Reproductive performance of women with müllerian anomalies

Current Opinion in Obstetrics and Gynecology

Volumn 19, Issue 3, 2007, Pages 229-237

  Rackow, Beth W ^a   Arici, Aydin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Congenital uterine anomalies; M llerian anomalies; Recurrent pregnancy loss; Septate uterus

Indexed keywords

DIETHYLSTILBESTROL;

ADENOCARCINOMA; AGENESIS; AMENORRHEA; ARCUATE UTERUS; DISEASE CLASSIFICATION; DYSMENORRHEA; ECHOGRAPHY; EMBRYO DEVELOPMENT; ENDOMETRIOSIS; FEMALE; FEMALE GENITAL TRACT MALFORMATION; FEMALE INFERTILITY; HUMAN; HYPOPLASIA; HYSTEROGRAPHY; HYSTEROSALPINGOGRAPHY; HYSTEROSCOPY; KARYOTYPE 46,XX; LAPAROSCOPY; MUELLERIAN DUCT; NUCLEAR MAGNETIC RESONANCE IMAGING; PELVIS PAIN SYNDROME; PREVALENCE; PRIORITY JOURNAL; RECURRENT ABORTION; REPRODUCTION; REVIEW; UTERINE CERVIX DISEASE; UTERUS BICORNIS; UTERUS BLEEDING; UTERUS DIDELPHYS; UTERUS MALFORMATION; UTERUS SEPTUS; UTERUS UNICORNIS; VAGINA APLASIA; VAGINA CARCINOMA; VAGINA DISEASE;

CARCINOGENS; DIETHYLSTILBESTROL; FEMALE; HUMANS; HYSTEROSALPINGOGRAPHY; MULLERIAN DUCTS; PREGNANCY; PREGNANCY OUTCOME; REPRODUCTION; UTERUS; VAGINA;

EID: 34248328322     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32814b0649     Document Type: Review

References (82)

