Weight Loss in the Nursing Home

Journal of the American Medical Directors Association

Volumn 8, Issue 4, 2007, Pages 201-204

  Morley, John E ^a  

^a S LOUIS UNIV HLTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC AGENT; ANDROGEN; APPETITE STIMULANT; CHOLECYSTOKININ; CYTOKINE ANTIBODY; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; LIPID; MEGESTROL; NANDROLONE; PRASTERONE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TESTOSTERONE; THALIDOMIDE; UNCLASSIFIED DRUG;

AGED; AGING; ANOREXIA; BODY WEIGHT DISORDER; CACHEXIA; CALORIC INTAKE; CLINICAL TRIAL; COMMUNITY CARE; DEHYDRATION; DEPRESSION; DISEASE SEVERITY; DRUG SYNTHESIS; EDITORIAL; FEEDING; FOOD INTAKE; HUMAN; HYPERMETABOLISM; HYPOALBUMINEMIA; MALABSORPTION; MALNUTRITION; META ANALYSIS; MORBIDITY; MORTALITY; MUSCLE ATROPHY; NONHUMAN; NURSING HOME; PARENTERAL NUTRITION; SATIETY; SMELLING DISORDER; STOMACH EMPTYING; SYSTEMATIC REVIEW; TASTE DISORDER; WEIGHT GAIN; WEIGHT REDUCTION; APPETITE; GERIATRIC ASSESSMENT; QUESTIONNAIRE;

AGED; ANOREXIA; APPETITE; CACHEXIA; DEHYDRATION; GERIATRIC ASSESSMENT; HUMANS; MUSCULAR ATROPHY; NURSING HOMES; QUESTIONNAIRES; WEIGHT LOSS;

EID: 34248155806     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2007.02.003     Document Type: Editorial

References (92)

