The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention [1]

Diabetologia

Volumn 50, Issue 6, 2007, Pages 1345-1347

  Rittig, K ^a   Thamer, C ^a   Machicao, F ^a   Rietig, R ^a   Stefan, N ^a   Fritsche, A ^a   Haring, H U ^a   Balletshofer, B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE;

AGE DISTRIBUTION; ALLELE; BODY MASS; CARDIOVASCULAR DISEASE; CODON; DNA POLYMORPHISM; EXERCISE; FOLLOW UP; GENE INTERACTION; GENOTYPE; GLUCOSE METABOLISM; HEREDITY; HUMAN; LETTER; LIFESTYLE MODIFICATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; WEIGHT REDUCTION;

ALANINE; AMINO ACID SUBSTITUTION; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; DIETARY CARBOHYDRATES; DIETARY FATS; LIFE STYLE; POLYMERASE CHAIN REACTION; PPAR GAMMA; PROLINE; VASODILATION;

EID: 34248175043     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0664-6     Document Type: Letter

References (10)

1. Ordovas JM (2004) The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc Nutr Soc 63:145-152
2. Goldstein LB, Adams R, Alberts MJ et al (2006) Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and MetabolismCouncil; and theQuality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 113:e873-e923
3. Semple RK, Chatterjee VK, O'Rahilly S (2006) PPAR gamma and human metabolic disease. J Clin Invest 116:581-589
4. Tuomilehto J, Lindstrom J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
5. Balletshofer BM, Rittig K, Enderle MD et al (2000) Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation 101:1780-1784
6. Yen CJ, Beamer BA, Negri C et al (1997) Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem Biophys Res Commun 241:270-274
7. Margareta EK, Westborg CJ, Eliasson MC (2006) A randomized trial of lifestyle intervention in primary healthcare for the modification of cardiovascular risk factors. Scand J Public Health 34:453-461
8. Haffner S, Temprosa M, Crandall J et al (2005) Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 54:1566-1572
9. Temelkova-Kurktschiev T, Hanefeld M, Chinetti G et al (2004) Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. J Clin Endocrinol Metab 89:4238-4242
10. Tonjes A, Scholz M, Loeffler M, Stumvoll M (2006) Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 29:2489-2497