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Volumn 29, Issue 6, 2007, Pages 724-727

NLCQ-1 and NLCQ-2, two new agents with activity against dormant Mycobacterium tuberculosis

Author keywords

Dormancy; Mycobacterium tuberculosis; Nitroimidazole prodrugs; NLCQ 1; NLCQ 2

Indexed keywords

4 [3 (2 NITRO 1 IMIDAZOLYL)PROPYLAMINO] 7 CHLOROQUINOLINE; 4 [4 (2 NITRO 1 IMIDAZOLYL)BUTYLAMINO] 7 CHLOROQUINOLINE; ANTINEOPLASTIC AGENT; CAPREOMYCIN; CLARITHROMYCIN; DNA; ISONIAZID; MINOCYCLINE; NITROIMIDAZOLE; PRODRUG; RIFAMPICIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

EID: 34248144307     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.01.015     Document Type: Article
Times cited : (17)

References (19)
  • 1
    • 0028603583 scopus 로고
    • Dormancy of Mycobacterium tuberculosis and latency of disease
    • Wayne L.G. Dormancy of Mycobacterium tuberculosis and latency of disease. Eur J Clin Microbiol Infect Dis 13 (1994) 908-914
    • (1994) Eur J Clin Microbiol Infect Dis , vol.13 , pp. 908-914
    • Wayne, L.G.1
  • 2
    • 0029976980 scopus 로고    scopus 로고
    • An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
    • Wayne L.G., and Hayes L.G. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64 (1996) 2062-2069
    • (1996) Infect Immun , vol.64 , pp. 2062-2069
    • Wayne, L.G.1    Hayes, L.G.2
  • 3
    • 0035182257 scopus 로고    scopus 로고
    • Dormant tubercle bacilli: the key to more effective TB chemotherapy?
    • Dick T. Dormant tubercle bacilli: the key to more effective TB chemotherapy?. J Antimicrob Chemother 47 (2001) 117-118
    • (2001) J Antimicrob Chemother , vol.47 , pp. 117-118
    • Dick, T.1
  • 4
    • 0032780258 scopus 로고    scopus 로고
    • Why metronidazole is active against both bacteria and parasites
    • Samuelson J. Why metronidazole is active against both bacteria and parasites. Antimicrob Agents Chemother 43 (1999) 1533-1541
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1533-1541
    • Samuelson, J.1
  • 5
    • 0034531320 scopus 로고    scopus 로고
    • Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
    • Murugasu-Oei B., and Dick T. Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG. J Antimicrob Chemother 46 (2000) 917-919
    • (2000) J Antimicrob Chemother , vol.46 , pp. 917-919
    • Murugasu-Oei, B.1    Dick, T.2
  • 6
    • 0032930277 scopus 로고    scopus 로고
    • Metronidazole therapy in mice infected with tuberculosis
    • Brooks J.V., Furney S.K., and Orme I.M. Metronidazole therapy in mice infected with tuberculosis. Antimicrob Agents Chemother 43 (1999) 1285-1288
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1285-1288
    • Brooks, J.V.1    Furney, S.K.2    Orme, I.M.3
  • 7
    • 0034702247 scopus 로고    scopus 로고
    • A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
    • Stover C.K., Warrener P., Vandevanter D.R., et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 405 (2000) 962-966
    • (2000) Nature , vol.405 , pp. 962-966
    • Stover, C.K.1    Warrener, P.2    Vandevanter, D.R.3
  • 8
    • 19544364888 scopus 로고    scopus 로고
    • Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
    • Lenaerts A.J., Gruppo V., Marietta K.S., et al. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother 49 (2005) 2294-2301
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2294-2301
    • Lenaerts, A.J.1    Gruppo, V.2    Marietta, K.S.3
  • 9
    • 31044452898 scopus 로고    scopus 로고
    • Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
    • Manjunatha U.H., Boshoff H., Dowd C.S., et al. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103 (2006) 431-436
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 431-436
    • Manjunatha, U.H.1    Boshoff, H.2    Dowd, C.S.3
  • 10
    • 0034577002 scopus 로고    scopus 로고
    • 4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin
