Sex steroids do not affect shigatoxin cytotoxicity on human renal tubularor glomerular cells

BMC Nephrology

Volumn 3, Issue , 2002, Pages 1-7

  Hughes, Alisa K ^a   Schmid, Douglas I ^a   Kohan, Donald E ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PROGESTERONE; RECEPTOR; SEX HORMONE; TESTOSTERONE; VEROTOXIN; GB3 ANTIGEN; TUMOR ANTIGEN; VEROTOXIN 1;

ARTICLE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; GLOMERULUS; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INCUBATION TIME; KIDNEY CELL; KIDNEY CELL CULTURE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LD 50; NEPHROTOXICITY; PROTEIN EXPRESSION; SEXUAL MATURATION; TIME; TOXICITY TESTING; CELL CULTURE; CYTOLOGY; DRUG EFFECT; KIDNEY TUBULE; METABOLISM; PHYSIOLOGY;

ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; CELLS, CULTURED; ESTRADIOL; GONADAL STEROID HORMONES; HUMANS; KIDNEY GLOMERULUS; KIDNEY TUBULES; PROGESTERONE; SHIGA TOXIN 1; TESTOSTERONE; TOXICITY TESTS;

EID: 34248335023     PISSN: 14712369     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-3-6     Document Type: Article

References (16)

1. Siegler R, Pavia A, Christofferson R, Milligan M: A 20-year population-based study of postdiarrheal hemolytic uremic syndrome in Utah. Pediatrics 1994, 94:35-40
2. Cummings K, Mohle-Boetani J, Werner S, Vugia D: Population-based trends in pediatric hemolytic uremic syndrome in California, 1994-1999: Substantial underreporting and public health implications. Am J Epidemiol 2002, 155:941-8
3. Bell B, Goldoft M, Friffin P, et al: A multistate outbreak of Escherichia coli O157:H7-associated bloody diarrhea and hemolytic uremic syndrome from hamburgers. JAMA 1994, 272:1349-53
4. Obrig TG, Del Vecchio PJD, Brown JE, et al: Direct cytotoxic action of shiga toxin on human vascular endothelial cells. Infect Immun 1988, 56:2373-8
5. Boyd B, Lingwood C: Verotoxin receptor glycolipid in human renal tissue. Nephron 1989, 51:207-10
6. Lingwood CA: Verotoxin-binding in human renal sections. Nephron 1994, 66:21-8
7. Robson WLM, Leung AKC, Kaplan BS: Hemolytic-uremic syndrome. Curr Prob Pediatr 1993, 23:16-33
8. van Setten P, van Hinsbergh V, van der Velden T, et al: Effects of TNFa on verocytotoxin cytotoxicity in purified glomerular microvascular endothelial cells. Kidney Int 1997, 51:1245-56
9. Hughes A, Stricklett P, Kohan D: Cytotoxic effect of Shiga toxin-1 on human proximal tubule cells. Kidney Int 1998, 54:426-37
10. Hughes A, Stricklett P, Schmid D, Kohan D: Cytotoxic effect of Shiga toxin-1 on human glomerular epithelial cells. Kidney Int 2000, 57:2350-9
11. Dunagan W, Ridner M: Manual of Medical Therapeutics (Edited by: Waltham, MA) Little, Brown; 1989
12. Gunawardena K, Murray D, Meikle A: Testosterone is a potential augmenter of antioxidant-induced apoptosis in human prostate cancer cells. Cancer Detect Prev 2002, 26:105-13
13. van Setten P, van Hinsbergh V, van den Heuvel L, et al: Verocytotox-in inhibits mitogenesis and protein synthesis in purified human glomerular mesangial cells without affecting cell viability: evidence for two distinct mechanisms. J Am Soc Nephrol 1998, 8:1877-88
14. Taylor F, Tesh V, DeBault L, et al: Characterization of the baboon responses to shiga-like toxin. Am J Pathol 1999, 154:1285-99
15. Meseguer A, Catterall J: Mouse kidney androgen-regulated protein messenger ribonucleic acid is expressed in the proximal convoluted tubules. Mol Endocrinol 1987, 1:535-41
16. Cid M, Schnaper H, Kleinman H: Estrogens and the vascular endothelium. Ann N Y Acad Sci 2002, 966:143-57