Toosendanin modifies K+- and Ca2+-channel activity and intracellular Ca2+ concentration

Progress in Biochemistry and Biophysics

Volumn 34, Issue 2, 2007, Pages 132-137

  Shi, Yu Liang ^a   Wang, Wen Ping ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Intracellular Ca2+ concentration; K+ channel; L type Ca2+ channel; Toosendanin

Indexed keywords

HEXAPODA; MELIA; MELIACEAE;

EID: 34248170120     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Shi Y L. Toosendanin, a new presynaptic blocker. In: Chen Y C, Yuan S L, eds. Study and Utility of Toxins, Beijing: Science Press, 1988. 192-206
2. Shi Y L. Chinaberry and toosendanin. In: Liu D Y, eds. Exploitation and Utility of Biotoxins, Beijing: Chemical Industrial Press, 2006
3. Shi Y L, Wei N S, Yang Y Q, et al. Acta Physiol Sin, 1980, 32 (3): 293-297
4. Shi Y L, Chen W Y. Effect of toosendanin on acetylcholine level of rat brain, a microdialysis study. Brain Res, 1999, 850: 173-178
5. Chen W Y, Yin P B, Ye W L, et al. Toosendanin-induced change of dopamine level detected by microdialysis in vivo at rat striatum. Chin Sci Bull, 1999, 44 (5): 1106-1110
6. Shi Y L, Yang Y Q, Wang W P, et al. Acta Physiol Sin, 1981, 33 (2): 141-146
7. Shi Y L, Wang W P, Xu K. Acta Physiol Sin, 1981, 33 (3): 259-265
8. Shi Y L, Wang W P, Yan S Q, et al. Acta Physiol Sin, 1982, 34 (3): 304-309
9. Shi Y L, Wang Z F. Cure of experimental botulism and antibotulismic effect of toosendanin. Acta Pharmacol Sin, 2004, 25 (6): 839-848
10. Li P Z, Zhou J, Miao W Y, et al. Chin Tradit Herb Drugs, 1982, 13 (6): 28-30
11. Shi Y L, Xu K. Chin Sci Bull, 28 (14): 885-887
12. Shi Y L, Xu K. Anti-botulismic effect of toosendanin and its facilitatory action on miniature end-plate potentials. Jap J Physiol, 1983, 33: 677-680
13. Shi Y L, Tang M Z. Chin J Neurosci, 2004, 20 (6): 461-465
14. Tang M Z, Wang Z F, Shi Y L. Toosendanin induces outgrowth of neuronal processes and apoptosis in PC12 cells. Neurosci Res, 2003, 45 (2): 225-231
15. Tang M Z, Wang Z F, Shi Y L. Involvement of cytochrome c release and caspase activation in toosendanin-induced PC12 cell apoptosis. Toxicology, 2004, 201: 31-38
16. Zhang B, Wang Z F, Tang M Z, et al. Growth inhibition and apoptosis-induced effect on human cancer cell lines of toosendanin, a triterpenoid derivative from Chinese traditional medicine. Invest New Drugs, 2005, 23: 547-553
17. Shi Y L, Wang W P, Liao C Y, et al. Atca Entomal Sin, 1986, 29 (3): 233-239
18. Chiu S F. Recent advances in research on botanical insecticides in China. In Arnason J T, Philogene B J R, Morand P, eds. Insecticides of Plant Origin. Am Chem Soc Symp Ser 387, Washington, DC: American Chemical Society, 1989. 69-77
19. Carpinella M C, Defago M T, Valladare S G, et al. Antifeedant and insecticide properties of a limonoid from Melia azedarach (Meliaceac) with potential use pest management. J Agric Chem, 2003, 51: 369-374
20. Zhang X , Wang X L, Feng J T. Acta Northwe Uni Agricul Sin, 1993, 21 (1): 1-5
21. Mallart A. Presynaptic currents in frog motor endings. Pflugers Arch, 1984, 400:8-13
22. Xu Y F, Shi Y L. Action of toosendanin on the membrane current of motor nerve terminals. Brain Res, 1993, 631:46-50
23. Hu Q, Huang F S, Shi Y L. Inhibition of toosendanin on the delayed rectifier potassium current in neuroblastomaxglioma NG108-15 cells. Brain Res, 1997, 751:47-53
24. + channels in hippocampal neurons by toosendanin. Neuroscience, 2001, 104 (1): 41-47
25. Wang Z F, Shi Y L. Toosendnin-induced inhibition of small-conductance calcium-activated potassium channels in CA1 pyramidal neuron of rat hippocampus. Neurosci Lett, 2001, 303: 13-16
26. Wang Z F, Shi Y L. Modulation of inward rectifier potassium channel by toosendanin, a presynaptic blocker. Neurosci Res, 2001, 40:211-215
27. Gao X D, Tang S B, Lu J, et al. Effects of toosendanin on electric and mechanical properties of guinea pig papillary muscles. Acta Pharmacol Sin, 1994, 15 (2): 147-151
28. Shi Y L, Sawanoborri T, Hireoka M, et al. CAPS New Commu, 1992, 11(Suppl 1): 44-45
29. 2+ conductance increase in neuroblastomaglioma hybrid cells. Chin Sci Bull, 1993, 38 (17):1489-1493
30. 2+ channels. Acta Pharmacol Sin, 2004, 25 (5): 597-601
31. 2+ currents in mouse and frog motor nerve terminals. Neurosci Res, 2001, 41: 243-249
32. 2+ current in NG108-15 cells via L-type channels. Neurosci Res, 2004, 49 (2): 197-203
33. 2+-influx in NG108-15 cells. Toxicon, 2004, 45: 53-60
34. Cohen N M, Lederer W J. Calcium current in isolated neonatal rat ventricular myocytes. J Biol Chem, 1987, 391: 169-191
35. 2+ channels in neonatal rat ventricular cells. Eur J Pharmacol, 2004, 501: 71-78
36. Shi Y L, Wang W P. Acta Physiol Sin, 2006, 58 (5): 397-406
37. Zhou J Y, Wang Z F, Ren X M, et al. Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin. FEBS Lett, 2003, 555:375-379
38. Li M F, Shi Y L. Toosendanin inhibits pore formation of botulinum toxin type A at PC12 cell membrane. Acta Pharmacol Sin, 2006, 27 (1): 66-70