Management of severe acute pain in emergency settings: ketamine reduces morphine consumption

American Journal of Emergency Medicine

Volumn 25, Issue 4, 2007, Pages 385-390

  Galinski, Michel ^a   Dolveck, François ^b   Combes, Xavier ^e   Limoges, Véronique ^c   Smaïl, Nadia ^d   Pommier, Véronique ^c   Templier, François ^b   Catineau, Jean ^a   Lapostolle, Frédéric ^a   Adnet, Frédéric ^a  

^a AVICENNE HOSPITAL   (France)

^b RAYMOND POINCARÉ HOSPITAL   (France)

^c Emergency Department Smur 77   (France)

^d CHU PURPAN   (France)

^e HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; MORPHINE; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG USE; EMERGENCY TREATMENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; VISUAL ANALOG SCALE;

ACUTE DISEASE; ADULT; ANALGESICS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; EMERGENCY MEDICINE; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; KETAMINE; MALE; MORPHINE; PAIN; PAIN MEASUREMENT; PATIENT SATISFACTION; PREANESTHETIC MEDICATION; PROSPECTIVE STUDIES; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 34248149302     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2006.11.016     Document Type: Article

References (28)

1. Belpomme V., Ricard-Hibon A., Cholet C., et al. Délai d'obtention de l'analgésie en préhospitalier. Ann Fr Anesth Reanim 21 (2002) 324S [abstract]
2. Paqueron X., Lumbroso A., Mergoni P., et al. Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration?. Br J Anaesth 89 (2002) 697-701
3. Kehlet H., and Dahl J.B. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth-Analg 77 (1993) 1048-1056
4. Richebé P., Rivat C., Rivalan B., Maurette P., and Simonnet G. Low doses ketamine: antihyperalgesic drug, non-analgesic. Ann Fr Anesth Reanim 24 (2005) 11349-11359
5. Kapfer B., Alfonsi P., Guignard B., Sessler D.I., and Chauvin M. Nefopam and ketamine comparably enhance postoperative analgesia. Anesth Analg 100 (2005) 169-174
6. Suzuki M., Kentaro T., Lansing P.S., Tolan M.M., Fuhrman T.M., Ignacio C.I., et al. Small-dose ketamine enhances morphine-induced analgesia after outpatient surgery. Anesth Analg 89 (1999) 98-103
7. Alvarez P., Saavedra G., Hernandez A., et al. Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat. Anesthesiology 99 (2003) 969-975
8. Bossard A.E., Guirimand F., Fletcher D., et al. Interaction of a combination of morphine and ketamine on the nociceptive flexion reflex in human volunteers. Pain 98 (2002) 47-57
9. Sethna N.F., Liu M., Gracely R., et al. Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. Anesth Analg 86 (1998) 1250-1256
10. Kissin I., Bright C.A., and Bradley Jr. E.L. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?. Anesth Analg 91 (2000) 1483-1488
11. Angst M.S., Koppert W., Pahl I., et al. Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain 106 (2003) 49-57
12. Weinbroum A.A. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain. Anesth Analg 96 (2003) 789-795
13. Bijur P.E., Kenny M.K., and Gallagher E.J. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med 46 (2005) 362-365
14. Mao J., Price D.D., and Mayer D.J. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interaction. Pain 62 (1995) 259-274
15. Adnet F., Jouriles N.J., Le Toumelin P., Hennequin B., Taillandier C., Rayeh F., et al. Survey of out-of-hospital emergency intubations in the French prehospital medical system: a multicenter study. Ann Emerg Med 32 (1998) 454-460
16. Ramsay M.A., Savege T.M., Simpson B.R., and Gooodwin R. Controlled sedation with alphaxalone-alphadolone. Br J Med 2 (1974) 256-259
17. Ricard-Hibon A., Chollet C., Saada S., et al. A quality control program for acute pain management in out-of-hospital critical care medicine. Ann Emerg Med 34 (1999) 738-744
18. Todd K.H., Funk K.G., Funk J.P., and Bonacci R. Clinical significance of reported changes in pain severity. Ann Emerg Med 27 (1996) 485-489
19. Casagrande J.T., Pike M.C., and Smith P.G. An improved approximate formula for calculating sample sizes for comparing two binomial distributions. Biometrics 34 (1978) 483-486
20. Gurnani A., Sharma P.K., Rautela R.S., and Bhattacharya A. Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. Anaesth Intensive Care 24 (1996) 32-36
21. Dickenson A.H. NMDA receptor antagonists: interactions with opioids. Acta Anaesthesiol Scand 41 (1997) 112-115
22. Wiesenfeld-Hallin Z. Combined opioid-NMDA antagonist therapies. What advantages do they offer the control of pain syndromes?. Drugs 56 (1998) 1-5
23. Yaksh T.L. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 41 (1997) 94-111
24. Chapman V., and Dickenson A.H. The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 573 (1992) 321-323
25. Oye I., Paulsen O., and Maurset A. Effects of ketamine on sensory perception: evidence for a role of N-methyl-d-aspartate receptors. J Pharmacol Exp Ther 260 (1992) 1209-1213
26. Krystal J.H., Karper L.P., Seibyl J.P., et al. Subanesthetic effects of noncompetitive NMDA antagonist, ketamine, in humans: psychomimetic, perceptual, cognitive and neuroendocrine responses. Arch Gen Psychiatry 14 (1994) 144-153
27. Bell R.F., Dahl J.B., Moore R.A., and Kalso E. Perioperative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand 49 (2005) 1405-1428
28. Pfenninger E.G., Durieux M.E., and Himmelseher S. Cognitive impairment after small-dose ketamine isomer in comparison to equianalgesic racemic ketamine in human volunteers. Anesthesiology 96 (2002) 357-366