-
1
-
-
0027935778
-
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
-
Andersson, T., Miners, J. O., Veronese, M. E., and Birkett, D. J., Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br. J. Clin. Pharmacol., 38, 131-137 (1994).
-
(1994)
Br. J. Clin. Pharmacol
, vol.38
, pp. 131-137
-
-
Andersson, T.1
Miners, J.O.2
Veronese, M.E.3
Birkett, D.J.4
-
2
-
-
0030967388
-
(2-Methyl-5-(methylsulfonyl) benzoyl)guanidine Na+/H+ antiporter inhibitors
-
Baumgarth, M., Beier, N., and Gericke, R., (2-Methyl-5-(methylsulfonyl) benzoyl)guanidine Na+/H+ antiporter inhibitors. J. Med. Chem., 40, 2017-2034 (1997).
-
(1997)
J. Med. Chem
, vol.40
, pp. 2017-2034
-
-
Baumgarth, M.1
Beier, N.2
Gericke, R.3
-
3
-
-
0031743851
-
Autoactivation and activation of the cytochrome P450s
-
Ekins, S., Ring, B. J., Binkley, S. N., Hall, S. D., and Wrighton, S. A., Autoactivation and activation of the cytochrome P450s. Int. J. Clin. Pharmacol. Ther., 36, 642-651 (1998).
-
(1998)
Int. J. Clin. Pharmacol. Ther
, vol.36
, pp. 642-651
-
-
Ekins, S.1
Ring, B.J.2
Binkley, S.N.3
Hall, S.D.4
Wrighton, S.A.5
-
4
-
-
0035953078
-
Discovery of zoniporide: A potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility
-
Guzman-Perez, A., Wester, R. T., Allen, M. C., Brown, J. A., Buchholz, A. R., Cook, E. R., Day, W. W., Hamanaka, E. S., Kennedy, S. P., Knight, D. R., Kowalczyk, P. J., Marala, R. B., Mularski, C. J., Novomisle, W. A., Ruggeri, R. B., Tracey, W. R., and Hill, R. J., Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg. Med. Chem. Lett, 11, 803-807 (2001).
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 803-807
-
-
Guzman-Perez, A.1
Wester, R.T.2
Allen, M.C.3
Brown, J.A.4
Buchholz, A.R.5
Cook, E.R.6
Day, W.W.7
Hamanaka, E.S.8
Kennedy, S.P.9
Knight, D.R.10
Kowalczyk, P.J.11
Marala, R.B.12
Mularski, C.J.13
Novomisle, W.A.14
Ruggeri, R.B.15
Tracey, W.R.16
Hill, R.J.17
-
5
-
-
0032749318
-
The myocardial Na(+)-H(+) exchange: Structure, regulation, and its role in heart disease
-
Karmazyn, M., Gan, X. T., Humphreys, R. A., Yoshida, H., and Kusumoto, K., The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease. Circ Res., 85, 777-786 (1999).
-
(1999)
Circ Res
, vol.85
, pp. 777-786
-
-
Karmazyn, M.1
Gan, X.T.2
Humphreys, R.A.3
Yoshida, H.4
Kusumoto, K.5
-
6
-
-
0035193493
-
Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism
-
Kenworthy, K. E., Clarke, S. E., Andrews, J., and Houston, J. B., Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism. Drug Metab Dispos, 29, 1644-1651 (2001).
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1644-1651
-
-
Kenworthy, K.E.1
Clarke, S.E.2
Andrews, J.3
Houston, J.B.4
-
7
-
-
33644658185
-
In vitro metabolism of a new cardioprotective agent, KR-32570, in human liver microsomes
-
Kim, H., Kang, S., Kim, H., Yoon, Y. J., Cha, E. Y., Lee, H. S., Kim, J. H., Yea, S. S., Lee, S. S., Shin, J. G., and Liu, K. H., In vitro metabolism of a new cardioprotective agent, KR-32570, in human liver microsomes. Rapid. Commun. Mass. Spectrom., 20, 837-843 (2006).
-
(2006)
Rapid. Commun. Mass. Spectrom
, vol.20
, pp. 837-843
-
-
Kim, H.1
Kang, S.2
Kim, H.3
Yoon, Y.J.4
Cha, E.Y.5
Lee, H.S.6
Kim, J.H.7
Yea, S.S.8
Lee, S.S.9
Shin, J.G.10
Liu, K.H.11
-
8
-
-
28044472789
-
-
Kim, M. J., Moon, C. H., Kim, M. Y., Lee, S., Yi, K. Y., Yoo, S. E., Lee, S. H., Baik, E. J., and Jung, Y. S., KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death pathway in H9c2 cells. Eur. J. Pharmacol., 525, 1-7 (2005).
