The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats

Journal of Physiology and Pharmacology

Volumn 58, Issue 1, 2007, Pages 105-116

  Yildirim, Abdulkadir ^a   Sahin, Y N ^a   Suleyman, H ^a   Yilmaz, A ^a   Yildirim, S ^a  

^a ATATURK UNIVERSITY   (Turkey)

Author keywords

Adrenalectomy; Antioxidants; Epinephrine; Lipid peroxidation; Prednisolone

Indexed keywords

ADRENALIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; PREDNISOLONE; SUPEROXIDE DISMUTASE; ANTIOXIDANT;

ADRENALECTOMY; ANIMAL TISSUE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; ENZYME ACTIVITY; ERYTHROCYTE; LIPID PEROXIDATION; MALE; NONHUMAN; RAT; ANIMAL; METABOLISM; METHODOLOGY; OXIDATIVE STRESS; RANDOMIZATION; STOMACH; WISTAR RAT;

ADRENALECTOMY; ANIMALS; ANTIOXIDANTS; COLORIMETRY; EPINEPHRINE; ERYTHROCYTES; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PREDNISOLONE; RANDOM ALLOCATION; RATS; RATS, WISTAR; STOMACH; SUPEROXIDE DISMUTASE;

EID: 34248211663     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Loguercio C, Taranto D, Beneduce F, et al.: Glutathione prevents ethanol induced gastric mucosal damage and depletion of sulfhydryl compounds in humans. Gut 1993;34:161-165.
2. Samuni A, Karmeli F, Moshen M, Rachmilewitz D: Mechanisms underlying gastric antiulcerative activity of nitroxides in rats. Free Radic Res 1999;30:133-140.
3. Hsu DZ, Wang ST, Deng JF, Liu MY: Epinephrine protects against severe acute gastric bleeding in rats: role of nitric oxide and glutathione. Shock 2005;23:253-257.
4. Kanemasa H, Ozawa H, Konishi H, et al.: Distribution of glucocorticoid receptor immunoreactivity in gastric mucosa of normal and adrenalectomized rats. Dig Dis Sci 1999;44:2081-2087.
5. Hernandez DE, Adcock JW, Nemeroff CB, Prange AJ, Jr.: The role of the adrenal gland in cytoprotection against stress-induced gastric ulcers in rats. J Neurosci Res 1984;11:193-201.
6. Avunduk C, Eastwood GL, Polakowski N, Quimby GF: Effects of stress on gastric mucosal prostaglandin generation in intact, adrenalectomized, and sham-operated rats. J Clin Gastroenterol 1990; 12 Suppl 1:S48-51.
7. Stetinova V, Grossmann V: Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). Exp Toxicol Pathol 2000;52:473-479.
8. Urushidani T, Kasuya Y, Okabe S: The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat. Jpn J Pharmacol 1979;29:775-780.
9. Takeuchi K, Nishiwaki H, Okada M, et al.: Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility. Gastroenterology 1989;97:284-293.
10. Salim AS: Oxygen-derived free radicals and the prevention of duodenal ulcer relapse: a new approach. Am J Med Sci 1990;300:1-6; discussion 7-8.
11. Bhattacharjee M, Bhattacharjee S, Gupta A, Banerjee RK: Critical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and nonmediated gastric ulcer. Free Radic Biol Med 2002;32:731-743.
12. Naito Y, Yoshikawa T, Ando T, et al.: Changes in superoxide dismutase activity in the gastric mucosa of peptic ulcer patients. J Clin Gastroenterol 1992;14 Suppl 1:S131-134.
13. Hirokawa K, Kawasaki H: Changes in glutathione in gastric mucosa of gastric ulcer patients. Res Commun Mol Pathol Pharmacol 1995;88:163-176.
14. Oshima A, Asayama K, Sakai N, Kitajima M: The role of endogenous free radical scavengers on tissue recovery in the experimental ulcer model. J Clin Gastroenterol 1990;12 Suppl 1:S58-64.
15. Mehta JL, Li D: Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med 2001;30:148-153.
16. Schmidt AJ, Krieg JC, Vedder H: Differential effects of glucocorticoids and gonadal steroids on glutathione levels in neuronal and glial cell systems. J Neurosci Res 2002;67:544-550.