1. Lin PC, Bhatnagar KP, Nettleton GS, Nakajima ST. Female genital anomalies affecting reproduction. Fertil Steril 2002; 78:899-915.
2. Propst AM, Hill JA 3rd. Anatomic factors associated with recurrent pregnancy loss. Semin Reprod Med 2000; 18:341-350.
3. Acien P. Incidence of müllerian defects in fertile and infertile women. Hum Reprod 1997; 12:1372-1376.
4. Grimbizis GF, Camus M, Tarlatzis BC, et al. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update 2001; 7:161-174.
5. Raga F, Bauset C, Remohi J, et al. Reproductive impact of congenital müllerian anomalies. Hum Reprod 1997; 12:2277-2281.
6. Simon C, Martinez L, Pardo F, et al. Müllerian defects in women with normal reproductive outcome. Fertil Steril 1991; 56:1192-1193.
7. Iverson RE, DeCherney AH, Laufer MR. Clinical manifestations and diagnosis of congenital anomalies of the uterus. In: Rose BD, editor. UpToDate. Waltham, MA: UpToDate; 2007. This review of congenital uterine anomalies discusses the associated developmental defects, presentation, obstetric and gynecologic complications, and evaluation.
8. Harger JH, Archer DF, Marchese SG, et al. Etiology of recurrent pregnancy losses and outcome of subsequent pregnancies. Obstet Gynecol 1983; 62:574-581.
9. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, müllerian anomalies and intrauterine adhesions. Fertil Steril 1988; 49:944-955.
10. Fedele L, Bianchi S, Frontino G. Septums and synechiae: approaches to surgical correction. Clin Obstet Gynecol 2006; 49:767-788. This is an excellent, comprehensive review of the septate uterus: diagnosis, reproductive consequences, and indications for surgical management.
11. Sanfilippo JS, Wakim NG, Schikler KN, Yussman MA. Endometriosis in association with uterine anomaly. Am J Obstet Gynecol 1986; 154:39-43.
12. Fedele L, Bianchi S. Hysteroscopic metroplasty for septate uterus. Obstet Gynecol Clin North Am 1995; 22:473-489.
13. Fedele L, Zamberletti D, Vercellini P, et al. Reproductive performance of women with unicornuate uterus. Fertil Steril 1987; 47:416-419.
14. Golan A, Langer R, Wexler S, et al. Cervical cerclage: its role in the pregnant anomalous uterus. Int J Fertil 1990; 35:164-170.
15. Leible S, Munoz H, Walton R, et al. Uterine artery blood flow velocity waveforms in pregnant women with müllerian duct anomaly: a biologic model for uteroplacental insufficiency. Am J Obstet Gynecol 1998; 178: 1048-1053.
16. Rock JA, Schlaff WD. The obstetric consequences of uterovaginal anomalies. Fertil Steril 1985; 43:681-692.
17. Strassmann EO. Fertility and unification of double uterus. Fertil Steril 1966; 17:165-176.
18. White MM. Uteroplasty in infertility. Proc R Soc Med 1960; 53:1006-1009.
19. Andrews MC, Jones HW Jr. Impaired reproductive performance of the unicornuate uterus: intrauterine growth retardation, infertility, and recurrent abortion in five cases. Am J Obstet Gynecol 1982; 144:173-176.
20. Ludmir J, Samuels P, Brooks S, Mennuti MT. Pregnancy outcome of patients with uncorrected uterine anomalies managed in a high-risk obstetric setting. Obstet Gynecol 1990; 75:906-910.
21. Acien P. Reproductive performance of women with uterine malformations. Hum Reprod 1993; 8:122-126.
22. Green LK, Harris RE. Uterine anomalies: frequency of diagnosis and associated obstetric complications. Obstet Gynecol 1976; 47:427-429.
23. Ludmir J, Landon MB, Gabbe SG, et al. Management of the diethylstilbestrolexposed pregnant patient: a prospective study. Am J Obstet Gynecol 1987; 157:665-669.
24. Jayasinghe Y, Rane A, Stalewski H, Grover S. The presentation and early diagnosis of the rudimentary uterine horn. Obstet Gynecol 2005; 105:1456-1467.
25. Pellerito JS, McCarthy SM, Doyle MB, et al. Diagnosis of uterine anomalies: relative accuracy of MR imaging, endovaginal sonography, and hysterosalpingography. Radiology 1992; 183:795-800.
26. Troiano RN, McCarthy SM. Müllerian duct anomalies: imaging and clinical issues. Radiology 2004; 233:19-34.
27. Reuter KL, Daly DC, Cohen SM. Septate versus bicornuate uteri: errors in imaging diagnosis. Radiology 1989; 172:749-752.
28. Nicolini U, Bellotti M, Bonazzi B, et al. Can ultrasound be used to screen uterine malformations? Fertil Steril 1987; 47:89-93.
29. Goldberg JM, Falcone T, Attaran M. Sonohysterographic evaluation of uterine abnormalities noted on hysterosalpingography. Hum Reprod 1997; 12:2151-2153.
30. Wu MH, Hsu CC, Huang KE. Detection of congenital müllerian duct anomalies using three-dimensional ultrasound. J Clin Ultrasound 1997; 25:487-492.
31. Homer HA, Li TC, Cooke ID. The septate uterus: a review of management and reproductive outcome. Fertil Steril 2000; 73:1-14.
32. Marcus S, al-Shawaf T, Brinsden P. The obstetric outcome of in vitro fertilization and embryo transfer in women with congenital uterine malformation. Am J Obstet Gynecol 1996; 175:85-89.
