Locally administered antibiotics for prophylaxis against surgical wound infection: An in vivo study

Journal of Bone and Joint Surgery

Volumn 89, Issue 5, 2007, Pages 929-933

  Yarboro, Seth R ^a   Baum, Elyse J ^a   Dahners, Laurence E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SULFATE; GENTAMICIN; TYROTHRICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTERIAL COUNT; BACTERIUM CULTURE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; RAT; STAPHYLOCOCCUS AUREUS; SURGICAL INFECTION;

EID: 34248176206     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.F.00919     Document Type: Article

References (14)

1. Consensus paper on the surveillance of surgical wound infections. The Society for Hospital Epidemiology of America; The Association for Practitioners in Infection Control; The Centers for Disease Control; The Surgical Infection Society. Infect Control Hosp Epidemiol. 1992;13:599-605.
2. Horan TC, Gaynes RP Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13:606-8.
3. Page CP, Bohnen JM, Fletcher JR, McManus AT, Solomkin JS, Wittmann DH. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care. Arch Surg. 1993;128:79-88. Erratum in: Arch Surg. 1993;128:410.
4. Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res. 2005;437:97-104.
5. Hanssen AD. Local antibiotic delivery vehicles in the treatment of musculoskeletal infection. Clin Orthop Relat Res. 2005;437:91-6.
6. Dahners LE, Funderburk CH. Gentamicin-loaded plaster of Paris as a treatment of experimental osteomyelitis in rabbits. Clin Orthop Relat Res. 1987; 219:278-82.
7. Abramowicz M. Antimicrobial prophylaxis in surgery. Med Lett Drugs Ther. 1999;41:75-80.
8. Eron LJ. Prevention of infection following orthopedic surgery. Antibiot Chemother. 1985;33:140-64.
9. Benjamin JB, Volz RG. Efficacy of a topical antibiotic irrigant in decreasing or eliminating bacterial contamination in surgical wounds. Clin Orthop Relat Res. 1984;184:114-7.
10. Hawk CT, editor. Formulary for laboratory animals. 3rd ed. Ames, Iowa: Blackwell; 2005.
11. Veterinary pharmaceuticals and biologicals. 12th ed. Lenexa, Kansas: Veterinary Medicine; 2001.
12. Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE. Bone toxicity of locally applied aminoglycosides. J Orthop Trauma. 1995;9:401-6.
13. Humphrey JS, Mehta S, Seaber AV, Vail TP. Pharmacokinetics of a degradatale drug delivery system in bone. Clin Orthop Relat Res. 1998;349:218-24.
14. Miclau T, Dahners LE, Lindsey RW. In vitro pharmacokinetics of antibiotic release from locally implantable materials. J Orthop Res. 1993;11:627-32.