1. Sullivan D.H., Morley J.E., Johnson L.E., et al. The GAIN (Geriatric Anorexia Nutrition) registry: The impact of appetite and weight on mortality in a long-term care population. J Nutr Health Aging 6 (2002) 275-281
2. Amador L.F., Al Snih S., Markides K.S., and Goodwin J.S. Weight change and mortality among older Mexican Americans. Aging Clin Exp Res 18 (2006) 196-204
3. Keller H.H., and Ostbye T. Body Mass Index (BMI), BMI change and mortality in community-dwelling seniors without dementia. J Nutr Health Aging 9 (2005) 316-320
4. Wedick N.M., Barrett-Connor E., Knoke J.D., and Wingard D.L. The relationship between weight loss and all-cause mortality in older men and women with and without diabetes mellitus: The Rancho Bernardo study. J Am Geriatr Soc 50 (2002) 1810-1815
5. Kiely D.K., and Flacker J.M. Resident characteristics associated with mortality in long-term care nursing homes: Is there a gender difference?. J Am Med Dir Assoc 1 (2000) 8-13
6. Wang S.Y., Fukagawa N., Hossain M., and Ooi W.L. Longitudinal weight changes, length of survival, and energy requirements of long-term care residents with dementia. J Am Geriatr Soc 45 (1997) 1189-1195
7. Ryan C., Bryant E., Eleazer P., et al. Unintentional weight loss in long-term care: Predictor of mortality in the elderly. South Med J 88 (1995) 721-724
8. Ensrud K.E., Ewing S.K., Stone K.L., et al., Study of Osteoporotic Fractures Research Group. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc 51 (2003) 1740-1757
9. Langlois J.A., Mussolino M.E., Visser M., et al. Weight loss from maximum body weight among middle-aged and older white women and the risk of hip fracture: The NHANES I epidemiologic follow-up study. Osteoporos Int 12 (2001) 763-768
10. Langlois J.A., Harris T., Looker A.C., and Madans J. Weight change between age 50 years and old age is associated with risk of hip fracture in white women aged 67 years and older. Arch Intern Med 156 (1996) 989-994
11. Bartali B., Frongillo E.A., Bandinelli S., et al. Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci 61 (2006) 589-593
12. Fried L.P., Ferrucci L., Darer J., et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59 (2004) 255-263
13. Fried L.P., Tangen C.M., Walston J., et al., Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (2001) M146-M156
14. Morley J.E., Kim M.J., Haren M.T., et al. Frailty and the aging male. Aging Male 8 (2005) 135-140
15. Morley J.E., Perry III H.M., and Miller D.K. Something about frailty. J Gerontol A Biol Sci Med Sci 57 (2002) M698-M704
16. Avenell A., and Handoll H.H. Nutritional supplementation for hip fracture aftercare in older people. Cochrane Database Syst Rev 4 (2006) CD001880.
17. Milne A.C., Potter J., and Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2 (2005) CD003288.
18. Morley J.E. Anorexia and weight loss in older persons. J Gerontol A Biol Sci Med Sci 58 (2003) 131-137
19. Morley J.E., Thomas, and Wilson M.M. Cachexia: Pathophysiology and clinical relevance. Dr. Am J Clin Nutr 83 (2006) 735-743
20. Morley J.E. Anorexia, sarcopenia, and aging. Nutrition 17 (2001) 660-663
21. Morley J.E., Baumgartner R.N., Roubenoff R., et al. Sarcopenia. J Lab Clin Med 137 (2001) 231-243
22. Wilson M.M., and Morley J.E. Impaired cognitive function and mental performance in mild dehydration. Eur J Clin Nutr 57 Suppl 2 (2003) S24-S29
23. Aoyoma L., Weintraub N., and Reuben D.B. Is weight loss in the nursing home a reversible problem?. J Am Med Dir Assoc 7 3 Suppl (2006) S66-S72
24. Morley J.E., and Silver A.J. Nutritional issues in nursing home care. Ann Intern Med 123 (1995) 850-859
25. Rolland Y., Kim M.J., Gammack J.K., et al. Office management of weight loss in older persons. Am J Med 1 (2006) 1019-1026
26. Morley J.E., and Kraenzle D. Causes of weight loss in a community nursing home. J Am Geriatr Soc 42 (1994) 583-585
27. Wilson M.M., Thomas D.R., Rubenstein L.Z., et al. Appetite assessment: Simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82 (2005) 1074-1081
28. Blazer D.G. Depression in late life: Review and commentary. J Gerontol A Biol Sci Med Sci 58 (2003) 249-265
29. Miller D.K., Malmstrom T.K., Joshi S., et al. Clinically relevant levels of depressive symptoms in community-dwelling middle-aged African Americans. J Am Geriatr Soc 52 (2004) 741-748
30. Morley J.E., and Silver A.J. Anorexia in the elderly. Neurobiol Aging 9 (1988) 9-16
31. MacIntosh C., Morley J.E., and Chapman I.M. The anorexia of aging. Nutrition 16 (2000) 983-995
32. Morley J.E., and Thomas D.R. Anorexia and aging: Pathophysiology. Nutrition 15 (1999) 499-503
