Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase

Biochemistry

Volumn 46, Issue 18, 2007, Pages 5446-5454

  Meijers, Rob ^a,f   Adolph, Hans Werner ^b   Dauter, Zbigniew ^c   Wilson, Keith S ^d   Lamzin, Victor S ^a   Cedergren Zeppezauer, Eila S ^e  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF YORK   (United Kingdom)

^e LUND UNIVERSITY   (Sweden)

^f SYNCHROTRON SOLEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; METAL IONS; MOLECULAR STRUCTURE; SUBSTITUTION REACTIONS; SUBSTRATES;

ENZYME FUNCTION; FLASH-FREEZING PROTOCOL; HYDROXIDE ION;

ENZYME INHIBITION;

ALCOHOL DEHYDROGENASE; ALDEHYDE REDUCTASE; CADMIUM; COORDINATION COMPOUND; DIMETHYL SULFOXIDE; HYDROXIDE; ISOBUTYRIC ACID; LIGAND; METAL; PYRIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE SWITCHING; INHIBITION KINETICS; PRIORITY JOURNAL;

ALCOHOL DEHYDROGENASE; ANIMALS; BINDING SITES; CADMIUM; CRYSTALLOGRAPHY, X-RAY; HORSES; LIGANDS; LIVER; NAD; ZINC;

EID: 34248205214     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi6023594     Document Type: Article

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