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Volumn 21, Issue 5, 2007, Pages 553-566

Optimizing palliative treatment of metastatic colorectal cancer in the era of biologic therapy

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; ERLOTINIB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; UNCLASSIFIED DRUG; VATALANIB; VECTIBIX;

EID: 34248165963     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (18)

References (49)
  • 1
    • 0034712536 scopus 로고    scopus 로고
    • Douillard JY, Cunningham D, Roth AD, et al: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 355:1041-1047, 2000 (erratum in Lancet 355:1372, 2000).
    • Douillard JY, Cunningham D, Roth AD, et al: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 355:1041-1047, 2000 (erratum in Lancet 355:1372, 2000).
  • 2
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, et al: Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 23:3706-3712, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3
  • 3
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938-2947, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 4
    • 0001120708 scopus 로고    scopus 로고
    • Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/ FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC) (abstract 512)
    • Grothey A, Deschler B, Kroening H, et al: Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/ FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC) (abstract 512). Proc Am Soc Clin Oncol 20:129a, 2002.
    • (2002) Proc Am Soc Clin Oncol , vol.20
    • Grothey, A.1    Deschler, B.2    Kroening, H.3
  • 5
    • 17744418861 scopus 로고    scopus 로고
    • Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952
    • Kohne CH, Wils J, Lorenz M, et al: Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952. J Clin Oncol 21:3721-2728, 2003.
    • (2003) J Clin Oncol , vol.21 , pp. 3721-2728
    • Kohne, C.H.1    Wils, J.2    Lorenz, M.3
  • 6
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343:905-914, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 7
    • 34248209537 scopus 로고    scopus 로고
    • Capecitabine plus irinotecan versus 5-FU/FA/irinotecan +/- celecoxib in first line treatment of metastatic colorectal cancer. Safety results of the prospective multicenter EORTC phase III study 40015 (abstract 3525)
    • 252s
    • Kohne C, de Greve J, Bokemeyer C, et al: Capecitabine plus irinotecan versus 5-FU/FA/irinotecan +/- celecoxib in first line treatment of metastatic colorectal cancer. Safety results of the prospective multicenter EORTC phase III study 40015 (abstract 3525). J Clin Oncol 23(16S):252s, 2005.
    • (2005) J Clin Oncol 23(16S)
    • Kohne, C.1    de Greve, J.2    Bokemeyer, C.3
  • 8
    • 0033989203 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • Giacchetti S, Perpoint B, Zidani R, et al: Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18:136-147, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 136-147
    • Giacchetti, S.1    Perpoint, B.2    Zidani, R.3
  • 9
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, et al: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22:23-30, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 10
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E, et al: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 22:229-237, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 11
    • 24644457747 scopus 로고    scopus 로고
    • Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer. A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
    • Colucci G, Gebbia V, Paoletti G, et al: Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer. A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 23:4866-4875, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 4866-4875
    • Colucci, G.1    Gebbia, V.2    Paoletti, G.3
  • 12
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM, et al: Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 22:1209-1214, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 13
    • 33644825856 scopus 로고    scopus 로고
    • Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line
    • Grothey A, Sargent D: Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line. J Clin Oncol 23:9441-9442, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 9441-9442
    • Grothey, A.1    Sargent, D.2
  • 14
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, et al: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study. J Clin Oncol 19:2282-2292, 2001.
    • (2001) J Clin Oncol , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 15
    • 0036235128 scopus 로고    scopus 로고
    • First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    • Cassidy J, Twelves C, Van Cutsem E, et al: First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 13:566-575, 2002.
    • (2002) Ann Oncol , vol.13 , pp. 566-575
    • Cassidy, J.1    Twelves, C.2    Van Cutsem, E.3
  • 16
    • 33745924802 scopus 로고    scopus 로고
    • Randomized trial of infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) versus capecitabine plus oxaliplatin (CAPOX) as first line treatment of metastatic colorectal carcinoma (MCRC): Final results of the safety and efficacy analysis (abstract 277)
    • Presented at the, San Francisco; January 26-28
    • Kubicka S, Arkenau H, Grothey A, et al: Randomized trial of infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) versus capecitabine plus oxaliplatin (CAPOX) as first line treatment of metastatic colorectal carcinoma (MCRC): final results of the safety and efficacy analysis (abstract 277). Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium. San Francisco; January 26-28, 2006.