    • Papadopoulou M.V., Ji M., Rao M.K., and Bloomer W.D. 4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin. Oncol Res 12 (2000) 185-192
    • (2000) Oncol Res , vol.12 , pp. 185-192
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 11
    • 0345356572 scopus 로고    scopus 로고
    • Reductive metabolism of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257)
    • Papadopoulou M.V., Ji M., Rao M.K., and Bloomer W.D. Reductive metabolism of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257). Oncol Res 14 (2003) 21-29
    • (2003) Oncol Res , vol.14 , pp. 21-29
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 12
    • 0030903133 scopus 로고    scopus 로고
    • Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
    • Collins L., and Franzblau S.G. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob Agents Chemother 41 (1997) 1004-1009
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1004-1009
    • Collins, L.1    Franzblau, S.G.2
  • 13
    • 33746280567 scopus 로고    scopus 로고
    • Design, synthesis and SAR studies of mefloquine-based ligands as potential antituberculosis agents
    • Jayaprakash S., Iso Y., Wan B., Franzblau S.G., and Kozikowski A.P. Design, synthesis and SAR studies of mefloquine-based ligands as potential antituberculosis agents. Chem Med Chem 1 (2006) 593-597
    • (2006) Chem Med Chem , vol.1 , pp. 593-597
    • Jayaprakash, S.1    Iso, Y.2    Wan, B.3    Franzblau, S.G.4    Kozikowski, A.P.5
  • 14
    • 6344292451 scopus 로고    scopus 로고
    • Exploiting hypoxia in solid tumors with DNA-targeted bioreductive drugs
    • Papadopoulou M.V., and Bloomer W.D. Exploiting hypoxia in solid tumors with DNA-targeted bioreductive drugs. Drugs Future 29 (2004) 807-819
    • (2004) Drugs Future , vol.29 , pp. 807-819
    • Papadopoulou, M.V.1    Bloomer, W.D.2
  • 15
    • 0344629821 scopus 로고    scopus 로고
    • NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug
    • Papadopoulou M.V., and Bloomer W.D. NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug. Clin Cancer Res 9 (2003) 5714-5720
    • (2003) Clin Cancer Res , vol.9 , pp. 5714-5720
    • Papadopoulou, M.V.1    Bloomer, W.D.2
  • 16
    • 0025129860 scopus 로고
    • Evidence for the nature of the link between the arabinogalactan and peptidoglycan components of mycobacterial cell walls
    • McNeil M., Daffe M., and Brennan P.J. Evidence for the nature of the link between the arabinogalactan and peptidoglycan components of mycobacterial cell walls. J Biol Chem 265 (1990) 18200-18206
    • (1990) J Biol Chem , vol.265 , pp. 18200-18206
    • McNeil, M.1    Daffe, M.2    Brennan, P.J.3
  • 17
    • 0035038011 scopus 로고    scopus 로고
    • Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose
    • Ma Y., Stern R.J., Scherman M.S., et al. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45 (2001) 1407-1416
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1407-1416
    • Ma, Y.1    Stern, R.J.2    Scherman, M.S.3
  • 18
    • 0037713601 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of the DNA-binding bioreductive agent NLCQ-1 (NSC 709257) in CD2F1 mice
    • Reid J.M., Squillace D.P., and Ames M.M. Single-dose pharmacokinetics of the DNA-binding bioreductive agent NLCQ-1 (NSC 709257) in CD2F1 mice. Cancer Chemother Pharmacol 51 (2003) 483-487
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 483-487
    • Reid, J.M.1    Squillace, D.P.2    Ames, M.M.3
  • 19
    • 0034012134 scopus 로고    scopus 로고
    • Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice
    • Weber I., Fritz C., Ruttkowski S., Kreft A., and Bange F.C. Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Mol Microbiol 35 (2000) 1017-1025
    • (2000) Mol Microbiol , vol.35 , pp. 1017-1025
    • Weber, I.1    Fritz, C.2    Ruttkowski, S.3    Kreft, A.4    Bange, F.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.