33. Morley J.E. Anorexia of aging: Physiologic and pathologic. Am J Clin Nutr 66 (1997) 760-773
34. Clarkston W.K., Pantano M.M., Morley J.E., et al. Evidence for the anorexia of aging: Gastrointestinal transit and hunger in healthy elderly vs young adults. Am J Physiol 272 (1997) R243-R248 1 Pt 2
35. MacIntosh C.G., Morley J.E., Wishart J., et al. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: Evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 86 (2001) 5830-5837
36. Altus D.E., Engelman K.K., and Mathews R.M. Using family-style meals to increase participation and communication in persons with dementia. J Gerontol Nurs 28 (2002) 47-53
37. Remsburg R.E., Luking A., Bara P., et al. Impact of a buffet-style dining program on weight and biochemical indicators of nutritional status in nursing home residents: A pilot study. J Am Diet Assoc 101 (2001) 1460-1463
38. Odlund Olin A., Armyr I., Soop M., et al. Energy-dense meals improve energy intake in elderly residents in a nursing home. Clin Nutr 22 (2003) 125-131
39. Mathey M.F., Vanneste V.G., de Graaf C., et al. Health effect of improved meal ambiance in a Dutch nursing home: A 1-year intervention study. Prev Med 32 (2001) 416-423
40. Nijs K.A., de Graaf C., Siebelink E., et al. Effect of family-style meals on energy intake and risk of malnutrition in Dutch nursing home residents: A randomized controlled trial. J Gerontol A Biol Sci Med Sci 61 (2006) 935-942
41. Nijs K.A., de Graaf C., Kok F.J., and van Staveren W.A. Effect of family style mealtimes on quality of life, physical performance, and body weight of nursing home residents: Cluster randomized controlled trial. BMJ 332 (2006) 1180-1184
42. Simmons S.F., and Levy-Storms L. The effect of dining location on nutritional care quality in nursing homes. J Nutr Health Aging 9 (2005) 434-439
43. Keller H.H., Gibbs-Ward A., Randall-Simpson J., et al. Meal rounds: An essential aspect of quality nutrition services in long-term care. J Am Med Dir Assoc 7 (2006) 40-45
44. Wilson M.M., Purushothaman R., and Morley J.E. Effect of liquid dietary supplements on energy intake in the elderly. Am J Clin Nutr 75 (2002) 944-947
45. Karcic E., Philpot C., and Morley J.E. Treating malnutrition with megestrol acetate: Literature review and review of our experience. J Nutr Health Aging 6 (2002) 191-200
46. Raney M.S., Anding R., Fay V., and Polk G. A pilot study to assess the use of megesterol acetate to promote weight gain in frail elderly persons residing in long-term care. J Am Med Dir Assoc 1 (2000) 154-158
47. Simmons S.F., Walker K.A., and Osterweil D. The effect of megestrol acetate on oral food and fluid intake in nursing home residents: a pilot study. J Am Med Dir Assoc 6 3 Suppl (2005) S5-S11
48. Berenstein E.G., and Ortiz Z. Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev 2 (2005) CD004310.
49. Morley J.E. Anorexia in older persons: Epidemiology and optimal treatment. Drugs Aging 8 (1996) 134-155
50. Jatoi A., Windschitl H.E., Loprinzi C.l., et al. Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: A North Central Cancer Treatment Group Study. J Clin Oncol 20 (2002) 567-573
51. Thomas D.R., Zdrodowski C.D., Wilson M.M., et al. A prospective, randomized clinical study of adjunctive peripheral parenteral nutrition in adult subacute care patients. J Nutr Health Aging 9 (2005) 321-325
52. Omran M.L., and Morley J.E. Assessment of protein energy malnutrition in older persons, Part II: Laboratory evaluation. Nutrition 16 (2000) 131-140
53. Argiles J.M. Cancer-associated malnutrition. Eur J Oncol Nurs 9 Suppl 2 (2005) S39-S50
54. Fearon K.C., Barber M.D., Moses A.G., et al. Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol 24 (2006) 3401-3407
55. Yeh S.S., and Schuster M.W. Geriatric cachexia: The role of cytokines. Am J Clin Nutr 70 (1999) 183-197
56. Morley J.E. Anorexia, sarcopenia, and aging. Nutrition 17 (2001) 660-663
57. Morley J.E., Baumgartner R.N., Roubenoff R., et al. Sarcopenia. J Lab Clin Med 137 (2001) 231-243
58. Janssen I., Heymsfield S.B., and Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50 (2002) 889-896
59. Baumgartner R.N., Wayne S.J., Waters D.L., et al. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res 12 (2004) 1995-2004
60. van den Beld A.W., de Jong F.H., Grobbee D.E., et al. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85 (2000) 3276-3282
61. Baumgartner R.N., Waters D.L., Gallagher D., et al. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 107 (1999) 123-136