    • (2006) American Society of Clinical Oncology Gastrointestinal Cancers Symposium
    • Kubicka, S.1    Arkenau, H.2    Grothey, A.3
  • 17
    • 34248147447 scopus 로고    scopus 로고
    • First efficacy and safety results from XELOX-1/NO16966, a randomised 2 x 2 factorial phase III trial of XELOX vs. FOLFOX4 + bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC) (abstract LBA3)
    • Cassidy J, Clarke S, Diaz Rubio E, et al: First efficacy and safety results from XELOX-1/NO16966, a randomised 2 x 2 factorial phase III trial of XELOX vs. FOLFOX4 + bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC) (abstract LBA3). Ann Oncol 17(suppl 9), 2006.
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 9
    • Cassidy, J.1    Clarke, S.2    Diaz Rubio, E.3
  • 18
    • 3042562289 scopus 로고    scopus 로고
    • Phase II trial of capecitabine/irinotecan and capecitabine/oxaliplatin in advanced gastrointestinal cancers
    • Jordan K, Kellner O, Kegel T, et al: Phase II trial of capecitabine/irinotecan and capecitabine/oxaliplatin in advanced gastrointestinal cancers. Clin Colorectal Cancer 4:56-50, 2004.
    • (2004) Clin Colorectal Cancer , vol.4 , pp. 56-50
    • Jordan, K.1    Kellner, O.2    Kegel, T.3
  • 19
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 20
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Hainsworth J, et al: Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer. J Clin Oncol 23:3502-3508, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3502-3508
    • Hurwitz, H.1    Fehrenbacher, L.2    Hainsworth, J.3
  • 21
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Final analysis of the TREE study (abstract 3510)
    • 148s
    • Hochster HS, Hart LL, Ramanathan RK, et al: Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Final analysis of the TREE study (abstract 3510). J Clin Oncol 24(18S):148s, 2006.
    • (2006) J Clin Oncol 24(18S)
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 22
    • 34248224121 scopus 로고    scopus 로고
    • Updated results of BICC-C study comparing first-line irinotecan/fluoropymidine combinations ± celecoxib in mCRC: Clinical data cut-off September 1, 2006 (abstract 276)
    • Presented at the, Orlando, Fla; January 19-21
    • Fuchs CS, Marshall J, Mitchell EP, et al: Updated results of BICC-C study comparing first-line irinotecan/fluoropymidine combinations ± celecoxib in mCRC: Clinical data cut-off September 1, 2006 (abstract 276). Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium. Orlando, Fla; January 19-21, 2007.
    • (2007) American Society of Clinical Oncology Gastrointestinal Cancers Symposium
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.P.3
  • 23
    • 21244481589 scopus 로고    scopus 로고
    • High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200 (abstract 2)
    • 1s
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al: High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200 (abstract 2). J Clin Oncol 23(16S):1s, 2005.
    • (2005) J Clin Oncol 23(16S)
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 24
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 25
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer (abstract 3508)
    • 248s
    • Saltz LB, Lenz H-J, Hochster H, et al: Randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer (abstract 3508). J Clin Oncol 23(16S):248s, 2005.
    • (2005) J Clin Oncol 23(16S)
    • Saltz, L.B.1    Lenz, H.-J.2    Hochster, H.3
  • 26
    • 33749015088 scopus 로고    scopus 로고
    • A phase 3, multicenter, randomized controlled trial (RCT) of panitumumab plus best supportive care (BSC) vs BSC alone in patients (pts) with metastatic colorectal cancer (mCRC) (abstract CP-1)
    • Presented at the Washington, DC; April 1-4
    • Peeters M, Van Cutsem E, Siena S, et al: A phase 3, multicenter, randomized controlled trial (RCT) of panitumumab plus best supportive care (BSC) vs BSC alone in patients (pts) with metastatic colorectal cancer (mCRC) (abstract CP-1). Presented at the 97th Annual Meeting of the American Association for Cancer Research; Washington, DC; April 1-4 2006.