-
Kim, M. J., Moon, C. H., Kim, M. Y., Lee, S., Yi, K. Y., Yoo, S. E., Lee, S. H., Baik, E. J., and Jung, Y. S., KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death pathway in H9c2 cells. Eur. J. Pharmacol., 525, 1-7 (2005).
-
-
-
-
9
-
-
27644572241
-
Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion
-
Lee, B. H., Yi, K. Y., Lee, S., Lee, S., and Yoo, S. E., Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion. Eur. J. Pharmacol., 523, 101-108 (2005a).
-
(2005)
Eur. J. Pharmacol
, vol.523
, pp. 101-108
-
-
Lee, B.H.1
Yi, K.Y.2
Lee, S.3
Lee, S.4
Yoo, S.E.5
-
10
-
-
17544378824
-
(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1
-
Lee, S., Yi, K. Y., Hwang, S. K., Lee, B. H., Yoo, S. E., and Lee, K., (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J. Med. Chem., 48, 2882-2891 (2005b).
-
(2005)
J. Med. Chem
, vol.48
, pp. 2882-2891
-
-
Lee, S.1
Yi, K.Y.2
Hwang, S.K.3
Lee, B.H.4
Yoo, S.E.5
Lee, K.6
-
11
-
-
0035059509
-
Substrate inhibition kinetics for cytochrome P450-catalyzed reactions
-
Lin, Y., Lu, P., Tang, C., Mei, Q., Sandig, G., Rodrigues, A. D., Rushmore, T. H., and Shou, M., Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug. Metab. Dispos., 29, 368-374 (2001).
-
(2001)
Drug. Metab. Dispos
, vol.29
, pp. 368-374
-
-
Lin, Y.1
Lu, P.2
Tang, C.3
Mei, Q.4
Sandig, G.5
Rodrigues, A.D.6
Rushmore, T.H.7
Shou, M.8
-
12
-
-
0033105118
-
Integrated cytochrome P450 reaction phenotyping: Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes
-
Rodrigues, A. D., Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Biochem. Pharmacol., 57, 465-480 (1999).
-
(1999)
Biochem. Pharmacol
, vol.57
, pp. 465-480
-
-
Rodrigues, A.D.1
-
13
-
-
0035699920
-
Triazolam substrate inhibition: Evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site
-
Schrag, M. L. and Wienkers, L. C., Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site. Adv Exp Med Biol., 500, 347-350 (2001).
-
(2001)
Adv Exp Med Biol
, vol.500
, pp. 347-350
-
-
Schrag, M.L.1
Wienkers, L.C.2
-
14
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., and Guengerich, F. P., Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther., 270, 414-423 (1994).
-
(1994)
J. Pharmacol. Exp. Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
15
-
-
0033564235
-
Sigmoidal kinetic model for two cooperative substrate-binding sites in a cytochrome P450 3A4 active site: An example of the metabolism of diazepam and its derivatives
-
Shou, M., Mei, Q., Ettore, M. W., Jr., Dai, R., Baillie, T. A., and Rushmore, T. H., Sigmoidal kinetic model for two cooperative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem. J., 340 ( Pt 3), 845-853 (1999).
-
(1999)
Biochem. J
, vol.340
, Issue.PART 3
, pp. 845-853
-
-
Shou, M.1
Mei, Q.2
Ettore Jr., M.W.3
Dai, R.4
Baillie, T.A.5
Rushmore, T.H.6
-
16
-
-
0031028518
-
Cooperativity in oxidations catalyzed by cytochrome P450 3A4
-
Ueng, Y. F., Kuwabara, T., Chun, Y. J., and Guengerich, F. P., Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry, 36, 370-381 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 370-381
-
-
Ueng, Y.F.1
Kuwabara, T.2
Chun, Y.J.3
Guengerich, F.P.4
-
17
-
-
0031952437
-
Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man
-
Venkatakrishnan, K., von Moltke, L. L., Duan, S. X., Fleishaker, J. C., Shader, R. I., and Greenblatt, D. J., Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J. Pharm. Pharmacol., 50, 265-274 (1998).
-
(1998)
J. Pharm. Pharmacol
, vol.50
, pp. 265-274
-
-
Venkatakrishnan, K.1
von Moltke, L.L.2
Duan, S.X.3
Fleishaker, J.C.4
Shader, R.I.5
Greenblatt, D.J.6
-
18
-
-
0038002981
-
The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
-
Ward, B. A., Gorski, J. C., Jones, D. R., Hall, S. D., Flockhart, D. A., and Desta, Z., The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J. Pharmacol. Exp. Ther., 306, 287-300 (2003).
-
(2003)
J. Pharmacol. Exp. Ther
, vol.306
, pp. 287-300
-
-
Ward, B.A.1
Gorski, J.C.2
Jones, D.R.3
Hall, S.D.4
Flockhart, D.A.5
Desta, Z.6
|