Elevated antibody response by antigen presentation in immune complexes

Medical Science Monitor

Volumn 13, Issue 5, 2007, Pages

  Barabas, Arpad Zsigmond ^a   Cole, Chad Douglas ^b   Kovacs, Zoltan Bernat ^a   Lafreniere, Rene ^a  

^a Health Sciences Centre Calgary   (Canada)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody information transfer; Immune complex; Immune response; Prophylactic vaccination; Therapeutic vaccination

Indexed keywords

FREUND ADJUVANT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ACTIVE IMMUNIZATION; AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; KIDNEY DISEASE; MALE; NONHUMAN; RAT; VACCINATION;

ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; ANTIGEN-ANTIBODY COMPLEX; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN G; MALE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; VACCINATION;

EID: 34248218486     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Barabas AZ, Cole CD, Barabas AD, Lafreniere R: Production of a new model of slowly progressive Heymann nephritis. Int J Exp Pathol, 2003; 84: 245-58
2. Barabas AZ, Cole CD, Barabas AD, Lafreniere R: Down-regulation of pathogenic autoantibody response in a slowly progressive Heymann nephritis kidney disease model. Int J Exp Pathol, 2004; 85: 321-34
3. Barabas AZ, Cole CD, Barabas AD, Lafreniere R: Downregulation of pathogenic autoantibody response by IgM autoantibodies directed against the nephritogenic antigen in slowly progressive Heymann nephritis. Pathol Int, 2006; 56: 181-90
4. Weichelbaum TD: Accurate and rapid method for determination of proteins in small amounts of blood, serum and plasma. Am J Clin Path Tech Suppl, 1946; 10: 40-49
5. Heyman B: Regulation of antibody responses via antibodies, complement, and Fc receptors. Annu Rev Immunol, 2000; 18: 709-37
6. Leskowitz S: Studies in immunization. II. Immunization with specific precipitates. J Immunol, 1960; 85: 56-66
7. Terres G, Wolins W: Enhanced sensitization in mice by simultaneous injection of antigen and specific rabbit antiserum. Proc Soc Exp Biol Med, 1959; 102: 632-35
8. Terres G, Wolins W: Enhanced immunological sensitization of mice by the simultaneous injection of antigen and specific antiserum. I. Effect of varying the amount of antigen used relative to the antiserum. J Immunol, 1961; 86: 361-68
9. Terres G, Stoner RD: Specificity of enhanced immunological sensitization of mice following injections of antigens and specific antisera. Proc Soc Exp Biol Med, 1962; 109: 88-91
10. Barabas AZ, Lafreniere R: Antigen-specific down-regulation of immunopathological events in an experimental autoimmune kidney disease. Autoimmun Rev, 2005; 4: 565-70
11. Barabas AZ, Cole CD, Barabas AD et al: Reduced incidence of slowly progressive Heymann nephritis in rats immunized with a modified vaccination technique. Clin Dev Immunol, 2006; 13: 17-24
12. Barabas AZ, Cole CD, Barabas AD et al: Effect of rat kidney fraction 3 (rKF3) antigen and specific IgM antibody against rKF3 on the progression of slowly progressive Heymann nephritis. Pathol Int, 2006; 56: 516-29
13. Klaus GG: The generation of memory cells. II. Generation of B memory cells with preformed antigen-antibody complexes. Immunology, 1978; 34: 643-52
14. Klaus GG: Generation of memory cells. III. Antibody class requirements for the generation of B-memory cells by antigen-antibody complexes. Immunology, 1979; 37: 345-51
15. Terres G, Stoner RD: Specificity of enhanced immunological sensitization of mice following injections of antigens and specific antisera. Proc Soc Exp Biol Med, 1962; 109: 88-91
16. Leskowitz S: Studies in immunization. II. Immunization with specific precipitates. J Immunol, 1960; 85: 56-66
17. Kunkl A, Klaus GG: The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response. Immunology, 1981; 43: 371-78
18. Terres G, Habicht GS, Stoner RD: Carrier-specific enhancement of the immune response using antigen-antibody complexes. J Immunol, 1974; 112: 804-11
19. Hamaoka T, Kitagawa M: Antibody production in mice. II. The mechanism of antigenic stimulation in the secondary immune response. Immunology, 1971; 20: 191-203