    • (2006) 97th Annual Meeting of the American Association for Cancer Research
    • Peeters, M.1    Van Cutsem, E.2    Siena, S.3
  • 27
    • 34248225777 scopus 로고    scopus 로고
    • Detailed analysis of oxaliplatin-associated neurotoxicity in Intergroup trial N9741 (abstract 264O)
    • Green EM, Sargent DJ, Goldberg RM, et al: Detailed analysis of oxaliplatin-associated neurotoxicity in Intergroup trial N9741 (abstract 264O). Ann Oncol 15(suppl 3):70, 2004.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 3 , pp. 70
    • Green, E.M.1    Sargent, D.J.2    Goldberg, R.M.3
  • 28
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer - a GERCOR study
    • Tournigand C, Cervantes A, Figer A, et al: OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer - a GERCOR study. J Clin Oncol 24:394-400, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3
  • 29
    • 33750163133 scopus 로고    scopus 로고
    • OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC). A GERCOR study (abstract 3504)
    • 147s
    • Maindrault-Goebel F, Lledo G, Chibaudel B, et al: OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC). A GERCOR study (abstract 3504). J Clin Oncol 24(18S):147s, 2006.
    • (2006) J Clin Oncol 24(18S)
    • Maindrault-Goebel, F.1    Lledo, G.2    Chibaudel, B.3
  • 34
    • 34248142823 scopus 로고    scopus 로고
    • National Institutes of Health:, Available at, Updated February 15, 2007. Accessed March 8
    • National Institutes of Health: PACCE: Panitumumab Advanced Colorectal Cancer Evaluation study. Available at www.clinicaltrials.gov. ClinicalTrials.gov identifier: NCT00115765. Updated February 15, 2007. Accessed March 8, 2007.
    • (2007) PACCE: Panitumumab Advanced Colorectal Cancer Evaluation study
  • 35
    • 14644429819 scopus 로고    scopus 로고
    • 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: A North Central Cancer Treatment Group study
    • D' Andre S, Sargent DJ, Cha SS, et al: 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: A North Central Cancer Treatment Group study. Clin Colorectal Cancer 4:325-331, 2005.
    • (2005) Clin Colorectal Cancer , vol.4 , pp. 325-331
    • D' Andre, S.1    Sargent, D.J.2    Cha, S.S.3
  • 36
    • 0022372352 scopus 로고
    • Relationship between age at diagnosis and treatments received by cancer patients
    • Mor V, Masterson-Allen S, Goldberg RJ, et al: Relationship between age at diagnosis and treatments received by cancer patients. J Am Geriatr Soc 33:585-589, 1985.
    • (1985) J Am Geriatr Soc , vol.33 , pp. 585-589
    • Mor, V.1    Masterson-Allen, S.2    Goldberg, R.J.3
  • 37
    • 0023194719 scopus 로고
    • Patterns of care related to age of breast cancer patients
    • Greenfield S, Blanco DM, Elashoff RM, et al: Patterns of care related to age of breast cancer patients. JAMA 257:2766-2770, 1987.
    • (1987) JAMA , vol.257 , pp. 2766-2770
    • Greenfield, S.1    Blanco, D.M.2    Elashoff, R.M.3
  • 38
    • 33847187092 scopus 로고    scopus 로고
    • A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer (abstract 228)
    • Presented at the, San Francisco; January 26-28
    • Goldberg RM, Sargent D, Bleiberg H, et al: A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer (abstract 228). Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium. San Francisco; January 26-28, 2006.
