287.
19. Mironova, M.A., R.L. Klein, G.T. Virella and M.F. Lopes-Virella, 2000. Antimodified LDL antibodies, LDL-containing immune complexes and susceptibility of LDL to in vitro oxidation in patients with type-2 diabetes. Diabetes, 49: 1033-1049.
20. Nabel, E.G., 2003. Cardiovascular disease. New England J. Med., 349: 60-72.
21. Nagappa, A.N., P.A. Thakurdesai, N. Venkat Rao and J. Singh, 2003. Antidiabetic activity of T. catappa Linn. Fruits. J. Ethnopharmacol., 91: 109-113.
22. Okokon, J.E. and B.S. Antia, 2005. Hypoglycaemic and antidiabetic activity of ethanolic leaf extract of Setaria megaphylla on normal and alloxan diabetic rats. J. Natural Remedies (In Press).
23. Pari, L. and S. Amarnath, 2004. Antidiabetic activity of Boerhavia diffusa L. effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91: 109-113.
24. Reher, G., M. Slijepcevic and L. Krans, 1991. Hypoglycaemic activity of triterpenes and tannins from S. spinosum and two S. species. Planta. Med., 57: A57-A58.
25. Shimizu, M., T. Ito, S. Terashima, T. Mayashi, M. Arisawa, N. Morita, S. Kurokowa, K. Ito and Y. Hasimato, 1984. Inhibition of lens aldolse reductase by flavonoids. Phytochemistry, 23: 1885-1888.
26. The WHO expert committee on Diabetes mellitus., Tech. Rep. Series No. 646. World Health Organisation, Geneva, 1980.
27. Tomoda, M., K. Shimada, C. Konnon and H. Hikino, 1985. Structure of Panaxan B, A hypoglycaemic glycan of Panax ginseng roots. Phytochemistry, 24: 2431-2433.
28. Van Oudtshoorn, F.P., 1999. Guide to Grasses of South Africa. Briza Publications. Cape Town, pp: 56-58.
29. Yallow, R.S., H. Black, M. Villazan and S.A. Berson, 1960. Comparison of plasma insulin levels following administration of tolbutamide and glucose. Diabetes, 9: 356-362.
30. Yanardag, P. and H. Colak, 1998. Effect of Chard (Beta vulgaris L. Varcida) on blood glucose levels in Normal and alloxan induced diabetic rabbits. Pharm. Pharmacol. Comm., 4: 309-311.
31. Youn, J.Y., H.Y. Park and K.H. Cho, 2004. Antihyperglycaemic activity of Comelina communis L: Inhibition of alpha glucosidase. Diabetes Res. Clin. Practice, 66: S149-S155.
32. Zimmet, P., 2000. Globalization, Coca-Colonization and chronic disease epidemic: Can the doomday scenario be averted? J. Med., 247: 301-310.