Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration

Biological Psychiatry

Volumn 61, Issue 11, 2007, Pages 1310-1313

  Kalayasiri, Rasmon ^a,d   Sughondhabirom, Atapol ^d   Gueorguieva, Ralitza ^a   Coric, Vladimir ^a   Lynch, Wendy J ^b   Lappalainen, Jaakko ^a   Gelernter, Joel ^a   Cubells, Joseph F ^c   Malison, Robert T ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Cocaine; dependence; dopamine hydroxylase; genetics; paranoia; psychosis; self administration

Indexed keywords

OXYGENASE;

ADULT; AFRICAN AMERICAN; ARTICLE; CLINICAL ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DEMOGRAPHY; DNA POLYMORPHISM; FEMALE; GENE; GENOTYPE; HOMOZYGOTE; HUMAN; MALE; PARANOIA; PHARMACOGENETICS; PRIORITY JOURNAL; SELF REPORT; VISUAL ANALOG SCALE;

ADULT; ALLELES; COCAINE; COCAINE-RELATED DISORDERS; DOPAMINE BETA-HYDROXYLASE; FEMALE; GENOTYPE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PARANOID DISORDERS; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; REINFORCEMENT SCHEDULE;

EID: 34248166002     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.08.012     Document Type: Article

References (24)

1. Angrist B.M. Cocaine in the context of prior central nervous system stimulant epidemics. In: Volkow N.D., and Swan A.C. (Eds). Cocaine in the brain (1990), Rutgers University Press, New Brunswick, NJ
2. Bartlett E., Hallin A., Chapman B., and Angrist B. Selective sensitization to the psychosis-inducing effects of cocaine: A possible marker for addiction relapse vulnerability?. Neuropsychopharmacology 16 (1997) 77-82
3. Brady K.T., Lydiard R.B., Malcolm R., and Ballenger J.C. Cocaine-induced psychosis. J Clin Psychiatry 52 (1991) 509-512
4. Brunner E., Domhof S., and Langer F. Nonparametric analysis of longitudinal data in factorial experiments (2002), Wiley, New York
5. Carroll K.M., Fenton L.R., Ball S.A., Nich C., Frankforter T.L., Shi J., and Rounsaville B.J. Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: A randomized placebo-controlled trial. Arch Gen Psychiatry 61 (2004) 264-272
6. Cubells J.F., Feinn R., Pearson D., Burda J., Tang Y., Farrer L.A., et al. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Drug Alcohol Depend 80 (2005) 23-33
7. Cubells J.F., Kranzler H.R., McCance-Katz E., Anderson G.M., Malison R.T., Price L.H., and Gelernter J. A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia. Mol Psychiatry 5 (2000) 56-63
8. Gelernter J., Kranzler H.R., Satel S.L., and Rao P.A. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology 11 (1994) 195-200
9. Gelernter J., Panhuysen C., Weiss R., Brady K., Hesselbrock V., Rounsaville B., et al. Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine-related trait and cocaine-induced paranoia. Am J Med Genet B Neuropsychiatr Genet 136 (2005) 45-52
10. Healy D.G., Abou-Sleiman P.M., Ozawa T., Lees A.J., Bhatia K., Ahmadi K.R., et al. A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. Ann Neurol 55 (2004) 443-446
11. Kalayasiri R., Kranzler H.R., Weiss R., Brady K., Gueorguieva R., Panhuysen C., et al. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug Alcohol Depend 84 (2006) 77-84
12. Kalayasiri R., Sughondhabirom A., Gueorguieva R., Coric V., Lynch W.J., Morgan P.T., et al. Self-reported paranoia during laboratory "binge" cocaine self-administration in humans. Pharmacol Biochem Behav 83 (2006) 249-256
13. Lynch W.J., Sughondhabirom A., Pittman B., Gueorguieva R., Kalayasiri R., Joshua D., et al. A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: A randomized trial. Psychopharmacology (Berl) 185 (2006) 306-314
14. Mooney M., Sofuoglu M., Dudish-Poulsen S., and Hatsukami D.K. Preliminary observations of paranoia in a human laboratory study of cocaine. Addict Behav 31 (2006) 1245-1251
15. Muntaner C., Kumor K.M., Nagoshi C., and Jaffe J.H. Intravenous cocaine infusions in humans: Dose responsivity and correlations of cardiovascular vs. subjective effects. Pharmacol Biochem Behav 34 (1989) 697-703
16. Pearlson G.D., Fischman M.W., Foltin R.W., Cornell E., and Pedroso J.J. Cocaine-induced delirium versus delusional disorder. Biol Psychiatry 26 (1989) 847-848
17. Petrakis I.L., Carroll K.M., Nich C., Gordon L.T., McCance-Katz E.F., Frankforter T., and Rounsaville B.J. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction 95 (2000) 219-228
18. Rosse R.B., Collins Jr. J.P., Fay-McCarthy M., Alim T.N., Wyatt R.J., and Deutsch S.I. Phenomenologic comparison of the idiopathic psychosis of schizophrenia and drug-induced cocaine and phencyclidine psychoses: A retrospective study. Clin Neuropharmacol 17 (1994) 359-369
19. Satel S.L., Southwick S.M., and Gawin F.H. Clinical features of cocaine-induced paranoia. Am J Psychiatry 148 (1991) 495-498
20. Schank JR, Ventura R, Puglisi-Allegra S, Alcaro A, Cole CD, Liles LC, et al (in press): Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology [Epub ahead of print].
21. Sherer M.A., Kumor K.M., Cone E.J., and Jaffe J.H. Suspiciousness induced by four-hour intravenous infusions of cocaine. Preliminary findings. Arch Gen Psychiatry 45 (1988) 673-677
22. Sughondhabirom A., Jain D., Gueorguieva R., Coric V., Berman R., Lynch W.J., et al. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology (Berl) 180 (2005) 436-446
23. Zabetian C.P., Anderson G.M., Buxbaum S.G., Elston R.C., Ichinose H., Nagatsu T., et al. A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet 68 (2001) 515-522
24. Zabetian C.P., Buxbaum S.G., Elston R.C., Kohnke M.D., Anderson G.M., Gelernter J., and Cubells J.F. The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity. Am J Hum Genet 72 (2003) 1389-1400