    • (2006) American Society of Clinical Oncology Gastrointestinal Cancers Symposium
    • Goldberg, R.M.1    Sargent, D.2    Bleiberg, H.3
  • 39
    • 9744230871 scopus 로고    scopus 로고
    • OPTIMOX study: FOLFOX 7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer (abstract 3525)
    • de Gramont A, Cervantes A, Andre T, et al: OPTIMOX study: FOLFOX 7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer (abstract 3525). Proc Am Soc Clin Oncol 23:251, 2004
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 251
    • de Gramont, A.1    Cervantes, A.2    Andre, T.3
  • 40
    • 24344453964 scopus 로고    scopus 로고
    • 5-Fluorouracil, folinic acid and oxaliplatin (FOLFOX) in very old patients with metastatic colorectal cancer (abstract 3571)
    • Figer A, Perez N, Carola E, et al: 5-Fluorouracil, folinic acid and oxaliplatin (FOLFOX) in very old patients with metastatic colorectal cancer (abstract 3571). Proc Am Soc Clin Oncol 23:263, 2004.
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 263
    • Figer, A.1    Perez, N.2    Carola, E.3
  • 41
    • 21244505977 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan/5-FU/leucovorin for treatment of metastatic colorectal cancer results in survival benefit in all pre-specified patient subgroups (abstract 3617)
    • Fyfe GA, Hurwitz H, Fehrenbacher L, et al: Bevacizumab plus irinotecan/5-FU/leucovorin for treatment of metastatic colorectal cancer results in survival benefit in all pre-specified patient subgroups (abstract 3617). Proc Am Soc Clin Oncol 23:274, 2004.
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 274
    • Fyfe, G.A.1    Hurwitz, H.2    Fehrenbacher, L.3
  • 42
    • 33847209311 scopus 로고    scopus 로고
    • Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy (abstract 3019)
    • 196s
    • Skillings JR, Johnson DH, Miller K, et al: Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy (abstract 3019). J Clin Oncol 23(16S):196s, 2005.
    • (2005) J Clin Oncol 23(16S)
    • Skillings, J.R.1    Johnson, D.H.2    Miller, K.3
  • 43
    • 9744251552 scopus 로고    scopus 로고
    • Current perspectives in the treatment of metastatic colorectal cancer
    • Kohne CH, Folprecht G: Current perspectives in the treatment of metastatic colorectal cancer. Ann Oncol 15(suppl 4):iv43-53, 2004.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 4
    • Kohne, C.H.1    Folprecht, G.2
  • 44
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al: Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial. J Clin Oncol 23:3697-3705, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 45
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK: Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307:58-62, 2005.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 46
    • 33746571577 scopus 로고    scopus 로고
    • Clinical benefit from bevacizumab (BV) in responding (R) and non-responding (NR) patients (pts) with metastatic colorectal cancer (mCRC)
    • 249s
    • Mass RD, Sarkar S, Holden SN, et al: Clinical benefit from bevacizumab (BV) in responding (R) and non-responding (NR) patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol 23(16 suppl):249s, 2005.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Mass, R.D.1    Sarkar, S.2    Holden, S.N.3
  • 47
    • 34248191170 scopus 로고    scopus 로고
    • Randomized study of sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC), an interim safety analysis: A Dutch Colorectal Cancer Group (DCCG) phase III study (abstract 282)
    • Presented at the Atlanta; June 2-6
    • Grothey A, Sargent D: Randomized study of sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC), an interim safety analysis: A Dutch Colorectal Cancer Group (DCCG) phase III study (abstract 282). Presented at the 42nd Annual Meeting of the American Society of Clinical Oncology; Atlanta; June 2-6, 2006.
    • (2006) 42nd Annual Meeting of the American Society of Clinical Oncology
    • Grothey, A.1    Sargent, D.2
  • 48
    • 34248162859 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network (NCCN): Clinical Practice Guidelines in Oncology. Colon Cancer v.1.2005.
    • National Comprehensive Cancer Network (NCCN): Clinical Practice Guidelines in Oncology. Colon Cancer v.1.2005.
  • 49
    • 23844448040 scopus 로고    scopus 로고
    • Neoadjuvant treatment of unresectable colorectal liver metastases: Correlation between tumour response and resection rates
    • Folprecht G, Grothey A, Alberts S, et al: Neoadjuvant treatment of unresectable colorectal liver metastases: Correlation between tumour response and resection rates. Ann Oncol 16:1311-1319, 2005.
    • (2005) Ann Oncol , vol.16 , pp. 1311-1319
    • Folprecht, G.1    Grothey, A.2    Alberts, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.