17. Pereira B, Rosa LF, Safi DA, et al.: Hormonal regulation of superoxide dismutase, catalase, and glutathione peroxidase activities in rat macrophages. Biochem Pharmacol 1995;50:2093-2098.
18. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-169.
19. Durak I, Yurtarslanl Z, Canbolat O, Akyol O: A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta 1993;214:103-104.
20. Okhawa H, Ohishi N, Yagi K: Assay for lipid peroxidase in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351.
21. Tietze F: Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-522.
22. Eldrup E, Mogensen P, Jacobsen J, et al.: CSF and plasma concentrations of free norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxyphenylalanine (DOPA), and epinephrine in Parkinson's disease. Acta Neurol Scand 1995;92:116-121.
23. Eldrup E, Richter EA, Christensen NJ: DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA. Am J Physiol 1989;256:E284-287.
24. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
25. Fairbanks V, Klee G: Measurement of hemoglobin concentration in whole blood. In Tietz N (ed): "Textbook of Clinical Chemistry." WB Sounders Co, 1986:1532-1534.
26. Menguy R: Effects of restraint stress on gastric secretion in the rat. Am J Dig Dis 1960;5:911-916.
27. Brodie DA, Hanson HM: A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology 1960;38:353-360.
28. Toleikis PM, Godin DV: Alteration of antioxidant status following sympathectomy: differential effects of modified plasma levels of adrenaline and noradrenaline. Mol Cell Biochem 1995;152:39-49.
29. Hidalgo J, Gasull T, Garcia A, et al.: Role of glucocorticoids and catecholamines on hepatic thiobarbituric acid reactants in basal and stress conditions in the rat. Horm Metab Res 1991;23:104-109.
30. Kwiecien S, Brzozowski T, Konturek PC, et al.: Gastroprotection by pentoxyfilline against stress-induced gastric damage. Role of lipid peroxidation, antioxidizing enzymes and proinflammatory cytokines. J Physiol Pharmacol 2004;55:337-355.
31. Suwa T, Mune T, Morita H, et al.: Role of rat adrenal antioxidant defense systems in the aldosterone turn-off phenomenon. J Steroid Biochem Mol Biol 2000;73:71-78.
32. Stein HJ, Hinder RA, Oosthuizen MM: Gastric mucosal injury caused by hemorrhagic shock and reperfusion: protective role of the antioxidant glutathione. Surgery 1990;108:467-473; discussion 473-464.
33. Romano M, Razandi M, Raza A, et al.: Cysteamine protects gastric epithelial cell monolayers against drug induced damage: evidence for direct cellular protection by sulphydryl compounds. Gut 1992;33:30-38.
34. Tsukimi Y, Okabe S: Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing. Biol Pharm Bull 2001;24:1-9.
35. Pereira B, Costa-Rosa LF, Bechara EJ, et al.: Changes in the TBARs content and superoxide dismutase, catalase and glutathione peroxidase activities in the lymphoid organs and skeletal muscles of adrenodemedullated rats. Braz J Med Biol Res 1998;31:827-833.
36. Allen DR, Wallis GL, McCay PB: Catechol adrenergic agents enhance hydroxyl radical generation in xanthine oxidase systems containing ferritin: implications for ischemia/reperfusion. Arch Biochem Biophys 1994;315:235-243.
37. Bindoli A, Rigobello MP, Deeble DJ: Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radic Biol Med 1992;13:391-405.
38. Carpagnano GE, Kharitonov SA, Resta O, et al.: 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest 2003;124:1386-1392.
39. Kawamura T, Yoshioka T, Bills T, et al.: Glucocorticoid activates glomerular antioxidant enzymes and protects glomeruli from oxidant injuries. Kidney Int 1991;40:291-301.
40. Asayama K, Hayashibe H, Dobashi K, et al.: Effect of dexamethasone on antioxidant enzymes in fetal rat lungs and kidneys. Biol Neonate 1992;62:136-144.