62. Roubenoff R. Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging 4 (2000) 140-142
63. Morley J.E., and Baumgartner R.N. Cytokine-related aging process. J Gerontol A Biol Sci Med Sci 59 (2004) M924-M929
64. Singh M.A. Exercise comes of age: Rationale and recommendations for a geriatric exercise prescription. J Gerontol A Biol Sci Med Sci 57 (2002) M262-M282
65. Nieschlag E., Swerdloff R., Behre H.M., et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male 8 (2005) 56-58
66. Sih R., Morley J.E., Kaiser F.E., et al. Testosterone replacement in older hypogonadal men: A 12-month randomized controlled trial. J Clin Endocrinol Metab 82 (1997) 1661-1667
67. Wittert G.A., Chapman I.M., Haren M.T., et al. Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci 58 (2003) 618-625
68. Matsumoto A.M. Andropause: Clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci 57 (2002) M76-M99
69. Asthana S., Bhasin S., Butler R.N., et al. Masculine vitality: Pros and cons of testosterone in treating the andropause. J Gerontol A Biol Sci Med Sci 59A (2004) 461-465
70. Page S.T., Amory J.K., Bowman F.D., et al. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90 (2005) 1502-1510
71. Percheron G., Hogrel J.Y., Denot-Ledunois S., et al. Double-blind placebo-controlled trial. Effect of a 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: A double-blind placebo-controlled trial. Arch Intern Med 163 (2003) 720-727
72. Baulieu E.E., Thomas G., Legrain S., et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A 97 (2000) 4279-4284
73. Nair K.S., Rizza R.A., O'Brien P., et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 355 (2006) 1647-1659
74. Morley J.E., and Perry III H.M. Androgens and women at the menopause and beyond. J Gerontol A Biol Sci Med Sci 58 (2003) M409-M416
75. Frisoli Jr. A., Chaves P.H., Pinheiro M.M., and Szejnfeld V.L. The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: A double-blind, randomized, placebo-controlled clinical trial. J Gerontol A Biol Sci Med Sci 60 (2005) 648-653
76. Gaskin F.S., Farr S.A., Banks W.A., et al. Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24 (2003) 913-918
77. Diano S., Farr S.A., Benoit S.C., et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9 (2006) 381-388
78. Nagaya N., Uematsu M., Kojima M., et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104 (2001) 1430-1435
79. Druce M.R., Neary N.M., Small C.J., et al. Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. Int J Obes 30 (2006) 293-296
80. Kaldy J. Clinical issues in weight loss and dehydration. J Am Med Dir Assoc 1 6 Suppl (2000) S35-S36
81. Smith P.A. Nutrition, hydration, and dysphagia in long-term care: Differing opinions on the effects of aspiration. J Am Med Dir Assoc 7 (2006) 545-549
82. Feinsod F.M., Levenson S.A., Rapp K., et al. Dehydration in frail, older residents in long-term care facilities. J Am Med Dir Assoc 5 2 Suppl (2004) S35-S41
83. Silver A.J., and Morley J.E. Role of the opioid system in the hypodipsia associated with aging. J Am Geriatr Soc 40 (1992) 556-560
84. Finucane T.E., Christmas C., Leff B.A., et al. Tube feeding in dementia: How incentives undermine health care quality and patient safety. J Am Med Dir Assoc 8 4 (2007) 205-208
85. Simmons S.F., and Schnelle J.F. Feeding assistance needs of long-stay nursing home residents and staff time to provide care. J Am Geriatr Soc 54 (2006) 919-924
86. Simmons S.F. Continuous quality improvement for nutritional care services in nursing homes: The importance of direct observation. J Am Med Dir Assoc 7 (2006) 61-62
87. Sasaki H., Sekizawa K., Yanai M., et al. New strategies for aspiration pneumonia. Intern Med 36 (1997) 851-855
88. Thomas D.R., Ashmen W., Morley J.E., and Evans W.J. Nutritional management in long-term care: Development of a clinical guideline. Council for Nutritional Strategies in Long-Term Care. J Gerontol A Biol Sci Med Sci 55 (2000) M725-M734
89. Naito T., Suda T., Yasuda K., et al. A validation and potential modification of the pneumonia severity index in elderly patients with community-acquired pneumonia. J Am Geriatr Soc 54 (2006) 1212-1219
90. Cornali C., Franzoni S., Frisoni G.B., and Trabucchi M. Anorexia as an independent predictor of mortality. J Am Geriatr Soc 53 (2005) 354-355
91. Wilson M.M., Thomas D.R., Rubenstein L.Z., et al. Appetite assessment: Simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82 (2005) 1074-1081
92. Vellas B., Villars H., Abellan G., et al. Overview of the MNA(R)-its history and challenges. J Nutr Health Aging 10 (2006) 456-465