33. Devi Wold AS, Pham N, Arici A. Anatomic factors in recurrent pregnancy loss. Semin Reprod Med 2006; 24:25-32. This paper reviews the role of congenital and acquired uterine abnormalities in recurrent pregnancy loss, and includes a discussion of the impact of müllerian anomalies on RPL.
34. Iverson RE, DeCherney AH, Laufer MR. Surgical management of congenital uterine anomalies. In: Rose BD, editor. UpToDate. Waltham, MA: UpToDate; 2007. This review outlines current indications for surgery and surgical approaches for congenital uterine anomalies.
35. Nahum GG. Uterine anomalies: how common are they, and what is their distribution among subtypes? J Reprod Med 1998; 43:877-887.
36. Acien P, Acien M, Sanchez-Ferrer M. Complex malformations of the female genital tract: new types and revision of classification. Hum Reprod 2004; 19:2377-2384.
37. Abramovici H, Faktor JH, Pascal B. Congenital uterine malformations as indication for cervical suture (cerclage) in habitual abortion and premature delivery. Int J Fertil 1983; 28:161-164.
38. Heinonen PK, Saarikoski S, Pystynen P. Reproductive performance of women with uterine anomalies: an evaluation of 182 cases. Acta Obstet Gynecol Scand 1982; 61:157-162.
39. Wajntraub G, Milwidsky A, Weiss D. Prevention of premature delivery in a unicornuate uterus by cervical cerclage. Acta Obstet Gynecol Scand 1975; 54:497-498.
40. Sarto GE, Simpson JL. Abnormalities of the müllerian and wolffian duct systems. Birth Defects Orig Artic Ser 1978; 14:37-54.
41. Gholoum S, Puligandla PS, Hui T, et al. Management and outcome of patients with combined vaginal septum, bifid uterus, and ipsilateral renal agenesis (Herlyn-Werner-Wunderlich syndrome). J Pediatr Surg 2006; 41:987-992. This is a nice review of the presentation, management, and outcome of females with a rare müllerian anomaly: uterine didelphys with an obstructed hemivagina and ipsilateral renal agenesis.
42. Heinonen PK. Complete septate uterus with longitudinal vaginal septum. Fertil Steril 2006; 85:700-705. This study investigates the reproductive outcomes and long-termconsequences of women with complete septate uterus and longitudinal vaginal septum, and identifies better reproductive outcomes compared with previous studies. The results encourage judicious use of the hysteroscopic metroplasty procedure.
43. Mirkovic L, Ljubic A, Mirkovic D. Magnetic resonance imaging in the evaluation of uterus didelphys with obstructed hemivagina and renal agenesis: a case report. Arch Gynecol Obstet 2006; 274:246-247. This case report emphasizes the importance of MRI when evaluating and managing müllerian anomalies.
44. Musich JR, Behrman SJ. Obstetric outcome before and after metroplasty in women with uterine anomalies. Obstet Gynecol 1978; 52:63-66.
45. Fedele L, Bianchi S, Marchini M, et al. Ultrastructural aspects of endometrium in infertile women with septate uterus. Fertil Steril 1996; 65:750-752.
46. Fedele L, Ferrazzi E, Dorta M, et al. Ultrasonography in the differential diagnosis of 'double' uteri. Fertil Steril 1988; 50:361-364.
47. Blum M. Prevention of spontaneous abortion by cervical suture of the malformed uterus. Int Surg 1977; 62:213-215.
48. Haddad B, Louis-Sylvestre C, Poitout P, Paniel BJ. Longitudinal vaginal septum: a retrospective study of 202 cases. Eur J Obstet Gynecol Reprod Biol 1997; 74:197-199.
49. Nawroth F, Rahimi G, Nawroth C, et al. Is there an association between septate uterus and endometriosis? Hum Reprod 2006; 21:542-544. This interesting paper identifies a higher incidence of endometriosis in women with septate uteri. Therefore, laparoscopy may be warranted in women with septate uteri, and endometriosis may be an etiology of infertility in these women.
50. Woelfer B, Salim R, Banerjee S, et al. Reproductive outcomes in women with congenital uterine anomalies detected by three-dimensional ultrasound screening. Obstet Gynecol 2001; 98:1099-1103.
51. Candiani GB, Fedele L, Zamberletti D, et al. Endometrial patterns in malformed uteri. Acta Eur Fertil 1983; 14:311-318.
52. Dabirashrafi H, Bahadori M, Mohammad K, et al. Septate uterus: new idea on the histologic features of the septum in this abnormal uterus. Am J Obstet Gynecol 1995; 172:105-107.
53. Patton PE, Novy MJ, Lee DM, Hickok LR. The diagnosis and reproductive outcome after surgical treatment of the complete septate uterus, duplicated cervix and vaginal septum. Am J Obstet Gynecol 2004; 190:1669-1675; discussion 1675-1678.
54. Rock JA, Roberts CP, Hesla JS. Hysteroscopic metroplasty of the class Va uterus with preservation of the cervical septum. Fertil Steril 1999; 72:942-945.
55. Parsanezhad ME, Alborzi S, Zarei A, et al. Hysteroscopic metroplasty of the complete uterine septum, duplicate cervix, and vaginal septum. Fertil Steril 2006; 85:1473-1477. The findings in this small study support a change in the routine practice of preserving the cervical septum during hysteroscopic metroplasty for a complete uterine septum, but longer patient follow-up is necessary.
56. Candiani GB, Vercellini P, Fedele L, et al. Repair of the uterine cavity after hysteroscopic septal incision. Fertil Steril 1990; 54:991-994.
57. Dabirashrafi H, Mohammad K, Moghadami-Tabrizi N, et al. Is estrogen necessary after hysteroscopic incision of the uterine septum? J Am Assoc Gynecol Laparosc 1996; 3:623-625.
58. Vercellini P, Fedele L, Arcaini L, et al. Value of intrauterine device insertion and estrogen administration after hysteroscopic metroplasty. J Reprod Med 1989; 34:447-450.
59. Ashton D, Amin HK, Richart RM, Neuwirth RS. The incidence of asymptomatic uterine anomalies in women undergoing transcervical tubal sterilization. Obstet Gynecol 1988; 72:28-30.
60. Pabuccu R, Gomel V. Reproductive outcome after hysteroscopic metroplasty in women with septate uterus and otherwise unexplained infertility. Fertil Steril 2004; 81:1675-1678.
61. Fedele L, Arcaini L, Parazzini F, et al. Reproductive prognosis after hysteroscopic metroplasty in 102 women: life-table analysis. Fertil Steril 1993; 59:768-772.
62. Choe JK, Baggish MS. Hysteroscopic treatment of septate uterus with neodymium-YAG laser. Fertil Steril 1992; 57:81-84.
63. Daly DC, Maier D, Soto-Albors C. Hysteroscopic metroplasty: six years' experience. Obstet Gynecol 1989; 73:201-205.
64. Herbst AL, Hubby MM, Azizi F, Makii MM. Reproductive and gynecologic surgical experience in diethylstilbestrol-exposed daughters. Am J Obstet Gynecol 1981; 141:1019-1028.
65. Kaufman RH, Adam E, Binder GL, Gerthoffer E. Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol. Am J Obstet Gynecol 1980; 137:299-308.
66. Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 1971; 284:878-881.
67. Goldberg JM, Falcone T. Effect of diethylstilbestrol on reproductive function. Fertil Steril 1999; 72:1-7.
68. Levine RU, Berkowitz KM. Conservative management and pregnancy outcome in diethylstilbestrol-exposed women with and without gross genital tract abnormalities. Am J Obstet Gynecol 1993; 169:1125-1129.
69. Deffarges JV, Haddad B, Musset R, Paniel BJ. Utero-vaginal anastomosis in women with uterine cervix atresia: long-term follow-up and reproductive performance: a study of 18 cases. Hum Reprod 2001; 16:1722-1725.
70. Buttram VC Jr. Müllerian anomalies and their management. Fertil Steril 1983; 40:159-163.
71. Fujimoto VY, Miller JH, Klein NA, Soules MR. Congenital cervical atresia: report of seven cases and review of the literature. Am J Obstet Gynecol 1997; 177:1419-1425.
72. Burgis J. Obstructive müllerian anomalies: case report, diagnosis, and management. Am J Obstet Gynecol 2001; 185:338-344.
73. Evans TN, Poland ML, Boving RL. Vaginal malformations. Am J Obstet Gynecol 1981; 141:910-920.
74. Petrozza JC, Gray MR, Davis AJ, Reindollar RH. Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic trait: outcomes of surrogate pregnancies. Fertil Steril 1997; 67:387-389.
75. ACOG Committee Opinion No. 355: Vaginal agenesis: diagnosis, management, and routine care. Obstet Gynecol 2006; 108:1605-1609. This excellent, thorough review discusses the differential diagnosis of vaginal agenesis, evaluation, nonsurgical and surgical approaches to creation of a neovagina, and general gynecologic care.
76. Fore SR, Hammond CB, Parker RT, Anderson EE. Urologic and genital anomalies in patients with congenital absence of the vagina. Obstet Gynecol 1975; 46:410-416.
77. Guerrier D, Mouchel T, Pasquier L, Pellerin I. The Mayer-Rokitansky- Kuster-Hauser syndrome (congenital absence of uterus and vagina): phenotypic manifestations and genetic approaches. J Negat Results Biomed 2006; 5:1. This review outlines the congenital anomalies associated with congenital absence of the uterus and vagina, and discusses current knowledge about the genetics of Mayer-Rokitansky-Kuster-Hauser syndrome.
78. Oppelt P, Renner SP, Kellermann A, et al. Clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging. Hum Reprod 2006; 21:792-797. This paper identifies that patients with Mayer-Rokitansky-Kuster-Hauser syndrome have a high rate of associated malformations, and recommends new guidelines for standard diagnostic classification.
79. Pittock ST, Babovic-Vuksanovic D, Lteif A. Mayer-Rokitansky-Kuster-Hauser anomaly and its associated malformations. Am J Med Genet A 2005; 135:314-316.
80. Bates GW, Wiser WL. A technique for uterine conservation in adolescents with vaginal agenesis and a functional uterus. Obstet Gynecol 1985; 66: 290-294.
81. Salvatore CA, Lodovicci O. Vaginal agenesis: an analysis of ninety cases. Acta Obstet Gynecol Scand 1978; 57:89-94.
82. Wood EG, Batzer FR, Corson SL. Ovarian response to gonadotrophins, optimal method for oocyte retrieval and pregnancy outcome in patients with vaginal agenesis. Hum Reprod 1999; 14:1178-1181.